| Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels. | Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels.
Li Q, Chen G, Yan J., | 08/16/2024 |
| Study confirms that expression of full-length Slo3 is sperm-specific but warns against developing contraceptive drugs targeting the C-terminal tail of Slo3 channels. | A cytoplasmic Slo3 isoform is expressed in somatic tissues.
Chávez JC, Vicens A, Wrighton DC, Andrade-López K, Beltrán C, Gutiérrez RM, Lippiat JD, Treviño CL. | 03/14/2020 |
| Considering that capacitation-induced hyperpolarization is mediated by SLO3, we evaluated the action of cSrc inhibitors on the heterologously expressed SLO3 channel. | Src Kinase Is the Connecting Player between Protein Kinase A (PKA) Activation and Hyperpolarization through SLO3 Potassium Channel Regulation in Mouse Sperm.
Stival C, La Spina FA, Baró Graf C, Arcelay E, Arranz SE, Ferreira JJ, Le Grand S, Dzikunu VA, Santi CM, Visconti PE, Buffone MG, Krapf D., Free PMC Article | 10/24/2015 |
| These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment. | SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.
Zeng XH, Yang C, Xia XM, Liu M, Lingle CJ., Free PMC Article | 05/2/2015 |
| SLO3 K+ channels have a role in controlling calcium entry through CATSPER channels in sperm | SLO3 K+ channels control calcium entry through CATSPER channels in sperm.
Chávez JC, Ferreira JJ, Butler A, De La Vega Beltrán JL, Treviño CL, Darszon A, Salkoff L, Santi CM., Free PMC Article | 01/24/2015 |
| Using mice lacking both SLO3 and CATSPER1 subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (-/-) sperm is abolished when CATSPER is also deleted. | Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa.
Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ., Free PMC Article | 05/3/2014 |
| SLO3-dependent hyperpolarization | Ion permeabilities in mouse sperm reveal an external trigger for SLO3-dependent hyperpolarization.
Chávez JC, de la Vega-Beltrán JL, Escoffier J, Visconti PE, Treviño CL, Darszon A, Salkoff L, Santi CM., Free PMC Article | 10/26/2013 |
| KSper/Slo3 is the primary spermatozoan K(+) channel, and Slo3 is critical for fertility. | Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa.
Zeng XH, Yang C, Kim ST, Lingle CJ, Xia XM., Free PMC Article | 07/2/2011 |
| Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition | Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition.
Tang QY, Zhang Z, Xia J, Ren D, Logothetis DE., Free PMC Article | 07/26/2010 |
| Compare pharmacological properties of the pH-regulated Slo3 channel and its close homologue, the Slo1 or BK channel. | Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.
Tang QY, Zhang Z, Xia XM, Lingle CJ., Free PMC Article | 07/12/2010 |
| SLO3 is the principal potassium channel responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the acrosome reaction. | The SLO3 sperm-specific potassium channel plays a vital role in male fertility.
Santi CM, Martínez-López P, de la Vega-Beltrán JL, Butler A, Alisio A, Darszon A, Salkoff L., Free PMC Article | 03/22/2010 |
| results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit | Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function.
Yang CT, Zeng XH, Xia XM, Lingle CJ., Free PMC Article | 01/21/2010 |
| analysis of SLO3 K+ channels shows evolutionary divergence for an RCK1 region of critical function | Bovine and mouse SLO3 K+ channels: evolutionary divergence points to an RCK1 region of critical function.
Santi CM, Butler A, Kuhn J, Wei A, Salkoff L., Free PMC Article | 01/21/2010 |
| native current observed in sperm is indeed carried by Slo3 channels. | Mouse sperm K+ currents stimulated by pH and cAMP possibly coded by Slo3 channels.
Martínez-López P, Santi CM, Treviño CL, Ocampo-Gutiérrez AY, Acevedo JJ, Alisio A, Salkoff LB, Darszon A., Free PMC Article | 01/21/2010 |
| a structurally new Mg(2+)-binding site in the RCK/Rossman fold domain -- an intracellular structural motif that immediately follows the activation gate S6 helix -- is responsible for Mg(2+)-dependent activation | Mechanism of magnesium activation of calcium-activated potassium channels.
Shi J, Krishnamoorthy G, Yang Y, Hu L, Chaturvedi N, Harilal D, Qin J, Cui J. | 01/21/2010 |
| increases in pH increase the fraction of more rapidly opening channels. | Slo3 K+ channels: voltage and pH dependence of macroscopic currents.
Zhang X, Zeng X, Lingle CJ., Free PMC Article | 01/21/2010 |
| voltage and pH regulate a closed-open conformational change in a largely independent fashion | pH-regulated Slo3 K+ channels: properties of unitary currents.
Zhang X, Zeng X, Xia XM, Lingle CJ., Free PMC Article | 01/21/2010 |