| Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection. | Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection.
Lind MCH, Naimi WA, Chiarelli TJ, Sparrer T, Ghosh M, Shapiro L, Carlyon JA., Free PMC Article | 10/29/2024 |
| CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery. | CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.
Nguyen JN, Mohan EC, Pandya G, Ali U, Tan C, Kofler JK, Shapiro L, Marrelli SP, Chauhan A., Free PMC Article | 11/2/2023 |
| Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1. | Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.
Tsou PS, Lu C, Gurrea-Rubio M, Muraoka S, Campbell PL, Wu Q, Model EN, Lind ME, Vichaikul S, Mattichak MN, Brodie WD, Hervoso JL, Ory S, Amarista CI, Pervez R, Junginger L, Ali M, Hodish G, O'Mara MM, Ruth JH, Robida AM, Alt AJ, Zhang C, Urquhart AG, Lawton JN, Chung KC, Maerz T, Saunders TL, Groppi VE, Fox DA, Amin MA., Free PMC Article | 06/11/2022 |
| CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis. | CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
Ghosh M, Kelava T, Madunic IV, Kalajzic I, Shapiro LH., Free PMC Article | 11/13/2021 |
| In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide. | In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide.
Kis A, Dénes N, Szabó JP, Arató V, Beke L, Matolay O, Enyedi KN, Méhes G, Mező G, Bai P, Kertész I, Trencsényi G., Free PMC Article | 05/29/2021 |
| ANPEP could be involved in the regulation of endometrial receptivity | Aminopeptidase N expression in the endometrium could affect endometrial receptivity.
Shui LJ, Meng Y, Huang C, Qian Y, Liu JY. | 07/11/2020 |
| Findings indicate a role for cell surface antigen CD13 (CD13) in the fundamental cellular processes of receptor recycling cell-ECM interactions, and cell migration. | CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration.
Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, Shapiro LH., Free PMC Article | 07/4/2020 |
| The histological data revealed the progression of liver cancer. Immunohistochemical analysis showed the strong expression of CD133 in metastatic cancer. In contrast, the expression of CD13 in both primary and metastatic liver cancer was found to be very strong. | Aberrant expression of CD13 and stem cell markers in CD133-induced liver cancer in mice.
Wang Q, Chen N, Yu C, Wei Z, Li Z, Jin Z. | 03/7/2020 |
| we concluded that APN plays a significant role in the regulation of several sperm functions and early embryonic development. In addition, increased APN activity could potentially lead to several adverse consequences related to male fertility. | Elevated aminopeptidase N affects sperm motility and early embryo development.
Khatun A, Rahman MS, Ryu DY, Kwon WS, Pang MG., Free PMC Article | 10/14/2017 |
| These studies identified CD13 as a novel negative regulator of mast cell activation in vitro and in vivo. | CD13/aminopeptidase N is a negative regulator of mast cell activation.
Zotz JS, Wölbing F, Lassnig C, Kauffmann M, Schulte U, Kolb A, Whitelaw B, Müller M, Biedermann T, Huber M. | 08/19/2017 |
| 14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis. | The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage.
Nefla M, Sudre L, Denat G, Priam S, Andre-Leroux G, Berenbaum F, Jacques C., Free PMC Article | 06/4/2016 |
| Alanyl aminopeptidase expression is confined to mature zymogenic chief cells and its expression is lost en route to metaplasia. | Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells.
Moore BD, Jin RU, Osaki L, Romero-Gallo J, Noto J, Peek RM Jr, Mills JC., Free PMC Article | 04/16/2016 |
| CD13 negatively regulates TLR4 signaling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation. | CD13 restricts TLR4 endocytic signal transduction in inflammation.
Ghosh M, Subramani J, Rahman MM, Shapiro LH., Free PMC Article | 07/4/2015 |
| The impact of loss of CD13 on a model of ischemic skeletal muscle injury, was investigated. | CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury.
Rahman MM, Ghosh M, Subramani J, Fong GH, Carlson ME, Shapiro LH., Free PMC Article | 01/10/2015 |
| Molecular mechanisms regulating CD13-mediated adhesion. | Molecular mechanisms regulating CD13-mediated adhesion.
Ghosh M, Gerber C, Rahman MM, Vernier KM, Pereira FE, Subramani J, Caromile LA, Shapiro LH., Free PMC Article | 09/13/2014 |
| CD13 is essential for proper trafficking of the inflammatory cells necessary to prime and sustain the reparative response, thus promoting optimal post-infarction healing. | CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.
Pereira FE, Cronin C, Ghosh M, Zhou SY, Agosto M, Subramani J, Wang R, Shen JB, Schacke W, Liang B, Yang TH, McAulliffe B, Liang BT, Shapiro LH., Free PMC Article | 06/21/2014 |
| Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. | Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.
Subramani J, Ghosh M, Rahman MM, Caromile LA, Gerber C, Rezaul K, Han DK, Shapiro LH., Free PMC Article | 11/30/2013 |
| This indicates that Anpep plays a critical role in the proteolytic remodelling of mammary tissue during adult mammary development. | Mammary gland development is delayed in mice deficient for aminopeptidase N.
Kolb AF, Sorrell D, Lassnig C, Lillico S, Carlisle A, Neil C, Robinson C, Müller M, Whitelaw CB., Free PMC Article | 09/14/2013 |
| the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 and the neutral amino acid transporter B0AT1 | Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.
Fairweather SJ, Bröer A, O'Mara ML, Bröer S., Free PMC Article | 11/3/2012 |
| cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis | Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.
Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R., Free PMC Article | 03/31/2012 |
| expression of CD13 in normal and pathological human tissues | Enhanced expression of CD13 in vessels of inflammatory and neoplastic tissues.
Di Matteo P, Arrigoni GL, Alberici L, Corti A, Gallo-Stampino C, Traversari C, Doglioni C, Rizzardi GP., Free PMC Article | 04/9/2011 |
| Data show that the majority of chondrocyte-like cells are of bone marrow origin, whereas CD34(+)/CD13(+) myeloid precursors appear to infiltrate the plaque actively and transdifferentiate into chondrocyte-like cells in the progression of atherosclerosis. | Myeloid CD34+CD13+ precursor cells transdifferentiate into chondrocyte-like cells in atherosclerotic intimal calcification.
Doehring LC, Heeger C, Aherrahrou Z, Kaczmarek PM, Erdmann J, Schunkert H, Ehlers EM., Free PMC Article | 12/11/2010 |
| although CD13 is highly expressed on myeloid cells and is a reliable marker of the myeloid lineage of normal and leukemic cells, it is not a critical regulator of hematopoietic development, hemostasis, or myeloid cell function | CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse.
Winnicka B, O'Conor C, Schacke W, Vernier K, Grant CL, Fenteany FH, Pereira FE, Liang B, Kaur A, Zhao R, Montrose DC, Rosenberg DW, Aguila HL, Shapiro LH., Free PMC Article | 09/13/2010 |
| Results suggest that CD26 and CD13 play a role in T cell function in tissue-specific autoimmunity in the central nervous system. | Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
Biton A, Bank U, Täger M, Ansorge S, Reinhold D, Lendeckel U, Brocke S. | 01/21/2010 |
| CD13 expressed in microglia-derived exosomes is active in neuropeptide degradation and could have a distinct effect on local neuropeptide activity in the brain. | Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L. | 01/21/2010 |