| IL-6/gp130 signaling in CD4[+] T cells drives the pathogenesis of pulmonary hypertension. | IL-6/gp130 signaling in CD4(+) T cells drives the pathogenesis of pulmonary hypertension.
Ishibashi T, Inagaki T, Okazawa M, Yamagishi A, Ohta-Ogo K, Asano R, Masaki T, Kotani Y, Ding X, Chikaishi-Kirino T, Maedera N, Shirai M, Hatakeyama K, Kubota Y, Kishimoto T, Nakaoka Y., Free PMC Article | 04/30/2024 |
| Gp130-HIF1alpha axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling. | Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.
Kang S, Onishi S, Ling Z, Inoue H, Zhang Y, Chang H, Zhao H, Wang T, Okuzaki D, Matsuura H, Takamatsu H, Oda J, Kishimoto T., Free PMC Article | 01/4/2024 |
| Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation. | Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation.
Heinig LC, Huth EVM, Yan K, Schumacher N, Nawrocki M, Lory NC, Bradtke P, Bertram T, Rattay G, Schmid J, Huber S, Wiech T, Schmidt-Arras D, Rose-John S, Mittrücker HW. | 05/17/2023 |
| Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging. | Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Rafii P, Reusswig F, Werner J, Xu H, Lang PA, Rose-John S, Gorressen S, Alter C, Schrader J, Herebian D, Floss DM, Elvers M, Piekorz RP, Scheller J, Behnke K. | 05/17/2023 |
| Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis. | Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis.
Bao J, Zhang P, Wu B, Wang J, Li S, Li A, Jie Y., Free PMC Article | 04/12/2023 |
| Inhibition of gp130 alleviates LPS-induced lung injury by attenuating apoptosis and inflammation through JAK1/STAT3 signaling pathway. | Inhibition of gp130 alleviates LPS-induced lung injury by attenuating apoptosis and inflammation through JAK1/STAT3 signaling pathway.
Xu F, Wang S, Wang Y, Hu L, Zhu L. | 03/21/2023 |
| Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice. | Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.
Namiki T, Terakawa J, Karakama H, Noguchi M, Murakami H, Hasegawa Y, Ohara O, Daikoku T, Ito J, Kashiwazaki N., Free PMC Article | 01/21/2023 |
| Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart. | Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart.
Kawagishi H, Nakada T, Numaga-Tomita T, Larrañaga M, Guo A, Song LS, Yamada M. | 06/18/2022 |
| Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain. | Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain.
Kalpachidou T, Malsch P, Qi Y, Mair N, Geley S, Quarta S, Kummer KK, Kress M., Free PMC Article | 04/16/2022 |
| Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling. | Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling.
van Krieken PP, Odermatt TS, Borsigova M, Blüher M, Wueest S, Konrad D., Free PMC Article | 03/26/2022 |
| gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes. | gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D., Free PMC Article | 03/5/2022 |
| gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration. | gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration.
Li Y, Feng J, Song S, Li H, Yang H, Zhou B, Li Y, Yue Z, Lian H, Liu L, Hu S, Nie Y. | 09/4/2021 |
| Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice. | Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice.
Shi W, Ma H, Liu T, Yan D, Luo P, Zhai M, Tao J, Huo S, Guo J, Li C, Lin J, Zhang C, Li S, Lv J, Lin L., Free PMC Article | 05/1/2021 |
| Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes. | Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes.
Walker EC, Truong K, McGregor NE, Poulton IJ, Isojima T, Gooi JH, Martin TJ, Sims NA., Free PMC Article | 03/20/2021 |
| gp130 is a key regulator of immune homeostasis during sepsis | Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis.
Sackett SD, Otto T, Mohs A, Sander LE, Strauch S, Streetz KL, Kroy DC, Trautwein C. | 06/6/2020 |
| Shortening of the stalk region of gp130 alone did, however, not result in constitutive receptor activation. | Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130.
Lamertz L, Floss DM, Scheller J. | 10/26/2019 |
| Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension. | Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension.
Tamura Y, Phan C, Tu L, Le Hiress M, Thuillet R, Jutant EM, Fadel E, Savale L, Huertas A, Humbert M, Guignabert C., Free PMC Article | 09/14/2019 |
| results demonstrate that gp130-associated TRAF2 and TRAF5 inhibit the interaction between two JAK proteins in the IL-6R complex that is essential for initiating the JAK-STAT signaling pathway | TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.
Kimura M, Nagashima H, Okuyama Y, Ishii N, So T. | 08/17/2019 |
| Different pathology in macrophage/neutrophil- and CD4 T cell-specific gp130-deficient mice suggests that gp130 cytokines modulate TH17 inflammation differentially by targeting distinct cell types. | Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice.
Holz K, Prinz M, Brendecke SM, Hölscher A, Deng F, Mitrücker HW, Rose-John S, Hölscher C., Free PMC Article | 06/15/2019 |
| This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease. | A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2.
Chan B, Clasquin M, Smolen GA, Histen G, Powe J, Chen Y, Lin Z, Lu C, Liu Y, Cang Y, Yan Z, Xia Y, Thompson R, Singleton C, Dorsch M, Silverman L, Su SM, Freeze HH, Jin S., Free PMC Article | 09/30/2017 |
| EBI3 can mediate IL-6 trans-signaling in a process that involves gp130 | Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling.
Chehboun S, Labrecque-Carbonneau J, Pasquin S, Meliani Y, Meddah B, Ferlin W, Sharma M, Tormo A, Masson JF, Gauchat JF., Free PMC Article | 06/24/2017 |
| data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 trans-signaling. | Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.
Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C., Free PMC Article | 05/13/2017 |
| Blocking IL-6 trans-signaling in the CNS abrogates the ability of IL-6 to suppress feeding. Furthermore, gp130 expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 in the PVH attenuates the beneficial central IL-6 effects on metabolism | IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.
Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC. | 05/6/2017 |
| C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. | Lipoic Acid Exerts Antioxidant and Anti-inflammatory Effects in Response to Heat Shock in C2C12 Myotubes.
Lee CT, Chang LC, Wu PF. | 03/11/2017 |
| Results suggest that the protective role of gp130-dependent STAT3 activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells. | Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells.
Däbritz J, Judd LM, Chalinor HV, Menheniott TR, Giraud AS., Free PMC Article | 01/14/2017 |