| Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function. | Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function.
Reynolds CA, Pelka S, Gjergjova F, Tasset I, Khawaja RR, Lindenau K, Krause GJ, Gavathiotis E, Cuervo AM, Macian F., | 09/17/2024 |
| Transcriptional genes of lysosome-associated membrane protein 2A in sciatic nerve injuries by bioinformatics. | Transcriptional genes of lysosome-associated membrane protein 2A in sciatic nerve injuries by bioinformatics.
Sohn EJ, Park KT. | 08/5/2024 |
| The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. | The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X, Jing Q, Yan C, Han Y., Free PMC Article | 10/4/2023 |
| LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling pathway. | LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/β-catenin/GSK3β signaling pathway.
Wang Y, Hang K, Ying L, Wu J, Wu X, Zhang W, Li L, Wang Z, Bai J, Gao X, Xue D, Pan Z. | 06/29/2023 |
| LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice. | LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice.
Zhang KK, Zhang P, Kodur A, Erturk I, Burns CM, Kenyon C, Miller RA, Endicott SJ., Free PMC Article | 06/28/2023 |
| LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development. | LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.
Rodrigues PM, Sousa LG, Perrod C, Maceiras AR, Ferreirinha P, Pombinho R, Romera-Cárdenas G, Gomez-Lazaro M, Senkara M, Pistolic J, Cabanes D, Klein L, Saftig P, Alves NL., Free PMC Article | 01/21/2023 |
| Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation. | Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation.
Bai FR, Wu QQ, Wu YJ, Hu YQ, Jiang ZX, Lv H, Qian WZ, Cai C, Wu JW., Free PMC Article | 08/13/2022 |
| Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells. | Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells.
Terasawa K, Kato Y, Ikami Y, Sakamoto K, Ohtake K, Kusano S, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Guan JL, Kobayashi T, Iwata T, Watabe T, Yokoyama S, Hara-Yokoyama M., Free PMC Article | 04/16/2022 |
| Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease. | Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease.
Guo W, Zhong W, Hao L, Dong H, Sun X, Yue R, Li T, Zhou Z., Free PMC Article | 04/2/2022 |
| miR221 regulates TGF-beta1-induced HSC activation through inhibiting autophagy by directly targeting LAMP2. | miR221 regulates TGF-β1-induced HSC activation through inhibiting autophagy by directly targeting LAMP2.
Cheng R, Xu H, Hong Y., Free PMC Article | 02/12/2022 |
| Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis. | Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis.
Qiao L, Ma J, Zhang Z, Sui W, Zhai C, Xu D, Wang Z, Lu H, Zhang M, Zhang C, Chen W, Zhang Y., Free PMC Article | 01/8/2022 |
| LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart. | LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart.
Alcalai R, Arad M, Wakimoto H, Yadin D, Gorham J, Wang L, Burns E, Maron BJ, Roberts WC, Konno T, Conner DA, Perez-Atayde AR, Seidman JG, Seidman CE., Free PMC Article | 01/8/2022 |
| LAMP2 deficiency attenuates the neurodegeneration markers induced by HSV-1 infection. | LAMP2 deficiency attenuates the neurodegeneration markers induced by HSV-1 infection.
Kristen H, Sastre I, Aljama S, Fuentes M, Recuero M, Frank-García A, Martin A, Sanchez-Juan P, Lage C, Bullido MJ, Aldudo J. | 12/18/2021 |
| Chaperone-Mediated Autophagy after Spinal Cord Injury. | Chaperone-Mediated Autophagy after Spinal Cord Injury.
Handa K, Kanno H, Matsuda M, Sugaya T, Murakami T, Prudnikova M, Ozawa H, Itoi E. | 11/6/2021 |
| LAMP2A-mediated autophagy involved in Huntington's disease progression. | LAMP2A-mediated autophagy involved in Huntington's disease progression.
Choi SH, Cho K. | 04/24/2021 |
| LAMP-2 Is Involved in Surface Expression of RANKL of Osteoblasts In Vitro. | LAMP-2 Is Involved in Surface Expression of RANKL of Osteoblasts In Vitro.
Jansen IDC, Tigchelaar-Gutter W, Hogervorst JMA, de Vries TJ, Saftig P, Everts V., Free PMC Article | 02/27/2021 |
| Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas. | Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.
Sudhakar JN, Lu HH, Chiang HY, Suen CS, Hwang MJ, Wu SY, Shen CN, Chang YM, Li FA, Liu FT, Shui JW., Free PMC Article | 09/26/2020 |
| miR-207 inhibits autophagy and promotes apoptosis of cardiomyocytes by directly targeting LAMP2, which participates in the development of type 2 diabetic cardiomyopathy | MiR-207 inhibits autophagy and promotes apoptosis of cardiomyocytes by directly targeting LAMP2 in type 2 diabetic cardiomyopathy.
Xing R, Liu D, Cheng X, Tian X, Yan C, Han Y. | 06/27/2020 |
| basal and inducible regulation of LAMP2A, and consequently Chaperone-mediated autophagy activity, by NFE2L2, is reported. | Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.
Pajares M, Rojo AI, Arias E, Díaz-Carretero A, Cuervo AM, Cuadrado A., Free PMC Article | 10/12/2019 |
| High Lamp2 expression is associated with kidney fibrosis. | Protein kinase Cα drives fibroblast activation and kidney fibrosis by stimulating autophagic flux.
Xue X, Ren J, Sun X, Gui Y, Feng Y, Shu B, Wei W, Lu Q, Liang Y, He W, Yang J, Dai C., Free PMC Article | 02/16/2019 |
| Interruption of LAMP-2 expression did not result in an increase of the steady-state protein levels of DJ-1 /PARK7, as it would have been expected. No change in DJ-1 /PARK7 protein levels were observed upon inhibition of lysosomal function with NH4Cl or NH4Cl plus leupeptin, or after activation of CMA by serum starvation for 24h. | Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein.
Sánchez-Lanzas R, Castaño JG., Free PMC Article | 01/19/2019 |
| Lysosomal p38 MAPK directly phosphorylates LAMP2A at T211 and T213, which causes its membrane accumulation and active conformational change, activating chaperone-mediated autophagy. | Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy.
Li W, Zhu J, Dou J, She H, Tao K, Xu H, Yang Q, Mao Z., Free PMC Article | 12/22/2018 |
| Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it. | The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts.
Sakane H, Akasaki K. | 10/20/2018 |
| The results presented here show the major role of LAMP-2 in caveolin traffic and membrane repair and consequently in T. cruzi invasion. | LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion.
Couto NF, Pedersane D, Rezende L, Dias PP, Corbani TL, Bentini LC, Oliveira ACS, Kelles LF, Castro-Gomes T, Andrade LO., Free PMC Article | 07/15/2017 |
| The up-regulation of Rab11, Rab7, or RILP, but not its truncated form RILP-C33, rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 impaired LAMP2A trafficking. | Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD., Free PMC Article | 07/8/2017 |