| The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice. | The integrin receptor beta(7) subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice.
Assayag M, Obedeyah T, Abutbul A, Berkman N., Free PMC Article | 08/8/2024 |
| The protective roles of integrin alpha4beta7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis. | The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis.
Ryu S, Kim KA, Kim J, Lee DH, Bae YS, Lee H, Kim BC, Kim HY., Free PMC Article | 07/2/2024 |
| Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow. | Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Kamioka Y, Ueda Y, Kondo N, Tokuhiro K, Ikeda Y, Bergmeier W, Kinashi T., Free PMC Article | 10/12/2023 |
| An integrin alphaEbeta7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium. | An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium.
Guzman M, Lundborg LR, Yeasmin S, Tyler CJ, Zgajnar NR, Taupin V, Dobaczewska K, Mikulski Z, Bamias G, Rivera-Nieves J., Free PMC Article | 03/19/2022 |
| Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease. | Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T., Free PMC Article | 03/5/2022 |
| beta7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25(hi)FoxP3(+) Regulatory T Cells. | β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25(hi)FoxP3(+) Regulatory T Cells.
Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH., Free PMC Article | 05/8/2021 |
| Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome. | Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.
Pilarowski GO, Cazares T, Zhang L, Benjamin JS, Liu K, Jagannathan S, Mousa N, Kasten J, Barski A, Lindsley AW, Bjornsson HT. | 12/5/2020 |
| Transmission of integrin beta7 transmembrane domain topology enables gut lymphoid tissue development. | Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.
Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH., Free PMC Article | 03/23/2019 |
| lack of beta7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival. | β7 integrins contribute to intestinal tumor growth in mice.
Das S, Doñas C, Akeus P, Quiding-Järbrink M, Mora JR, Villablanca EJ., Free PMC Article | 03/9/2019 |
| Loss of MAdCAM-1 has beneficial effects regarding the development of NASH - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis. | β(7)-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.
Drescher HK, Schippers A, Clahsen T, Sahin H, Noels H, Hornef M, Wagner N, Trautwein C, Streetz KL, Kroy DC. | 03/24/2018 |
| AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD. | Blockade of αEβ7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF. | 10/21/2017 |
| Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin. | Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin.
Chand S, Messina EL, AlSalmi W, Ananthaswamy N, Gao G, Uritskiy G, Padilla-Sanchez V, Mahalingam M, Peachman KK, Robb ML, Rao M, Rao VB., Free PMC Article | 08/19/2017 |
| beta7 integrin, when expressed by hematopoietic stem cells (HSC), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC homing and engraftment. | Evidence that β7 Integrin Regulates Hematopoietic Stem Cell Homing and Engraftment Through Interaction with MAdCAM-1.
Murakami JL, Xu B, Franco CB, Hu X, Galli SJ, Weissman IL, Chen CC., Free PMC Article | 10/8/2016 |
| CCR9 and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue. | Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver.
Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C. | 08/20/2016 |
| Data indicate a role of integrin alpha4beta7 (alpha4beta7) in diet-induced atherosclerosis. | α4β7 Integrin (LPAM-1) is upregulated at atherosclerotic lesions and is involved in atherosclerosis progression.
Zhi K, Li M, Zhang X, Gao Z, Bai J, Wu Y, Zhou S, Li M, Qu L. | 09/26/2015 |
| The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Beta-7 integrin controls enterocyte migration in the small intestine.
Kaemmerer E, Kuhn P, Schneider U, Clahsen T, Jeon MK, Klaus C, Andruszkow J, Härer M, Ernst S, Schippers A, Wagner N, Gassler N., Free PMC Article | 09/26/2015 |
| alpha4beta7 serves as an attachment factor for some HIV-1 strains. | Binding of HIV-1 virions to α4β 7 expressing cells and impact of antagonizing α4β 7 on HIV-1 infection of primary CD4+ T cells.
Li C, Jin W, Du T, Wu B, Liu Y, Shattock RJ, Hu Q., Free PMC Article | 09/5/2015 |
| KLF3 acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation. | Leukocyte β7 integrin targeted by Krüppel-like factors.
Alles M, Turchinovich G, Zhang P, Schuh W, Agenès F, Kirberg J. | 10/25/2014 |
| Mice lacking beta7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of beta7 integrins to reconstitute gut mononuclear phagocytes with tolerogenic potential. | β7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential.
Villablanca EJ, De Calisto J, Torregrosa Paredes P, Cassani B, Nguyen DD, Gabrielsson S, Mora JR. | 10/4/2014 |
| beta7 integrin expression on cells of the innate immune system contributes to the critical role of beta7 integrin in the process of B cell tolerance. | β7 integrin controls immunogenic and tolerogenic mucosal B cell responses.
Schippers A, Kochut A, Pabst O, Frischmann U, Clahsen T, Tenbrock K, Müller W, Wagner N. | 10/20/2012 |
| E-cadherin and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin on keratinocytes | Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cells.
Uchida Y, Kawai K, Ibusuki A, Kanekura T. | 10/8/2011 |
| lack of alpha4beta7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum. | Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection.
Kelly KA, Chan AM, Butch A, Darville T., Free PMC Article | 04/23/2011 |
| gene knock-outs display defective contact hypersensitivity responses due to impaired t cell migration to skin | α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.
Ohmatsu H, Kadono T, Sugaya M, Tomita M, Kai H, Miyagaki T, Saeki H, Tamaki K, Steeber DA, Tedder TF, Sato S. | 04/9/2011 |
| role in migration of B cells into pancreatic lymph nodes in NOD mice | Alpha4beta7 integrin/MAdCAM-1 adhesion pathway is crucial for B cell migration into pancreatic lymph nodes in nonobese diabetic mice.
Xu B, Cook RE, Michie SA., Free PMC Article | 03/19/2011 |
| Strong positive reactions for integrin beta7 are seen on the uterine natural killer cell surface from gestational days 8 to 10, mainly on those cells found near the blood vessels, becoming completely negative after the twelfth gestational day. | Immunocytochemical studies of adhesion molecules on mouse UNK cells and their extracellular matrix ligands during mouse pregnancy.
Zavan B, Paffaro AM, Joazeiro PP, Yamada AT, Paffaro VA Jr. | 01/1/2011 |