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    Sp7 Sp7 transcription factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 170574, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Apolipoprotein E deficiency attenuated osteogenesis via down-regulating osterix.

    Apolipoprotein E deficiency attenuated osteogenesis via down-regulating osterix.
    Qi Q, Xu Y, Sun H, Zhou J, Li L, Pan X, Wang J, Cao W, Sun Y, Wang L.

    09/20/2023
    The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation.

    The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation.
    Chen J, Liu D, Chen B, Yang Y, Zhu H, Li D, Liu K, Zhu L, Liu H, Li M, Zhang X, Li X.

    08/9/2023
    Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.

    Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
    Hu G, Shi X, Qu X, Han C, Hu A, Jia Z, Yang J, Liu H, Wu Y., Free PMC Article

    03/17/2023
    Epigenetic Repression of RUNX2 and OSX Promoters Controls the Nonmineralized State of the Periodontal Ligament.

    Epigenetic Repression of RUNX2 and OSX Promoters Controls the Nonmineralized State of the Periodontal Ligament.
    Gopinathan G, Luan X, Diekwisch TGH., Free PMC Article

    02/14/2023
    Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading.

    Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading.
    Moriishi T, Ito T, Fukuyama R, Qin X, Komori H, Kaneko H, Matsuo Y, Yoshida N, Komori T., Free PMC Article

    04/16/2022
    A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder.

    A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder.
    Lui JC, Raimann A, Hojo H, Dong L, Roschger P, Kikani B, Wintergerst U, Fratzl-Zelman N, Jee YH, Haeusler G, Baron J., Free PMC Article

    02/26/2022
    Inflammatory osteoclasts-derived exosomes promote bone formation by selectively transferring lncRNA LIOCE into osteoblasts to interact with and stabilize Osterix.

    Inflammatory osteoclasts-derived exosomes promote bone formation by selectively transferring lncRNA LIOCE into osteoblasts to interact with and stabilize Osterix.
    Ren L, Zeng F, Deng J, Bai Y, Chen K, Chen L, Sun L.

    02/19/2022
    Skeletal Deformities in Osterix-Cre;Tgfbr2(f/f) Mice May Cause Postnatal Death.

    Skeletal Deformities in Osterix-Cre;Tgfbr2(f/f) Mice May Cause Postnatal Death.
    Corps K, Stanwick M, Rectenwald J, Kruggel A, Peters SB., Free PMC Article

    02/5/2022
    C-C chemokine receptor type 6 modulates the biological function of osteoblastogenesis by altering the expression levels of Osterix and OPG/RANKL.

    C-C chemokine receptor type 6 modulates the biological function of osteoblastogenesis by altering the expression levels of Osterix and OPG/RANKL.
    Li L, Zhou J, Xu Y, Huang Z, Zhang N, Qiu X, Wang L.

    01/22/2022
    Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.

    Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.
    Nakamura E, Hata K, Takahata Y, Kurosaka H, Abe M, Abe T, Kihara M, Komori T, Kobayashi S, Murakami T, Inubushi T, Yamashiro T, Yamamoto S, Akiyama H, Kawaguchi M, Sakata N, Nishimura R., Free PMC Article

    12/25/2021
    Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.

    Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
    Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN., Free PMC Article

    12/25/2021
    Constitutive activation of NF-kappaB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.

    Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
    Davis JL, Thaler R, Cox L, Ricci B, Zannit HM, Wan F, Faccio R, Dudakovic A, van Wijnen AJ, Veis DJ., Free PMC Article

    11/13/2021
    Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations.

    Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations.
    Patra D, Kim J, Zhang Q, Tycksen E, Sandell LJ., Free PMC Article

    08/28/2021
    SHP2 regulates the development of intestinal epithelium by modifying OSTERIX(+) crypt stem cell self-renewal and proliferation.

    SHP2 regulates the development of intestinal epithelium by modifying OSTERIX(+) crypt stem cell self-renewal and proliferation.
    Wang L, Moore DC, Huang J, Wang Y, Zhao H, D-H Yue J, Jackson CL, Quesenberry PJ, Cao W, Yang W.

    06/19/2021
    Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation.

    Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation.
    Hoshikawa S, Shimizu K, Watahiki A, Chiba M, Saito K, Wei W, Fukumoto S, Inuzuka H.

    05/1/2021
    Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3E1 cells via an autocrine mechanism.

    Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism.
    Zhang B, Zhang X, Xiao J, Zhou X, Chen Y, Gao C., Free PMC Article

    05/1/2021
    miR27a3p negatively regulates osteogenic differentiation of MC3T3E1 preosteoblasts by targeting osterix.

    miR‑27a‑3p negatively regulates osteogenic differentiation of MC3T3‑E1 preosteoblasts by targeting osterix.
    Xu Y, Li D, Zhu Z, Li L, Jin Y, Ma C, Zhang W., Free PMC Article

    04/24/2021
    Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway.

    Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway.
    Qiu WX, Ma XL, Lin X, Zhao F, Li DJ, Chen ZH, Zhang KW, Zhang R, Wang P, Xiao YY, Miao ZP, Dang K, Wu XY, Qian AR., Free PMC Article

    03/20/2021
    Hdac9 inhibits medial artery calcification through down-regulation of Osterix.

    Hdac9 inhibits medial artery calcification through down-regulation of Osterix.
    He P, Yu H, Jiang L, Chen Z, Wang S, Macrae VE, Fu X, Zhu D.

    03/6/2021
    Schisandrin B regulates MC3T3-E1 subclone 14 cells proliferation and differentiation through BMP2-SMADs-RUNX2-SP7 signaling axis.

    Schisandrin B regulates MC3T3-E1 subclone 14 cells proliferation and differentiation through BMP2-SMADs-RUNX2-SP7 signaling axis.
    Wang X, Liao X, Zhang Y, Wei L, Pang Y., Free PMC Article

    02/27/2021
    The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts.

    The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts.
    Sun Y, Cai M, Zhong J, Yang L, Xiao J, Jin F, Xue H, Liu X, Liu H, Zhang Y, Jiang D, Hong A, Ji X, Wang Z, Zhang G, Wang X.

    01/9/2021
    Loss of interleukin-10 exacerbates early Type-1 diabetes-induced bone loss.

    Loss of interleukin-10 exacerbates early Type-1 diabetes-induced bone loss.
    Rios-Arce ND, Dagenais A, Feenstra D, Coughlin B, Kang HJ, Mohr S, McCabe LR, Parameswaran N., Free PMC Article

    12/19/2020
    Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.

    Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.
    Silva MJ, Holguin N., Free PMC Article

    10/3/2020
    adipoq, kitl and osx1 may have a role with regulation of hematopoietic stem and progenitor cells and myeloid progenitors

    Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
    Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB., Free PMC Article

    08/1/2020
    CCN3 promotes the expression of Runx2 and osterix in osteoblasts by inhibiting miR-608 expression via the FAK and Akt signaling pathways

    CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K/Akt Signaling in Osteoblasts.
    Chen PC, Liu JF, Fong YC, Huang YL, Chao CC, Tang CH., Free PMC Article

    12/21/2019
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