| Analysis of the role of irisin receptor signaling in regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells. | Analysis of the role of irisin receptor signaling in regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells.
Zhu J, Li J, Yao T, Li T, Chang B, Yi X. | 10/25/2024 |
| Integrin beta5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy. | Integrin β5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy.
Lin X, Huang S, Gao S, Liu J, Tang J, Yu M., Free PMC Article | 03/13/2024 |
| PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin. | PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K., Free PMC Article | 02/27/2024 |
| Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin alphaV/beta5 in Parkinson's Disease. | Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease.
Tang C, Liu M, Zhou Z, Li H, Yang C, Yang L, Xiang J., Free PMC Article | 05/19/2023 |
| Autoregulation of insulin receptor signaling through MFGE8 and the alphavbeta5 integrin. | Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K., Free PMC Article | 12/4/2021 |
| Tumor-penetrating therapy for beta5 integrin-rich pancreas cancer. | Tumor-penetrating therapy for β5 integrin-rich pancreas cancer.
Hurtado de Mendoza T, Mose ES, Botta GP, Braun GB, Kotamraju VR, French RP, Suzuki K, Miyamura N, Teesalu T, Ruoslahti E, Lowy AM, Sugahara KN., Free PMC Article | 04/13/2021 |
| mice lacking alphavbeta5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that alphavbeta5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages | Expression and characterization of αvβ5 integrin on intestinal macrophages.
Kumawat AK, Yu C, Mann EA, Schridde A, Finnemann SC, Mowat AM., Free PMC Article | 02/16/2019 |
| Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3/FAK/AKT signaling pathway. | Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Jia D, Zhu Q, Liu H, Zuo C, He Y, Chen G, Lu A. | 11/4/2017 |
| Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM. | Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice.
Beier JI, Guo L, Ritzenthaler JD, Joshi-Barve S, Roman J, Arteel GE., Free PMC Article | 03/4/2017 |
| Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation. | CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.
Kim KH, Chen CC, Alpini G, Lau LF., Free PMC Article | 08/22/2015 |
| Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration | FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration.
Liu Y, Guan L, Zhan J, Lu D, Wan J, Zhang H. | 10/18/2014 |
| Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. | Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.
Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV., Free PMC Article | 06/7/2014 |
| Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity. | Saccharomyces boulardii improves intestinal epithelial cell restitution by inhibiting αvβ5 integrin activation state.
Canonici A, Pellegrino E, Siret C, Terciolo C, Czerucka D, Bastonero S, Marvaldi J, Lombardo D, Rigot V, André F., Free PMC Article | 03/2/2013 |
| Phosphatidylserine-marked tips do not vary in mice lacking the diurnal phagocytic rhythm of the retinal epithelium due to loss of either alphavbeta5 integrin, or its extracellular ligand milk fat globule-EGF factor 8. | Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.
Ruggiero L, Connor MP, Chen J, Langen R, Finnemann SC., Free PMC Article | 08/4/2012 |
| Data suggest that the alphavbeta3 and alphavbeta5 integrins are not essential for mediating microglial activation responses to vitronectin, but that microglia use multiple redundant receptors to mediate interactions with this ECM protein. | Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins.
Welser-Alves JV, Boroujerdi A, Tigges U, Milner R., Free PMC Article | 04/21/2012 |
| Absence of RG2 does not affect the retinal architecture that requires alphavbeta5 integrins. | αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.
Ruggiero L, Sarang Z, Szondy Z, Finnemann SC., Free PMC Article | 04/14/2012 |
| The exclusive apical distribution of alphavbeta5 integrin receptors in the retinal pigment epithelium, is discussed. | Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.
Mallavarapu M, Finnemann SC., Free PMC Article | 09/17/2011 |
| Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration. | Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
Goh YY, Pal M, Chong HC, Zhu P, Tan MJ, Punugu L, Lam CR, Yau YH, Tan CK, Huang RL, Tan SM, Tang MB, Ding JL, Kersten S, Tan NS., Free PMC Article | 03/19/2011 |
| There is a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced acute lung injury. | Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF., Free PMC Article | 07/16/2010 |
| Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway | Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway.
Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN., Free PMC Article | 04/19/2010 |
| microglia express alphavbeta3 & alphavbeta5 integrins; expression is independently regulated by cytokines & extracellular matrix proteins; alphavbeta5 integrin not essential for mediating microglial adhesion & MMP-9 expression in response to vitronectin | Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin.
Milner R. | 01/21/2010 |
| The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived. | Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC., Free PMC Article | 01/21/2010 |
| alpha(5)beta(1)-integrin is an important regulator of type I collagen production in early primary hepatic stellate cell (HSC) cultures but appears to have no direct role once the HSC are fully activated. | Differences in regulation of type I collagen synthesis in primary and passaged hepatic stellate cell cultures: the role of alpha5beta1-integrin.
Dodig M, Ogunwale B, Dasarathy S, Li M, Wang B, McCullough AJ. | 01/21/2010 |
| MFG-E8 stimulates rhythmic photoreceptor outer segment fragments phagocytosis by ligating apical alphavbeta5 receptors of the retinal pigment epithelium. | Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.
Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC., Free PMC Article | 01/21/2010 |
| Integrin beta 5 knock-out mice demonstrated profoundly accelerated bone loss in the estrogene deplete state. | Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.
Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. | 01/21/2010 |