| In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9. | In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
Tiyaboonchai A, Wakefield L, Vonada A, May CL, Dorrell C, Enicks D, Sairavi A, Kaestner KH, Grompe M. | 11/10/2023 |
| Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells. | Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
Ievlev V, Lynch TJ, Freischlag KW, Gries CB, Shah A, Pai AC, Ahlers BA, Park S, Engelhardt JF, Parekh KR., Free PMC Article | 02/4/2023 |
| Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse. | Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
Tian Q, Wang YY, Li Q, Chen D., Free PMC Article | 07/10/2021 |
| Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3sigma and YAP1. | Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1.
Guo Y, Redmond CJ, Leacock KA, Brovkina MV, Ji S, Jaskula-Ranga V, Coulombe PA., Free PMC Article | 03/20/2021 |
| Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice. | Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
Sundberg JP, Pratt CH, Goodwin LP, Silva KA, Kennedy VE, Potter CS, Dunham A, Sundberg BA, HogenEsch H., Free PMC Article | 09/12/2020 |
| keratin 1 (K1) is essential for the persistent infection caused by LCMV strain MX, and its absence very effectively slows down the course of infection | Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX.
Labudová M, Zdurienčíková M, Fabianová A, Barátová M, Ditte P, Radvak P, Nemčovičová I, Pastoreková S, Pastorek J. | 08/3/2019 |
| Cumulatively, these data indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis in females at least and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions. | Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.
Li YP, Jia XP, Jiang YQ, Wang W, Wang YL, Wang XL, Guo YX., Free PMC Article | 11/10/2018 |
| KRT14 is expressed in a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis. | KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
Papafotiou G, Paraskevopoulou V, Vasilaki E, Kanaki Z, Paschalidis N, Klinakis A., Free PMC Article | 08/25/2018 |
| CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14. | Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
Inaba H, Yamakawa D, Tomono Y, Enomoto A, Mii S, Kasahara K, Goto H, Inagaki M. | 05/5/2018 |
| RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling. | Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
Abashev TM, Metzler MA, Wright DM, Sandell LL., Free PMC Article | 01/13/2018 |
| Analysis of K14 variants with single or multiple substitutions of cysteine residues points to a spatial and temporal hierarchy in how Cys-4/Cys-40 and Cys-367 regulate keratin assembly in vitro and filament dynamics in live keratinocytes | Complementary roles of specific cysteines in keratin 14 toward the assembly, organization, and dynamics of intermediate filaments in skin keratinocytes.
Feng X, Coulombe PA., Free PMC Article | 12/5/2015 |
| Disulfide bonding is a novel and important mechanism regulating the assembly, intracellular organization, and dynamics of K14-containing intermediate filaments in skin keratinocytes. | A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes.
Feng X, Coulombe PA., Free PMC Article | 06/27/2015 |
| K14-VEGF transgenic mouse a valuable model to study novel immunotherapies for psoriasis | Clinical, pathological and immunological features of psoriatic-like lesions affecting keratin 14-vascular endothelial growth factor transgenic mice.
Canavese M, Altruda F, Silengo L, Castiglioni V, Scanziani E, Radaelli E. | 04/30/2011 |
| autoantibodies in Scurfy mice and patients with IPEX target keratin 14 | Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.
Huter EN, Natarajan K, Torgerson TR, Glass DD, Shevach EM., Free PMC Article | 05/31/2010 |
| DeltaNp63 alone can restore the expression of the basal keratins and reinitiate the failed epidermal differentiation program in the skin of p63 null animals. | An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.
Romano RA, Ortt K, Birkaya B, Smalley K, Sinha S., Free PMC Article | 01/21/2010 |
| IL-6 and IFN-gamma stimulated VEGF-A mRNA production in the skin and in primary keratinocytes of keratin 14 IL-4 transgenic mice | The progression of inflammation parallels the dermal angiogenesis in a keratin 14 IL-4-transgenic model of atopic dermatitis.
Chen L, Marble DJ, Agha R, Peterson JD, Becker RP, Jin T, Li J, Chan LS. | 01/21/2010 |
| The keratin-14 IL-4 transgenic (Tg) mouse model of atopic dermatitis (AD) is characterized by skin infiltration of T cells, early up-regulation of T(h)2 cytokines and late surge of T(h)1 cytokines. | CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model.
Chen L, Lin SX, Agha-Majzoub R, Overbergh L, Mathieu C, Chan LS. | 01/21/2010 |
| nipple connective tissue and its development: insights from the keratin 14-PTHrP mouse | Nipple connective tissue and its development: insights from the K14-PTHrP mouse.
Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J. | 01/21/2010 |
| These studies provide a potential mechanism by which deltaNp63 directly governs the expression of K14 in a keratinocyte-specific manner. | A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63.
Romano RA, Birkaya B, Sinha S. | 01/21/2010 |
| Study describes the expression profile of claudins and keratin markers in the accelerated epidermal permeability barrier formation of K14-CaSR transgenic mice during development as compared to the wild type from E12.5 to newborn stages. | The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice.
Troy TC, Li Y, O'Malley L, Turksen K. | 01/21/2010 |