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    Nphs2 NPHS2 stomatin family member, podocin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170672, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The effects of sildenafil citrate on urinary podocin and nephrin mRNA expression in an L-NAME model of pre-eclampsia.

    The effects of sildenafil citrate on urinary podocin and nephrin mRNA expression in an L-NAME model of pre-eclampsia.
    Baijnath S, Murugesan S, Mackraj I, Gathiram P, Moodley J.

    02/18/2017
    These findings suggest that candesartan can prevent cisplatin-induced testicular damage by regulating expression patterns of the nephrin-podocin complex in the testes.

    Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin.
    Enatsu N, Miyake H, Chiba K, Fujisawa M., Free PMC Article

    08/20/2016
    translocation of podocin by endocytosis could be a key traffic event of critical podocyte injury and that the podocin gap could indicate the prognosis of IgA nephropathy.

    Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor-prognosis patients with IgA nephropathy.
    Fukuda H, Hidaka T, Takagi-Akiba M, Ichimura K, Oliva Trejo JA, Sasaki Y, Wang J, Sakai T, Asanuma K, Tomino Y., Free PMC Article

    01/30/2016
    Resveratrol alleviated dyslipidemia and renal damage induced by high-fat diet also reduced TNF-alpha and MCP-1 levels, and reduced expressions of nephrin and podocin.

    Resveratrol increases nephrin and podocin expression and alleviates renal damage in rats fed a high-fat diet.
    Pan QR, Ren YL, Zhu JJ, Hu YJ, Zheng JS, Fan H, Xu Y, Wang G, Liu WX., Free PMC Article

    02/28/2015
    ATP evokes activation of TRPC6 channels in podocytes through P2Y receptors, podocin, and generation of reactive oxygen species.

    ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species.
    Roshanravan H, Dryer SE.

    06/21/2014
    Huaiqihuang Granule can up-regulate the expressions of nephrin and podocin in renal tissues of rats with adriamycin-induced nephrosis.

    [Effects of Chinese herbal medicine Huaiqihuang Granule on nephrin and podocin expressions in renal tissues of rats with adriamycin-induced nephrosis].
    Sun W, Zhu Z, Yu J, Wang YH, Xiong M, Gao X, Zhao ZH, Liu XG.

    03/17/2012
    Podocin may serve as scaffold that links tight junction proteins to actin cytoskeleton in nephrotic foot processes.

    Podocin participates in the assembly of tight junctions between foot processes in nephrotic podocytes.
    Shono A, Tsukaguchi H, Yaoita E, Nameta M, Kurihara H, Qin XS, Yamamoto T, Doi T.

    01/21/2010
    variants in NPHS2 promoter is associated with nephrotic syndrome

    Rare functional variants of podocin (NPHS2) promoter in patients with nephrotic syndrome.
    Oleggini R, Bertelli R, Di Donato A, Di Duca M, Caridi G, Sanna-Cherchi S, Scolari F, Murer L, Allegri L, Coppo R, Emma F, Camussi G, Perfumo F, Ghiggeri GM., Free PMC Article

    01/21/2010
    podocin is one of critical components of slit diaphragm for maintaining barrier function of glomerular capillary wall

    Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli.
    Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F.

    01/21/2010
    Fyn phosphorylates the cytoplasmic domain of nephrin on tyrosine, leading to enhanced association with podocin and downstream signaling of nephrin.

    SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin.
    Li H, Lemay S, Aoudjit L, Kawachi H, Takano T.

    01/21/2010
    Downregulation of podocin in induced Minimal change-like nephropathy.

    Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.
    Lai KW, Wei CL, Tan LK, Tan PH, Chiang GS, Lee CG, Jordan SC, Yap HK.

    01/21/2010
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