| KPNB1 modulates the Machado-Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP. | KPNB1 modulates the Machado-Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP.
Abeditashi M, Weber JJ, Pereira Sena P, Velic A, Kalimeri M, Incebacak Eltemur RD, Schmidt J, Hübener-Schmid J, Hauser S, Macek B, Riess O, Schmidt T., Free PMC Article | 07/16/2022 |
| KPNb1 acts as a positive regulator in the NF-kappaB pathway to enhance palmitate-induced inflammation response. | KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes.
Wang S, Zhao Y, Xia N, Zhang W, Tang Z, Wang C, Zhu X, Cui S. | 09/24/2016 |
| KPNB1 may play a key role in the inflammation process of rheumatoid arthritis via STAT3 signal transduction pathway. | The importin protein karyopherin-β1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor.
Sun C, Yu Z, Wang Y, Tao T. | 08/6/2016 |
| The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100. | The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100.
Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z., Free PMC Article | 11/7/2015 |
| Ei24 can bind specifically to IMPbeta1 and IMPalpha2 to impede their normal role in nuclear import. | The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.
Lieu KG, Shim EH, Wang J, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA., Free PMC Article | 06/28/2014 |
| Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein. | Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.
Desmond CR, Atwal RS, Xia J, Truant R., Free PMC Article | 02/23/2013 |
| translation of Importin beta1 mRNA enables separation of cytoplasmic and nuclear transport functions of importins and is required for efficient retrograde signaling in injured axons. | Subcellular knockout of importin β1 perturbs axonal retrograde signaling.
Perry RB, Doron-Mandel E, Iavnilovitch E, Rishal I, Dagan SY, Tsoory M, Coppola G, McDonald MK, Gomes C, Geschwind DH, Twiss JL, Yaron A, Fainzilber M., Free PMC Article | 10/27/2012 |
| A critical function of RanBP2 is to capture recycling RanGTP-importin-beta complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import. | Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.
Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Wälde S, Joseph J, Kehlenbach RH, van Deursen JM., Free PMC Article | 10/15/2011 |
| Ap4A hydrolase was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta | Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.
Carmi-Levy I, Motzik A, Ofir-Birin Y, Yagil Z, Yang CM, Kemeny DM, Han JM, Kim S, Kay G, Nechushtan H, Suzuki R, Rivera J, Razin E., Free PMC Article | 07/2/2011 |
| Data show that MRTF-A contains an unusually long bipartite nuclear localisation signal embedded within the RPEL domain, that uses the importin (Imp)alpha/beta-dependent import pathway, and that import is inhibited by G-actin. | An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.
Pawłowski R, Rajakylä EK, Vartiainen MK, Treisman R., Free PMC Article | 11/27/2010 |
| Dtaa show that importin beta and the integral nuclear pore glycoprotein Nup62 interact with hsp90, hsp70, p23, and the TPR domain proteins FKBP52 and PP5 during nuclear transport. | Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
Echeverría PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, Galigniana MD., Free PMC Article | 01/21/2010 |
| reduction of the affinity by RanGTP really occurs at the nucleoplasmic side of the entire nuclear pore complex | Individual binding pockets of importin-beta for FG-nucleoporins have different binding properties and different sensitivities to RanGTP.
Otsuka S, Iwasaka S, Yoneda Y, Takeyasu K, Yoshimura SH., Free PMC Article | 01/21/2010 |
| Importin beta1 protein is detected in selected germ and somatic cells in fetal gonads, with a striking perinuclear staining evident from embryonic day (E) 14.5 within testicular gonocytes | Subcellular distribution of importins correlates with germ cell maturation.
Hogarth CA, Jans DA, Loveland KL. | 01/21/2010 |
| PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm | Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.
Pickard BW, Hodsman AB, Fraher LJ, Watson PH. | 01/21/2010 |
| results show the crystal structure of importin-beta complexed with the active form of SREBP-2 | The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor.
Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y. | 01/21/2010 |
| These results demonstrated that the cause of post-implantation lethality of Ayu8108(geo/geo) homozygous embryos was impaired expression of the Kpnb1 gene. | Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality.
Miura K, Yoshinobu K, Imaizumi T, Haruna K, Miyamoto Y, Yoneda Y, Nakagata N, Araki M, Miyakawa T, Yamamura K, Araki K. | 01/21/2010 |
| Importin-beta features many more binding spots for nucleoporins than suspected so far. | Binding dynamics of isolated nucleoporin repeat regions to importin-beta.
Isgro TA, Schulten K. | 01/21/2010 |
| Results suggest that the importin alpha/beta system is involved in nuclear entry of mammalian clock components Cry2 and Per2, which is indispensable to transcriptional oscillation of clock genes | Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
Sakakida Y, Miyamoto Y, Nagoshi E, Akashi M, Nakamura TJ, Mamine T, Kasahara M, Minami Y, Yoneda Y, Takumi T. | 01/21/2010 |