| Acute contact with profibrotic macrophages mechanically activates fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1. | Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1.
Ezzo M, Spindler K, Wang JB, Lee D, Pecoraro G, Cowen J, Pakshir P, Hinz B., Free PMC Article | 10/31/2024 |
| IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin alpha5/FAK in diabetic kidney disease. | IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease.
Wang X, Zhang Y, Chi K, Ji Y, Zhang K, Li P, Fu Z, Wang X, Cui S, Shen W, Cai G, Chen X, Zhu H, Hong Q. | 08/21/2024 |
| A proteomics approach to isolating neuropilin-dependent alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells. | A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells.
Benwell CJ, Johnson RT, Taylor JAGE, Lambert J, Robinson SD., Free PMC Article | 06/12/2024 |
| Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1. | Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.
Łabędź-Masłowska A, Vergori L, Kędracka-Krok S, Karnas E, Bobis-Wozowicz S, Sekuła-Stryjewska M, Sarna M, Andriantsitohaina R, Zuba-Surma EK., Free PMC Article | 02/20/2024 |
| Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin. | Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin.
Kim EY, Dryer SE., Free PMC Article | 02/9/2024 |
| gamma-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin alpha5. | γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5.
Chen W, Yu H, Sun C, Dong M, Zhao N, Wang Y, Yu K, Zhang J, Xu N, Liu W. | 08/11/2023 |
| Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through alpha5 integrin signaling. | Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling.
Li X, McLain C, Samuel MS, Olson MF, Radice GL., Free PMC Article | 01/28/2023 |
| SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway. | SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.
Li BY, Guo YY, Xiao G, Guo L, Tang QQ., Free PMC Article | 06/25/2022 |
| FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway. | FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway.
Liu G, Xu X, Geng H, Li J, Zou S, Li X. | 06/11/2022 |
| The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice. | The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice.
Liu Y, Li Y, Liang J, Sun Z, Wu Q, Liu Y, Sun C., Free PMC Article | 12/18/2021 |
| RhoJ Regulates alpha5beta1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis. | RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
Sundararaman A, Fukushima Y, Norman JC, Uemura A, Mellor H. | 08/14/2021 |
| Coupling of Integrin alpha5 to Annexin A2 by Flow Drives Endothelial Activation. | Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation.
Zhang C, Zhou T, Chen Z, Yan M, Li B, Lv H, Wang C, Xiang S, Shi L, Zhu Y, Ai D. | 05/29/2021 |
| B Cell alphav Integrins Regulate TLR-Driven Autoimmunity. | B Cell αv Integrins Regulate TLR-Driven Autoimmunity.
Acharya M, Raso F, Sagadiev S, Gilbertson E, Kadavy L, Li QZ, Yan M, Stuart LM, Hamerman JA, Lacy-Hulbert A., Free PMC Article | 04/3/2021 |
| Adhesion to fibronectin via alpha5beta1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. | Adhesion to fibronectin via α5β1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis.
Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K., Free PMC Article | 02/20/2021 |
| Angiopoietin-2-integrin alpha5beta1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance. | Angiopoietin-2-integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance.
Bae H, Hong KY, Lee CK, Jang C, Lee SJ, Choe K, Offermanns S, He Y, Lee HJ, Koh GY., Free PMC Article | 08/29/2020 |
| Reappraising the role of alpha5 integrin and the microenvironmental support in stress erythropoiesis. | Reappraising the role of α5 integrin and the microenvironmental support in stress erythropoiesis.
Ulyanova T, Georgolopoulos G, Papayannopoulou T., Free PMC Article | 07/18/2020 |
| Blocking the fibronectin-Integrin alpha5 pathway reduces atherosclerotic plaque size, maintains plaque stability, and improves compensatory remodeling. | Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.
Budatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA., Free PMC Article | 12/14/2019 |
| Endothelial alpha5beta1 integrins drive oxLDL-induced FN deposition and early atherogenic inflammation. | Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation.
Al-Yafeai Z, Yurdagul A Jr, Peretik JM, Alfaidi M, Murphy PA, Orr AW., Free PMC Article | 08/10/2019 |
| The Ang1/Tie2 system cross-talks with integrin alpha5beta1 in brain endothelial cells after cerebral ischemia. | Integrin α5β1-Ang1/Tie2 receptor cross-talk regulates brain endothelial cell responses following cerebral ischemia.
Pang D, Wang L, Dong J, Lai X, Huang Q, Milner R, Li L., Free PMC Article | 05/18/2019 |
| A dual-specific MCSF antagonist of c-FMS and integrin alpha5beta3 prevents the progression of osteoporosis. | A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy.
Zur Y, Rosenfeld L, Keshelman CA, Dalal N, Guterman-Ram G, Orenbuch A, Einav Y, Levaot N, Papo N., Free PMC Article | 05/11/2019 |
| integrin alpha 5 (ITGA5) as one key functional miR-205 target in the re-epithelialization process and epidermal downregulation of miR-205 may desilence ITGA5 to promote keratinocyte migration. | Downregulation of miR-205 in migrating epithelial tongue facilitates skin wound re-epithelialization by derepressing ITGA5.
Wang T, Zhao N, Long S, Ge L, Wang A, Sun H, Ran X, Zou Z, Wang J, Su Y. | 03/30/2019 |
| kindlin-2 interactions with alphaVbeta3 and its other binding partners promote endothelial cell functions potentially relevant to angiogenesis | Optogenetic interrogation of integrin αVβ3 function in endothelial cells.
Liao Z, Kasirer-Friede A, Shattil SJ., Free PMC Article | 06/9/2018 |
| Data suggest that WISP1-alphavbeta3 integrin signaling is involved in Toll-Like Receptor 4 (TLR4) pathways in macrophages. | WISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury.
Chen Z, Ding X, Jin S, Pitt B, Zhang L, Billiar T, Li Q., Free PMC Article | 05/19/2018 |
| loss of alpha5 integrin-mediated fibrillogenesis interferes with the normal cytoskeleton organization that facilitates epithelial cysts polarization. | α5β1 integrin mediates pulmonary epithelial cyst formation.
Legan SK, Lee DD, Schwarz MA., Free PMC Article | 03/3/2018 |
| The findings provide insights into how integrin alphaVbeta3 acts as a molecular machine and how its physiological function and molecular structure are coupled at the single-molecule level. | Force regulated conformational change of integrin α(V)β(3).
Chen Y, Lee H, Tong H, Schwartz M, Zhu C., Free PMC Article | 03/3/2018 |