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    Irf4 interferon regulatory factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 16364, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions.

    Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions.
    Ochiai K, Shima H, Tamahara T, Sugie N, Funayama R, Nakayama K, Kurosaki T, Igarashi K., Free PMC Article

    08/15/2024
    Interferon Regulatory Factor 4 (IRF4) Plays a Key Role in Osteoblast Differentiation of Postmenopausal Osteoporosis.

    Interferon Regulatory Factor 4 (IRF4) Plays a Key Role in Osteoblast Differentiation of Postmenopausal Osteoporosis.
    Wu X, Yang C, Chen X, Shan Z, Wu X.

    04/3/2024
    Control of nutrient uptake by IRF4 orchestrates innate immune memory.

    Control of nutrient uptake by IRF4 orchestrates innate immune memory.
    Santosa EK, Kim H, Rückert T, Le Luduec JB, Abbasi AJ, Wingert CK, Peters L, Frost JN, Hsu KC, Romagnani C, Sun JC., Free PMC Article

    03/18/2024
    IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.

    IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
    Wang J, Wu Z, Huang Y, Jin L, Xu J, Yao Z, Ouyang X, Zhou Z, Mao S, Cao J, Lai B, Shen W.

    03/13/2024
    IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3.

    IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3.
    Zhu Y, He L, Zhu Y, Yao H, Jiang J, Lu H., Free PMC Article

    01/16/2024
    RNA-seq analysis revealed genes associated with neuropathic pain induced by chronic compressive injury in interferon regulatory factors 4 knockout mice.

    RNA-seq analysis revealed genes associated with neuropathic pain induced by chronic compressive injury in interferon regulatory factors 4 knockout mice.
    Peng J, Wu Y, E Q, Zhou Z, Wen X.

    12/20/2023
    Pellino 3 promotes the colitis-associated colorectal cancer through suppression of IRF4-mediated negative regulation of TLR4 signalling.

    Pellino 3 promotes the colitis-associated colorectal cancer through suppression of IRF4-mediated negative regulation of TLR4 signalling.
    Kim YM, Kim HY, Ha Thi HT, Kim J, Lee YJ, Kim SJ, Hong S., Free PMC Article

    11/7/2023
    IRF4 is required for migration of CD4[+] T cells to the intestine but not for Th2 and Th17 cell maintenance.

    IRF4 is required for migration of CD4(+) T cells to the intestine but not for Th2 and Th17 cell maintenance.
    Schmidt C, Harberts A, Reimers D, Bertram T, Voß LC, Schmid J, Lory NC, Spohn M, Koch-Nolte F, Huber S, Raczkowski F, Breloer M, Mittrücker HW., Free PMC Article

    07/21/2023
    T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.

    T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
    Chen Y, Liu Z, Liu F, Xu L, Li G, Qiao W, Wang Y, Dong N.

    06/22/2023
    Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.

    Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
    Gao Y, Liu B, Guo X, Nie J, Zou H, Wen S, Yu W, Liang H.

    04/7/2023
    IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses.

    IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses.
    Camacho DF, Velez TE, Hollinger MK, Wang E, Howard CL, Darnell EP, Kennedy DE, Krishack PA, Hrusch CL, Clark MR, Moon JJ, Sperling AI., Free PMC Article

    11/19/2022
    IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.

    IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
    Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, Raifer H, Menke L, Hansal L, Camara B, Roth E, Daum P, Wanzel M, Mernberger M, Nist A, Bauer UM, Helmprobst F, Buchholz M, Roth K, Bastian L, Hartmann AM, Baldus C, Ikuta K, Neubauer A, Burchert A, Jäck HM, Klein M, Bopp T, Stiewe T, Pagenstecher A, Lohoff M., Free PMC Article

    11/5/2022
    Unraveling the Structure-Dependent Inhibitory Effects of Ginsenoside Series Compounds on Human Cytochrome P450 1B1.

    Unraveling the Structure-Dependent Inhibitory Effects of Ginsenoside Series Compounds on Human Cytochrome P450 1B1.
    Zhao T, Chen X, Yu H, Du J, Wang D, Wang C, Meng Q, Sun H, Liu K, Wu J.

    10/29/2022
    Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis.

    Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis.
    Liang H, Liu B, Gao Y, Nie J, Feng S, Yu W, Wen S, Su X., Free PMC Article

    10/1/2022
    Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4.

    Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4.
    Masaki S, Watanabe T, Arai Y, Sekai I, Hara A, Kurimoto M, Otsuka Y, Masuta Y, Yoshikawa T, Takada R, Kamata K, Minaga K, Yamashita K, Kudo M., Free PMC Article

    05/21/2022
    Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis.

    Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis.
    Sasaki K, Terker AS, Tang J, Cao S, Arroyo JP, Niu A, Wang S, Fan X, Zhang Y, Bennett SR, Zhang MZ, Harris RC., Free PMC Article

    04/2/2022
    Batf-mediated epigenetic control of effector CD8(+) T cell differentiation.

    Batf-mediated epigenetic control of effector CD8(+) T cell differentiation.
    Tsao HW, Kaminski J, Kurachi M, Barnitz RA, DiIorio MA, LaFleur MW, Ise W, Kurosaki T, Wherry EJ, Haining WN, Yosef N.

    03/12/2022
    Estrogen enhanced the expression of IL-17 by tissue-resident memory gammadeltaT cells from uterus via interferon regulatory factor 4.

    Estrogen enhanced the expression of IL-17 by tissue-resident memory γδT cells from uterus via interferon regulatory factor 4.
    Kang S, Wu Q, Yang B, Wu C.

    02/19/2022
    IRF4 Has a Unique Role in Early B Cell Development and Acts Prior to CD21 Expression to Control Marginal Zone B Cell Numbers.

    IRF4 Has a Unique Role in Early B Cell Development and Acts Prior to CD21 Expression to Control Marginal Zone B Cell Numbers.
    Ottens K, Satterthwaite AB., Free PMC Article

    02/19/2022
    IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury.

    IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury.
    Chen M, Wen X, Gao Y, Liu B, Zhong C, Nie J, Liang H.

    02/12/2022
    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.

    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.
    Bae S, Park PSU, Lee Y, Mun SH, Giannopoulou E, Fujii T, Lee KP, Violante SN, Cross JR, Park-Min KH., Free PMC Article

    02/12/2022
    Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.

    Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.
    Wang L, Zheng ZG, Meng L, Zhu L, Li P, Chen J, Yang H.

    12/25/2021
    Interferon regulatory factor 4 controls effector functions of CD8(+) memory T cells.

    Interferon regulatory factor 4 controls effector functions of CD8(+) memory T cells.
    Harberts A, Schmidt C, Schmid J, Reimers D, Koch-Nolte F, Mittrücker HW, Raczkowski F., Free PMC Article

    12/11/2021
    Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9(+) T Cells.

    Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9(+) T Cells.
    Majumder S, Jugovic I, Saul D, Bell L, Hundhausen N, Seal R, Beilhack A, Rosenwald A, Mougiakakos D, Berberich-Siebelt F., Free PMC Article

    10/30/2021
    Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4.

    Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4.
    Fujii K, Tanaka S, Hasegawa T, Narazaki M, Kumanogoh A, Koseki H, Kurosaki T, Ise W.

    10/2/2021
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