| The kinase ITK controls a Ca[2+]-mediated switch that balances TH17 and Treg cell differentiation. | The kinase ITK controls a Ca(2+)-mediated switch that balances T(H)17 and T(reg) cell differentiation.
Anannya O, Huang W, August A., | 07/24/2024 |
| Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice. | Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice.
Algahtani MM, Alshehri S, Alqarni SS, Ahmad SF, Al-Harbi NO, Alqarni SA, Alfardan AS, Ibrahim KE, Attia SM, Nadeem A., Free PMC Article | 06/7/2023 |
| Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer. | Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.
Padhye A, Konen JM, Rodriguez BL, Fradette JJ, Ochieng JK, Diao L, Wang J, Lu W, Solis LS, Batra H, Raso MG, Peoples MD, Minelli R, Carugo A, Bristow CA, Gibbons DL., Free PMC Article | 03/26/2022 |
| The Tec Kinase Itk Integrates Naive T Cell Migration and In Vivo Homeostasis. | The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis.
Thelen F, Wissmann S, Ruef N, Stein JV., Free PMC Article | 12/25/2021 |
| Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK. | Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.
Gallagher MP, Conley JM, Vangala P, Garber M, Reboldi A, Berg LJ., Free PMC Article | 12/18/2021 |
| Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads. | Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.
Hallumi E, Shalah R, Lo WL, Corso J, Oz I, Beach D, Wittman S, Isenberg A, Sela M, Urlaub H, Weiss A, Yablonski D., Free PMC Article | 09/18/2021 |
| Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT. | Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT.
Mammadli M, Huang W, Harris R, Sultana A, Cheng Y, Tong W, Pu J, Gentile T, Dsouza S, Yang Q, Bah A, August A, Karimi M., Free PMC Article | 06/26/2021 |
| Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection. | Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection.
Huang L, Ye K, McGee MC, Nidetz NF, Elmore JP, Limper CB, Southard TL, Russell DG, August A, Huang W., Free PMC Article | 11/21/2020 |
| CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. | CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ., Free PMC Article | 10/10/2020 |
| Ibrutinib suppressed phosphorylation of BTK in neutrophils at lower doses and ITK in CD4+T cells at higher doses in CE-treated mice. | Inhibition of Bruton's tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy.
Nadeem A, Ahmad SF, Al-Harbi NO, Ibrahim KE, Siddiqui N, Al-Harbi MM, Attia SM, Bakheet SA. | 07/4/2020 |
| Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic. | ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.
Fuhriman JM, Winge MCG, Haberstock-Debic H, Funk JO, Bradshaw JM, Marinkovich MP. | 05/4/2019 |
| ITK signalling through the Ras/IRF4 pathway is required for functional development of type 1 regulatory T cells. | ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.
Huang W, Solouki S, Koylass N, Zheng SG, August A., Free PMC Article | 01/19/2019 |
| Data show that interleukin-2 inducible T cell kinase (Itk)negatively regulates the development of nTh1 cells that express interferon-gamma (IFNgamma) in a T-bet transcription factor (Tbet) independent manner. | T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.
Kannan AK, Mohinta S, Huang W, Huang L, Koylass N, Appleton JA, August A., Free PMC Article | 12/22/2018 |
| Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency | Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8(+) CTLs.
Kapnick SM, Stinchcombe JC, Griffiths GM, Schwartzberg PL., Free PMC Article | 08/19/2017 |
| Data suggest that the pleckstrin homology domain of Itk functions as a phospholipid bilayer recognition site that localizes Itk to membrane via phosphatidylinositol 3,4,5-trisphosphate (PIP3) binding; this specific binding inhibits the phospho-transfer reaction via an allosteric mechanism. | An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.
Devkota S, Joseph RE, Boyken SE, Fulton DB, Andreotti AH., Free PMC Article | 07/8/2017 |
| pharmacological inhibition of ITK resulted in T cell hyperplasia and the increased production of TH2-type cytokines. | Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA. | 09/17/2016 |
| ITK and BTK regulate thermal homeostasis during septic response through mast cell function in mice. | Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide.
Huang W, Morales JL, Gazivoda VP, August A., Free PMC Article | 09/3/2016 |
| Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases. | A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.
Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ., Free PMC Article | 02/27/2016 |
| This work has important implications for understanding the role of Itk signaling in the development versus function of iNKT cells, Th1, Th2, and Th17 cells. | Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production.
Kannan A, Lee Y, Qi Q, Huang W, Jeong AR, Ohnigian S, August A., Free PMC Article | 10/31/2015 |
| The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. | The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A. | 08/15/2015 |
| Data indicate that the interleukin-2 inducible tyrosine kinase K390R point mutation (Itk-KD) transgenic mice were largely protected from inflammatory symptoms in an Ovalbumin model of airway inflammation. | Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.
Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, Fung S, Smith J, Pedrick M, McKevitt T, Felton L, Morley J, Quint D, Fattah D, Hayes B, Gough J, Solari R., Free PMC Article | 06/27/2015 |
| The Itk pleckstrin homology domain binds to Calmodulin and PI(3,4,5)Pto promote efficient calcium signaling and IL-17A production. | Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH., Free PMC Article | 04/4/2015 |
| Signaling by Itk promotes autoimmunity and CNS inflammation. | Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
Kannan AK, Kim DG, August A, Bynoe MS., Free PMC Article | 03/21/2015 |
| ITK thus regulates the development and function of Tregs. | IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.
Huang W, Jeong AR, Kannan AK, Huang L, August A., Free PMC Article | 12/20/2014 |
| Data indicate that the IL2-inducible T-cell kinase itk(-/-) innate zinc finger protein 145 PLZF(+)CD4(+) T cells express alphabeta TCRs, neither beta2-microglobulin-dependent MHC class I nor any MHC class II molecules are required for their development. | Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.
Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ., Free PMC Article | 10/4/2014 |