| A dispensable role of mural cell-derived laminin-alpha5 in intracerebral hemorrhage. | A dispensable role of mural cell-derived laminin-α5 in intracerebral hemorrhage.
Ruan J, Kang M, Nirwane A, Yao Y., | 09/13/2024 |
| LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate. | LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate.
Fu Z, Qi Y, Xue LF, Xu YX, Yue J, Zhao JZ, Li C, Xiao W., Free PMC Article | 06/3/2024 |
| Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis. | Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.
Parte S, Kaur AB, Nimmakayala RK, Ogunleye AO, Chirravuri R, Vengoji R, Leon F, Nallasamy P, Rauth S, Alsafwani ZW, Lele S, Cox JL, Bhat I, Singh S, Batra SK, Ponnusamy MP. | 05/10/2024 |
| A dispensable role of oligodendrocyte-derived laminin-alpha5 in brain homeostasis and intracerebral hemorrhage. | A dispensable role of oligodendrocyte-derived laminin-α5 in brain homeostasis and intracerebral hemorrhage.
Kang M, Nirwane A, Ruan J, Adithan A, Gray M, Xu L, Yao Y., | 03/29/2024 |
| Endothelial and mural laminin-alpha5 contributes to neurovascular integrity maintenance. | Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance.
Nirwane A, Kang M, Adithan A, Maharaj V, Nguyen F, Santaella Aguilar E, Nasrollahi A, Yao Y., Free PMC Article | 02/26/2024 |
| A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects. | A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
Kaimori JY, Kikkawa Y, Motooka D, Namba-Hamano T, Takuwa A, Okazaki A, Kobayashi K, Tanigawa A, Kotani Y, Uno Y, Yoshimi K, Hattori K, Asahina Y, Kajimoto S, Doi Y, Oka T, Sakaguchi Y, Mashimo T, Sekiguchi K, Nakaya A, Nomizu M, Isaka Y., Free PMC Article | 03/3/2023 |
| Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions. | Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions.
Liu YC, Ban LK, Lee HH, Lee HT, Chang YT, Lin YT, Su HY, Hsu ST, Higuchi A. | 02/19/2022 |
| Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5. | Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5.
Gou L, Ren X, Ji P. | 02/19/2022 |
| Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin alpha5. | Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5.
Richards M, Pal S, Sjöberg E, Martinsson P, Venkatraman L, Claesson-Welsh L. | 02/12/2022 |
| Regulation and Function of Laminin A5 during Mouse and Human Decidualization. | Regulation and Function of Laminin A5 during Mouse and Human Decidualization.
Yang ZS, Pan HY, Shi WW, Chen ST, Wang Y, Li MY, Zhang HY, Yang C, Liu AX, Yang ZM., Free PMC Article | 02/5/2022 |
| Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk. | Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.
Englund JI, Ritchie A, Blaas L, Cojoc H, Pentinmikko N, Döhla J, Iqbal S, Patarroyo M, Katajisto P., Free PMC Article | 08/7/2021 |
| The lymph node stromal laminin alpha5 shapes alloimmunity. | The lymph node stromal laminin α5 shapes alloimmunity.
Li L, Shirkey MW, Zhang T, Xiong Y, Piao W, Saxena V, Paluskievicz C, Lee Y, Toney N, Cerel BM, Li Q, Simon T, Smith KD, Hippen KL, Blazar BR, Abdi R, Bromberg JS., Free PMC Article | 02/6/2021 |
| Laminin alpha2, alpha4, and alpha5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells. | Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
Suzuki N, Hyodo M, Hayashi C, Mabuchi Y, Sekimoto K, Onchi C, Sekiguchi K, Akazawa C., Free PMC Article | 11/21/2020 |
| In diverse models, laminins alpha-4 (LAMA4) and alpha-5 (LAMA5) were differentially regulated. Immunity was associated with decreased LAMA4:LAMA5 ratio, while tolerance was associated with an increased ratio. LAMA4inhibited CD4+ T-cell proliferation and Th1, Th2, and Th17 polarization but favored Treg induction. LAMA4 and LAMA5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively. | Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS., Free PMC Article | 06/20/2020 |
| Mural cell-derived laminin-alpha5 plays a detrimental role in ischemic stroke. | Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.
Nirwane A, Johnson J, Nguyen B, Miner JH, Yao Y., Free PMC Article | 04/4/2020 |
| Laminin511 controls the differentiation of melanocytes by regulating their migration from the epidermis into hair follicles (HFs) and by activating CXCR4 expression on melanocytes required for their recruitment into HFs in an SDF1-dependent manner. | Dual role of laminin‑511 in regulating melanocyte migration and differentiation.
Üstün Y, Reibetanz M, Brachvogel B, Nischt R, Eckes B, Zigrino P, Krieg T. | 12/7/2019 |
| Immunofluorescence microscopy revealed that laminin-511, -332, and collagen type IV proteins were also significantly increased in psoriasis-like skin lesions of Imiquimod-treated mice. | Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?
Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D., Free PMC Article | 08/3/2019 |
| the overriding effect of laminin 511 in the skin is inhibition of basal keratinocyte proliferation and migration. | Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication.
Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L. | 02/10/2018 |
| Study found that the extracellular matrix protein laminin-511 (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP. | Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP.
Zhang D, Yang S, Toledo EM, Gyllborg D, Saltó C, Carlos Villaescusa J, Arenas E. | 01/13/2018 |
| Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation | Requirement for basement membrane laminin α5 during urethral and external genital development.
Lin C, Werner R, Ma L, Miner JH., Free PMC Article | 12/30/2017 |
| The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress. | Endothelial basement membrane laminin 511 is essential for shear stress response.
Di Russo J, Luik AL, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker EN, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin LM., Free PMC Article | 07/15/2017 |
| According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time. | Different ideas associated renal malformation and laminin α5 expression caused by maternal nicotine exposures.
Shariati Kohbanani M, Taghavi MM, Shabanizadeh A, Jafari Naveh HR, Taghipour Z, Kazemi Arababadi M. | 02/4/2017 |
| Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5) may regulate appropriate hair morphogenesis. | Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis.
Imanishi H, Tsuruta D, Tateishi C, Sugawara K, Kobayashi H, Ishii M, Kishi K. | 11/22/2014 |
| Laminins affect T cell trafficking and allograft fate. | Laminins affect T cell trafficking and allograft fate.
Warren KJ, Iwami D, Harris DG, Bromberg JS, Burrell BE., Free PMC Article | 06/21/2014 |
| Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes. | The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein.
Kikkawa Y, Ogawa T, Sudo R, Yamada Y, Katagiri F, Hozumi K, Nomizu M, Miner JH., Free PMC Article | 01/4/2014 |