| Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis. | Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.
Wang JK, Li Y, Zhao XL, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL, Luo J. | 03/12/2022 |
| Circulating PKK confines pro-inflammatory signaling in the lung by a mechanism that does not involve contact system activation, which in the case of respiratory tract infection may impede early protective innate immunity. | Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.
Ding C, Scicluna BP, Stroo I, Yang J, Roelofs JJ, de Boer OJ, de Vos AF, Nürnberg P, Revenko AS, Crosby J, Van't Veer C, van der Poll T., Free PMC Article | 07/11/2020 |
| In ambient particulate matter-induced lung injury model, Klkb1(-/-) mice exhibited a decrease in total protein, cells numbers in bronchoalveolar lavage fluid (BALF) and histologic lung injury score. The TNF-alpha and IL-6 levels in BALF were significantly decreased in ambient particulate matter-treated Klkb1(-/-) mice. | Plasma kallikrein contributes to ambient particulate matter-induced lung injury.
Wang B, Yan X, Chen F, Yang A, Lu Y, Wu Y. | 06/13/2020 |
| Plasma kallikrein is detected in the urine of proteinuria and activates ENaC involving the putative prostasin cleavage site. However, PKLK is not essential for volume retention in nephrotic mice. | Plasma kallikrein activates the epithelial sodium channel in vitro but is not essential for volume retention in nephrotic mice.
Haerteis S, Schork A, Dörffel T, Bohnert BN, Nacken R, Wörn M, Xiao M, Essigke D, Janessa A, Schmaier AH, Feener EP, Häring HU, Bertog M, Korbmacher C, Artunc F. | 11/2/2019 |
| Determination of the crystal structures of a serine protease, murine plasma kallikrein. | Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
Xu M, Chen Y, Xu P, Andreasen PA, Jiang L, Li J, Huang M. | 06/15/2019 |
| Plasma kallikrein-dependent activation of latent TGF-beta in the acute liver injury. | Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β.
Li M, Qin XY, Furutani Y, Inoue I, Sekihara S, Kagechika H, Kojima S. | 06/1/2019 |
| Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke. | Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.
Simão F, Ustunkaya T, Clermont AC, Feener EP., Free PMC Article | 08/19/2017 |
| we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3) and other kallikrein-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins | Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo.
Li S, Garcia M, Gewiss RL, Winuthayanon W., Free PMC Article | 06/3/2017 |
| Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas, prostacyclin, Sirt1, and KLF4 | Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
Stavrou EX, Fang C, Merkulova A, Alhalabi O, Grobe N, Antoniak S, Mackman N, Schmaier AH., Free PMC Article | 03/28/2015 |
| Plasma kallikrein deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. | Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait.
Bird JE, Smith PL, Wang X, Schumacher WA, Barbera F, Revelli JP, Seiffert D. | 10/20/2012 |
| PKK or fXII deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis. | Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.
Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR., Free PMC Article | 01/7/2012 |
| Data suggest that LGG secreting PSA may activate antigen specific immune responses when instilled intravesically and IL15 could enhance this response. | Lactobacilli secreting a tumor antigen and IL15 activates neutrophils and dendritic cells and generates cytotoxic T lymphocytes against cancer cells.
Kandasamy M, Bay BH, Lee YK, Mahendran R. | 12/10/2011 |
| the prekallikrein gene (Klkb1) is expressed highly in the mammary gland during stromal remodeling periods including puberty and postlactational involution. | Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.
Lilla JN, Joshi RV, Craik CS, Werb Z., Free PMC Article | 01/21/2010 |