| Functional involvement of endothelial lipase in hepatitis B virus infection. | Functional involvement of endothelial lipase in hepatitis B virus infection.
Shirasaki T, Murai K, Ishida A, Kuroki K, Kawaguchi K, Wang Y, Yamanaka S, Yasukawa R, Kawasaki N, Li YY, Shimakami T, Sumiyadorj A, Nio K, Sugimoto S, Orita N, Takayama H, Okada H, Thi Bich PD, Iwabuchi S, Hashimoto S, Ide M, Tabata N, Ito S, Matsushima K, Yanagawa H, Yamashita T, Kaneko S, Honda M., Free PMC Article | 09/20/2023 |
| Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain. | Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
Sugasini D, Yang P, Ng D, Khetarpal SA, Vitali C, Rader DJ, Subbaiah PV., Free PMC Article | 11/27/2021 |
| FoxA1, FoxA2, and LIPG control the uptake of extracellular lipids for breast cancer growth. | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.
Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ, Gomis RR., Free PMC Article | 08/27/2016 |
| inhibitory activity of AOE on pancreatic lipase enzyme was evaluated at concentrations from 60 to 1000 mug/mL. The AOE inhibited the pancreatic lipase with an IC50 = 588.5 mug/mL | Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract.
Padilla-Camberos E, Flores-Fernandez JM, Fernandez-Flores O, Gutierrez-Mercado Y, Carmona-de la Luz J, Sandoval-Salas F, Mendez-Carreto C, Allen K., Free PMC Article | 03/12/2016 |
| Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids. | Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ., Free PMC Article | 01/10/2015 |
| Furin has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase in hepatocytes | Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG., Free PMC Article | 12/21/2013 |
| The role of EL in HDL-associated S1P effects provides new insights into EL action, the responses seen through EL and HDL interaction, and S1P signaling. | Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.
Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J., Free PMC Article | 09/28/2013 |
| Endothelial lipase may act as an alternative candidate to provide fatty acids to the heart and regulate cardiac function. | Endothelial lipase modulates pressure overload-induced heart failure through alternative pathway for fatty acid uptake.
Nakajima H, Ishida T, Satomi-Kobayashi S, Mori K, Hara T, Sasaki N, Yasuda T, Toh R, Tanaka H, Kawai H, Hirata K. | 07/6/2013 |
| Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. | Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Escolà-Gil JC, Chen X, Julve J, Quesada H, Santos D, Metso J, Tous M, Jauhiainen M, Blanco-Vaca F. | 06/15/2013 |
| Endothelial lipase supplies cells with free fatty acids and HDL-derived lysophosphatidylcholine and lysophosphatidylethanolamine species resulting in increased cellular triglycerides and phosphatidylcholine (PC) content and decreased PC synthesis. | Impact of endothelial lipase on cellular lipid composition.
Riederer M, Köfeler H, Lechleitner M, Tritscher M, Frank S., Free PMC Article | 06/15/2013 |
| EL expression modulates vascular remodeling as well as plasma HDL-C levels | Expression of endothelial lipase correlates with the size of neointima in a murine model of vascular remodeling.
Sun L, Ishida T, Okada T, Yasuda T, Hara T, Toh R, Shinohara M, Yamashita T, Rikitake Y, Hirata K. | 06/1/2013 |
| Starvation regulates endothelial lipase expression via SREBP-2. | Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A.
Kivelä AM, Dijkstra MH, Heinonen SE, Gurzeler E, Jauhiainen S, Levonen AL, Ylä-Herttuala S. | 05/4/2013 |
| Endothelial lipase plays a role in thyroid and adipocyte biology in addition to its well-known role in endothelial function and HDL metabolism. | Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes.
Connelly MA, D'Andrea MR, Qi J, Dzordzorme KC, Damiano BP., Free PMC Article | 10/27/2012 |
| DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams. | Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
Hayashi Y, Ito Y, Yanagiba Y, Kamijima M, Naito H, Nakajima T. | 07/14/2012 |
| targeted disruption of EL increased HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions | Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo.
Hara T, Ishida T, Kojima Y, Tanaka H, Yasuda T, Shinohara M, Toh R, Hirata K., Free PMC Article | 06/25/2011 |
| Statins can reduce EL expression in vitro and in vivo via inhibition of RhoA activity. The inhibition of EL expression in the vessel wall may contribute to the anti-atherogenic effects of statins. | Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo.
Kojima Y, Ishida T, Sun L, Yasuda T, Toh R, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, Hirata K. | 10/23/2010 |
| The additive effect of hepatic lipase and EL on HDL metabolism but not macrophage reverse cholesterol transport in mice. | Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.
Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ., Free PMC Article | 09/20/2010 |
| Data show that endothelial lipase (EL) was upregulated in rat atherosclerosis and taht lipopolysaccharide stimulates EL expression in vitro through NFkappaB activation. | Regulated expression of endothelial lipase in atherosclerosis.
Wu X, Huang H, Tang F, Le K, Xu S, Liu P. | 07/12/2010 |
| EL can modulate plasma HDL-CHOL levels through both its lipolytic and ligand-binding functions in hypertriglyceridemic mice, while lipolytic activity appears to be the main determinant for its effects on HDL metabolism in normolipidemic mice. | Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia.
Tanaka H, Ishida T, Johnston TP, Yasuda T, Ueyama T, Kojima Y, Kundu RK, Quertermous T, Ishikawa Y, Hirata K. | 01/21/2010 |
| Endothelial lipase is a novel modulator of the progression of allergic asthma. | Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration.
Otera H, Ishida T, Nishiuma T, Kobayashi K, Kotani Y, Yasuda T, Kundu RK, Quertermous T, Hirata K, Nishimura Y. | 01/21/2010 |
| SR-BI-mediated selective uptake of HDL cholesteryl ester is essential for the remodeling of large alpha-migrating HDL particles by EL. | Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase.
Nijstad N, Wiersma H, Gautier T, van der Giet M, Maugeais C, Tietge UJ. | 01/21/2010 |
| after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. | The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.
Mayer G, Hamelin J, Asselin MC, Pasquato A, Marcinkiewicz E, Tang M, Tabibzadeh S, Seidah NG. | 01/21/2010 |
| EL expression is upregulated by lipopolysaccharide via TLR4 and promotes the uptake of native LDL by macrophages | Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages.
Yasuda T, Hirata K, Ishida T, Kojima Y, Tanaka H, Okada T, Quertermous T, Yokoyama M. | 01/21/2010 |
| endothelial lipase has a role in regulating HDL cholesterol levels | Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo.
Jin W, Millar JS, Broedl U, Glick JM, Rader DJ., Free PMC Article | 01/21/2010 |
| endothelial lipase has a role in regulating HDL levels | Endothelial lipase is a major determinant of HDL level.
Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD, Quertermous T., Free PMC Article | 01/21/2010 |