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    SLC30A8 solute carrier family 30 member 8 [ Homo sapiens (human) ]

    Gene ID: 169026, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Electrophysiological Characterization of Inducible Pluripotent Stem Cell-Derived Human beta-Like Cells and an SLC30A8 Disease Model.

    Electrophysiological Characterization of Inducible Pluripotent Stem Cell-Derived Human β-Like Cells and an SLC30A8 Disease Model.
    Jaffredo M, Krentz NAJ, Champon B, Duff CE, Nawaz S, Beer N, Honore C, Clark A, Rorsman P, Lang J, Gloyn AL, Raoux M, Hastoy B.,

    07/24/2024
    Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic beta-cell survival and function.

    Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function.
    Hu M, Kim I, Morán I, Peng W, Sun O, Bonnefond A, Khamis A, Bonàs-Guarch S, Froguel P, Rutter GA.,

    05/17/2024
    Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis.

    Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis.
    Xie W, Zhang L, Wang J, Wang Y.

    11/28/2023
    Zinc intake, SLC30A8 rs3802177 polymorphism, and colorectal cancer risk in a Korean population: a case-control study.

    Zinc intake, SLC30A8 rs3802177 polymorphism, and colorectal cancer risk in a Korean population: a case-control study.
    Nguyen LTD, Gunathilake M, Lee J, Oh JH, Chang HJ, Sohn DK, Shin A, Kim J.

    11/20/2023
    Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese population.

    Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese population.
    Zeng Q, Tan B, Han F, Huang X, Huang J, Wei Y, Guo R., Free PMC Article

    06/21/2023
    ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition.

    ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition.
    Sui L, Du Q, Romer A, Su Q, Chabosseau PL, Xin Y, Kim J, Kleiner S, Rutter GA, Egli D., Free PMC Article

    04/12/2023
    Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults.

    Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults.
    Yang Z, Wang YE, Kirschke CP, Stephensen CB, Newman JW, Keim NL, Cai Y, Huang L.

    03/28/2023
    Relationship Between the Single Nucleotide Polymorphism rs11558471 in the SLC30A8/ZnT8 Gene and Cardiometabolic Markers in Postmenopausal Women.

    Relationship Between the Single Nucleotide Polymorphism rs11558471 in the SLC30A8/ZnT8 Gene and Cardiometabolic Markers in Postmenopausal Women.
    da Costa SKS, Almeida JA, Pires LV, Brandão-Lima PN, Rogero MM, Mendes-Netto RS.

    03/23/2023
    Integrated analysis of probability of type 2 diabetes mellitus with polymorphisms and methylation of SLC30A8 gene: a nested case-control study.

    Integrated analysis of probability of type 2 diabetes mellitus with polymorphisms and methylation of SLC30A8 gene: a nested case-control study.
    Hu F, Zhang Y, Qin P, Zhao Y, Liu D, Zhou Q, Tian G, Li Q, Guo C, Wu X, Qie R, Huang S, Han M, Li Y, Hu D, Zhang M.

    10/29/2022
    Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.

    Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.
    Chen G, Shriner D, Zhang J, Zhou J, Adikaram P, Doumatey AP, Bentley AR, Adeyemo A, Rotimi CN., Free PMC Article

    06/11/2022
    Autoantibodies to Zinc Transporter 8 and SLC30A8 Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa.

    Autoantibodies to Zinc Transporter 8 and SLC30A8 Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa.
    Fakhfakh R, Kmiha S, Tahri S, Feki S, Zouidi F, Abida O, Hachicha M, Kammoun T, Masmoudi H., Free PMC Article

    06/11/2022
    The common rs13266634 C > T variant in SLC30A8 contributes to the heterogeneity of phenotype and clinical features of both type 1 and type 2 diabetic subtypes.

    The common rs13266634 C > T variant in SLC30A8 contributes to the heterogeneity of phenotype and clinical features of both type 1 and type 2 diabetic subtypes.
    Xu K, Lv H, Zhang J, Chen H, He Y, Shen M, Qian Y, Jiang H, Dai H, Zheng S, Yang T, Fu Q.

    03/19/2022
    Pancreatic beta cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis.

    Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis.
    Xu J, Wijesekara N, Regeenes R, Rijjal DA, Piro AL, Song Y, Wu A, Bhattacharjee A, Liu Y, Marzban L, Rocheleau JV, Fraser PE, Dai FF, Hu C, Wheeler MB., Free PMC Article

    02/19/2022
    Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8.

    Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8.
    Kawasaki E, Oikawa Y, Okada A, Kanatsuna N, Kawamura T, Kikuchi T, Terasaki J, Miura J, Itoh Y, Hanafusa T., Free PMC Article

    02/5/2022
    Evaluation of the Diagnostic and Predictive Value of Glutamic Acid Decarboxylase, Zinc Transporter 8 Serum Levels in Alzheimer's Disease.

    Evaluation of the Diagnostic and Predictive Value of Glutamic Acid Decarboxylase, Zinc Transporter 8 Serum Levels in Alzheimer's Disease.
    Sadrirad S, Samadi N, Nikanfar M, Moayed ZB, Laghousi D, Hasanzade Z, Maroufi NF, Nourazarian A.

    01/29/2022
    Loss of Znt8 function in diabetes mellitus: risk or benefit?

    Loss of Znt8 function in diabetes mellitus: risk or benefit?
    Barragán-Álvarez CP, Padilla-Camberos E, Díaz NF, Cota-Coronado A, Hernández-Jiménez C, Bravo-Reyna CC, Díaz-Martínez NE.

    07/31/2021
    Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations.

    Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations.
    Sala D, Giachetti A, Rosato A., Free PMC Article

    07/17/2021
    Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes.

    Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes.
    Ahmadi M, Mahrooz A, Abediankenari S, Hayati Roodbari N.

    07/3/2021
    RNA interference-mediated knockdown of the Drosophila ortholog of SLC30A8 in insulin-producing cells, a model for mammalian beta cells, conferred reduced insulin output.

    Discovering human diabetes-risk gene function with genetics and physiological assays.
    Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK., Free PMC Article

    06/14/2021
    Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions.

    Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions.
    Catapano MC, Parsons DS, Kotuniak R, Mladěnka P, Bal W, Maret W., Free PMC Article

    05/1/2021
    Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease.

    Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease.
    Zhang X, Guan T, Yang B, Gu HF, Chi Z., Free PMC Article

    03/27/2021
    ZnT8 in T2D: a novel therapeutic target for maintaining insulin secretion capacity.

    ZnT8 in T2D: a novel therapeutic target for maintaining insulin secretion capacity.
    Zhang Y, Jian W, He L, Wu J.

    02/6/2021
    SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population.

    SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population.
    Mashal S, Khanfar M, Al-Khalayfa S, Srour L, Mustafa L, Hakooz NM, Zayed AA, Khader YS, Azab B.

    02/2/2021
    C-Terminal Domain of the Human Zinc Transporter hZnT8 Is Structurally Indistinguishable from Its Disease Risk Variant (R325W).

    C-Terminal Domain of the Human Zinc Transporter hZnT8 Is Structurally Indistinguishable from Its Disease Risk Variant (R325W).
    Ullah R, Shehzad A, Shah MA, March M, Ismat F, Iqbal M, Onesti S, Rahman M, McPherson MJ., Free PMC Article

    11/21/2020
    review of zinc transporter 8 autoimmunity and genetic variants role in type 1 diabetes [review]

    What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?
    Williams CL, Long AE., Free PMC Article

    07/11/2020
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