| Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. | Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair.
Feng LL, Bie SY, Deng ZH, Bai SM, Shi J, Qin CL, Liu HL, Li JX, Chen WY, Zhou JY, Jiao CM, Ma Y, Qiu MB, Ai HS, Zheng J, Hung MC, Wang YL, Wan XB, Fan XJ., | 07/30/2024 |
| Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-kappaB Activation in Lupus Nephritis. | Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis.
Zou L, Sun L, Hua R, Wu Y, Sun L, Chen T., Free PMC Article | 01/4/2024 |
| The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair. | The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, Zhu Q, Liu X, Wang Y, Pei XH, Xu X, Zhang J, Zhu WG., Free PMC Article | 09/26/2023 |
| UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair. | UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.
Lee SO, Kelliher JL, Song W, Tengler K, Sarkar A, Dray E, Leung JWC., Free PMC Article | 09/18/2023 |
| SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer. | SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.
Wei M, Huang X, Liao L, Tian Y, Zheng X. | 09/6/2023 |
| Emerging Roles of RNF168 in Tumor Progression. | Emerging Roles of RNF168 in Tumor Progression.
Xie T, Qin H, Yuan Z, Zhang Y, Li X, Zheng L., Free PMC Article | 02/14/2023 |
| New answers to the old RIDDLE: RNF168 and the DNA damage response pathway. | New answers to the old RIDDLE: RNF168 and the DNA damage response pathway.
Kelliher J, Ghosal G, Leung JWC., Free PMC Article | 05/14/2022 |
| Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease. | Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease.
Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El-Khamisy SF., Free PMC Article | 03/12/2022 |
| RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. | RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.
Katsuki Y, Abe M, Park SY, Wu W, Yabe H, Yabe M, van Attikum H, Nakada S, Ohta T, Seidman MM, Kim Y, Takata M., Free PMC Article | 02/12/2022 |
| RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination. | RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination.
Rong G, Pan Z, Ding M, Wang L. | 02/5/2022 |
| RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage. | RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage.
Krais JJ, Wang Y, Patel P, Basu J, Bernhardy AJ, Johnson N., Free PMC Article | 09/18/2021 |
| RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression. | RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression.
Xu Y, Feng Y, Sun Z, Li Q. | 08/14/2021 |
| RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage. | RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage.
Lu X, Xu M, Zhu Q, Zhang J, Liu G, Bao Y, Gu L, Tian Y, Wen H, Zhu WG. | 07/24/2021 |
| RNF168 is highly expressed in esophageal squamous cell carcinoma and contributes to the malignant behaviors in association with the Wnt/beta-catenin signaling pathway. | RNF168 is highly expressed in esophageal squamous cell carcinoma and contributes to the malignant behaviors in association with the Wnt/β-catenin signaling pathway.
Gou Y, Jin D, He S, Han S, Bai Q., Free PMC Article | 07/24/2021 |
| RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells. | RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.
Nakajima NI, Yamauchi M, Kakoti S, Cuihua L, Kato R, Permata TBM, Iijima M, Yajima H, Yasuhara T, Yamada S, Hasegawa S, Shibata A. | 03/13/2021 |
| SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase. | SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase.
Dulev S, Lin S, Liu Q, Cetintas VB, Batada NN., Free PMC Article | 02/2/2021 |
| E3 ubiquitin ligase RNF168, in addition to its canonical role in inhibiting end resection, acts in a redundant manner with BRCA1 to load PALB2 onto damaged DNA. Loss of RNF168 negates the synthetic rescue of BRCA1 deficiency by 53BP1 deletion | BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.
Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A., Free PMC Article | 09/19/2020 |
| A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. | A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis.
Du C, Hansen LJ, Singh SX, Wang F, Sun R, Moure CJ, Roso K, Greer PK, Yan H, He Y., Free PMC Article | 09/12/2020 |
| Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. | Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination.
Kelliher JL, West KL, Gong Q, Leung JWC., Free PMC Article | 08/15/2020 |
| mmuno-precipitation reveals that RNF168 associates with STAT1 in the nucleus, stabilizing STAT1 protein and inhibiting its poly-ubiquitination and degradation. Our study provides a novel mechanism that RNF168 promoting JAK-STAT signalling in supporting oesophageal cancer progression. It could be a promising strategy to target RNF168 for oesophageal cancer treatment. | RNF168 facilitates proliferation and invasion of esophageal carcinoma, possibly via stabilizing STAT1.
Yu N, Xue M, Wang W, Xia D, Li Y, Zhou X, Pang D, Lu K, Hou J, Zhang A, Zhuang T, Wang L, Chang T, Li X., Free PMC Article | 06/20/2020 |
| Study reveals a mechanism by which tumor viruses reshape the cellular response to DNA damage by manipulating RNF168-dependent ubiquitin signaling. Importantly, findings reveal a pathway by which HPV may promote the genomic instability that drives oncogenesis. | Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response.
Sitz J, Blanchet SA, Gameiro SF, Biquand E, Morgan TM, Galloy M, Dessapt J, Lavoie EG, Blondeau A, Smith BC, Mymryk JS, Moody CA, Fradet-Turcotte A., Free PMC Article | 04/25/2020 |
| PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair | PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair.
Vancurova M, Hanzlikova H, Knoblochova L, Kosla J, Majera D, Mistrik M, Burdova K, Hodny Z, Bartek J. | 01/11/2020 |
| USP14 directly interacted with RNF168, which depended on the MIU1 domain of RNF168. These findings identify USP14 as a novel substrate of autophagy and regulation of RNF168-dependent Ubiquitination and TP53BP1 recruitment by USP14 as a critical link between DNA damage repair and autophagy. | USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.
Sharma A, Alswillah T, Singh K, Chatterjee P, Willard B, Venere M, Summers MK, Almasan A., Free PMC Article | 11/2/2019 |
| RNF168 is required for ESR1-positive breast cancer cell proliferation and facilitates ESR1 signaling activity possibly through promoting its transcription. | RNF168 facilitates oestrogen receptor ɑ transcription and drives breast cancer proliferation.
Liu Z, Zhang J, Xu J, Yang H, Li X, Hou Y, Zhao Y, Xue M, Wang B, Yu N, Yu S, Niu G, Wu G, Li X, Wang H, Zhu J, Zhuang T., Free PMC Article | 11/2/2019 |
| data are in line with a model in which HUWE1 primes histone H1 with ubiquitin to allow ubiquitin chain elongation by RNF8, thereby stimulating the RNF8-RNF168 mediated DDR. | DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.
Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA., Free PMC Article | 07/6/2019 |