| Role of IL-5 in asthma and airway remodelling. | Role of IL-5 in asthma and airway remodelling.
AbuJabal R, Ramakrishnan RK, Bajbouj K, Hamid Q. | 08/16/2024 |
| Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice. | Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice.
Shen C, Wu N, Chen X, Peng J, Feng M, Wang J, Yu Y., Free PMC Article | 07/29/2024 |
| Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils. | Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Zhang Y, Liu T, Deng Z, Fang W, Zhang X, Zhang S, Wang M, Luo S, Meng Z, Liu J, Sukhova GK, Li D, McKenzie ANJ, Libby P, Shi GP, Guo J., Free PMC Article | 03/8/2023 |
| IL-5-producing CD4[+] T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer. | IL-5-producing CD4(+) T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer.
Blomberg OS, Spagnuolo L, Garner H, Voorwerk L, Isaeva OI, van Dyk E, Bakker N, Chalabi M, Klaver C, Duijst M, Kersten K, Brüggemann M, Pastoors D, Hau CS, Vrijland K, Raeven EAM, Kaldenbach D, Kos K, Afonina IS, Kaptein P, Hoes L, Theelen WSME, Baas P, Voest EE, Beyaert R, Thommen DS, Wessels LFA, de Visser KE, Kok M. | 01/21/2023 |
| Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction. | Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction.
Xu JY, Xiong YY, Tang RJ, Jiang WY, Ning Y, Gong ZT, Huang PS, Chen GH, Xu J, Wu CX, Hu MJ, Xu J, Xu Y, Huang CR, Jin C, Lu XT, Qian HY, Li XD, Yang YJ. | 08/6/2022 |
| IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps. | IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps.
Chen P, Bao C, Zhu R, Wang J, Zhu J, Li Z, Li F, Gu J, Feng X, Li N, Lei L. | 05/28/2022 |
| Deletion of Arno Reduces Eosinophilic Inflammation and Interleukin-5 Expression in a Murine Model of Rhinitis. | Deletion of Arno Reduces Eosinophilic Inflammation and Interleukin-5 Expression in a Murine Model of Rhinitis.
London NR Jr, Tharakan A, Smith A, Thomas KR, Zhu W, Odelberg SJ, Ramanathan M Jr, Lane AP. | 03/26/2022 |
| Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil. | Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil.
Coden ME, Walker MT, Jeong BM, Connelly AR, Nagasaka R, Berdnikovs S., Free PMC Article | 10/23/2021 |
| Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration. | Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration.
Shen ZJ, Hu J, O'Neal MA, Malter JS., Free PMC Article | 10/16/2021 |
| Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. | Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells.
Gitto SB, Beardsley JM, Nakkina SP, Oyer JL, Cline KA, Litherland SA, Copik AJ, Khaled AS, Fanaian N, Arnoletti JP, Altomare DA., Free PMC Article | 08/14/2021 |
| Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA. | Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, Kuroda E, Di Santo JP, Mimuro H, Moro K, Ohno H. | 11/21/2020 |
| Tumour necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis. | Tumour necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis.
Kim DK, Choi SA, Eun KM, Kim SK, Kim DW, Phi JH. | 08/22/2020 |
| Frontline Science: Cytokine-mediated developmental phenotype of mouse eosinophils: IL-5-associated expression of the Ly6G/Gr1 surface Ag. | Frontline Science: Cytokine-mediated developmental phenotype of mouse eosinophils: IL-5-associated expression of the Ly6G/Gr1 surface Ag.
Limkar AR, Mai E, Sek AC, Percopo CM, Rosenberg HF., Free PMC Article | 08/15/2020 |
| IL-38 may enhance airway eosinophilic inflammation in asthma through IL-5 induction | Attenuated Airway Eosinophilic Inflammations in IL-38 Knockout Mouse Model.
Matsuoka M, Kawayama T, Tominaga M, Kaieda S, Tokunaga Y, Kaku Y, Imaoka H, Kinoshita T, Okamoto M, Akiba J, Hoshino T. | 12/14/2019 |
| These data indicate that mice deficient for IL-4R(-/-)/IL-5(-/-) have the highest susceptibility for Litomosoides sigmodontis infection. | Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.
Frohberger SJ, Ajendra J, Surendar J, Stamminger W, Ehrens A, Buerfent BC, Gentil K, Hoerauf A, Hübner MP., Free PMC Article | 07/20/2019 |
| we have studied the gene expression changes associated with IL-5 up-regulation in eosinophils | Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice.
Fairfax KA, Bolden JE, Robinson AJ, Lucas EC, Baldwin TM, Ramsay KA, Cole R, Hilton DJ, de Graaf CA., Free PMC Article | 05/11/2019 |
| binding of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HSP70-1 via the eNOS signaling pathway. | HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway.
Park SL, Chung TW, Kim S, Hwang B, Kim JM, Lee HM, Cha HJ, Seo Y, Choe SY, Ha KT, Kim G, Yun SJ, Park SS, Choi YH, Kim BK, Kim WT, Cha EJ, Patterson C, Kim WJ, Moon SK., Free PMC Article | 11/17/2018 |
| Both pre- and post-transcriptional processes may be involved in the AR modulation of ILC2 IL-5 and IL-13 production. | Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.
Csóka B, Németh ZH, Duerr CU, Fritz JH, Pacher P, Haskó G., Free PMC Article | 10/27/2018 |
| IL-33 acts directly on bone marrow ILC2s, making them an early source of IL-5 and part of a process that is central in IL-33-driven eosinophilia. | Bone marrow type 2 innate lymphoid cells: a local source of interleukin-5 in interleukin-33-driven eosinophilia.
Johansson K, Malmhäll C, Ramos-Ramírez P, Rådinger M., Free PMC Article | 08/18/2018 |
| Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 and GM-CSF. | Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Quail DF, Olson OC, Bhardwaj P, Walsh LA, Akkari L, Quick ML, Chen IC, Wendel N, Ben-Chetrit N, Walker J, Holt PR, Dannenberg AJ, Joyce JA., Free PMC Article | 09/23/2017 |
| these studies establish a basal defect in eosinophilopoiesis in IL-33- and ST2-deficient mice and a mechanism whereby IL-33 supports eosinophils by driving both systemic IL-5 production and the expansion of IL-5Ralpha-expressing precursor cells | IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis.
Johnston LK, Hsu CL, Krier-Burris RA, Chhiba KD, Chien KB, McKenzie A, Berdnikovs S, Bryce PJ., Free PMC Article | 08/19/2017 |
| Increased production of IL-5 from Peyer's patch cells and the restored Th1-type immune response might cause the production of abnormal IgA and might induce the glomerular deposition of IgA in IGA nephropathy. | Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.
Yamanaka T, Tamauchi H, Suzuki Y, Suzuki H, Horikoshi S, Terashima M, Iwabuchi K, Habu S, Okumura K, Tomino Y. | 10/29/2016 |
| E. granulosus infection remarkably reduces the severity of OVA-induced airway inflammation likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A. | Echinococcus granulosus infection reduces airway inflammation of mice likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A.
Wang H, Li J, Pu H, Hasan B, Ma J, Jones MK, Zheng K, Zhang X, Ma H, McManus DP, Lin R, Wen H, Zhang W., Free PMC Article | 11/28/2015 |
| selective proliferation of IgM rheumatoid factor-secreting B-1a cells is induced by co-stimulation by the specific pathogen antigen and IL-5 in the development of MC in Capillaria hepatica-infected mice | The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation.
Aihara N, Kamiie J, Yamada M, Shirota K. | 09/26/2015 |
| IL5, a cytokine involved in allergic and infectious diseases, facilitates metastatic colonization through recruitment of sentinel eosinophils and regulation of other inflammatory/immune cells in the microenvironment of the distal lung. | Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.
Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS Jr, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS., Free PMC Article | 08/15/2015 |