| H4R expression increased in a rat model of lipopolysaccharide (LPS)-induced CNS inflammation. Knockdown of H4R in microglia HAPI cells enhanced the production of cytokines following LPS stimulation. Co-immunoprecipitation experiments further revealed an interaction between H4R and tumor necrosis factor receptor-associated factor 6 (TRAF6) in microglia, which was verified both in vivo and in vitro. | H4 Receptor Inhibits Lipopolysaccharide-induced NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor-Associated Factor 6.
Shan Y, Gao Y, Zhang L, Ma L, Shi Y, Liu X. | 03/23/2019 |
| the present study found that blocking H4R exerted a significant anti-inflammatory effect at 2 h after Lipopolysaccharide injection and inhibited pro-inflammatory Tumor Necrosis Factor-alpha- and NF-kappaB expression | Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation.
Ahmad SF, Ansari MA, Zoheir KM, Bakheet SA, Korashy HM, Nadeem A, Ashour AE, Attia SM. | 02/29/2016 |
| Data indicate that positive histamine H4 receptor (HRH4) immunostaining was detected in Leydig cells of all testicular sections. | H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.
Abiuso AM, Berensztein E, Pagotto RM, Pereyra EN, Medina V, Martinel Lamas DJ, Besio Moreno M, Pignataro OP, Mondillo C. | 01/31/2015 |
| H3 and H4 receptors in endothelial cells are potentially important for regulation of blood-brain barrier permeability, including trafficking of immunocompetent cells | Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.
Karlstedt K, Jin C, Panula P., Free PMC Article | 09/6/2014 |
| The H4 receptor is expressed in the kidney mainly by resident renal cells of the loop of Henle and is significantly overexpressed in diabetic animals, suggesting a possible role in the pathogenesis of diabetes-associated renal disease | Overexpression of histamine H₄ receptors in the kidney of diabetic rat.
Rosa AC, Grange C, Pini A, Katebe MA, Benetti E, Collino M, Miglio G, Bani D, Camussi G, Chazot PL, Fantozzi R. | 08/31/2013 |
| DAO secretion may contribute to the catabolism of histamine released during fat absorption and this is probably mediated through the histamine H(4) receptor. | Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release.
Ji Y, Sakata Y, Li X, Zhang C, Yang Q, Xu M, Wollin A, Langhans W, Tso P., Free PMC Article | 06/22/2013 |
| Histamine inhibits lipopolysaccharide-induced interleukin (IL)-1beta release in hippocampal organotypic slice cultures. | Histamine modulates microglia function.
Ferreira R, Santos T, Gonçalves J, Baltazar G, Ferreira L, Agasse F, Bernardino L., Free PMC Article | 06/15/2013 |
| H4 receptors are the primary receptors involved in effective histaminergic regulation of the excitability of vestibular primary neurons. | Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
Desmadryl G, Gaboyard-Niay S, Brugeaud A, Travo C, Broussy A, Saleur A, Dyhrfjeld-Johnsen J, Wersinger E, Chabbert C., Free PMC Article | 02/16/2013 |
| analysis of fragment optimization and analysis of binding kinetics for ligand based design of novel histamine H receptor antagonists | Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Smits RA, Lim HD, van der Meer T, Kuhne S, Bessembinder K, Zuiderveld OP, Wijtmans M, de Esch IJ, Leurs R. | 08/4/2012 |
| The present data suggest for the first time a possible ulcerogenic role mediated by histamine H4 receptors in the rat gastric mucosa | Selective histamine H₃ and H₄ receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach.
Coruzzi G, Adami M, Pozzoli C, de Esch IJ, Smits R, Leurs R. | 02/11/2012 |
| Histamine H4 receptor is closely related with allergic rhinitis and is important in the pathogenesis of allergic rhinitis. | [Effect of histamine H4 receptor and its antagonist on allergic rhinitis in rats].
Yan ZQ, Zhang RX, Yu SQ, Wen W, Hong JK, Zhang J, Shao XL, Gao SH. | 02/5/2011 |
| Results do not suggest a role for histamine H4 receptors in the control of intestinal neurotransmission in the rat. | Effect of histamine H4 receptor ligands on cholinergic neurotransmission of the rat duodenum.
Pozzoli C, Adami M, Smits RA, Coruzzi G. | 01/21/2010 |
| Histamine H4 receptors are functionally expressed on neurons, which has major implications for the therapeutic potential of these receptors in neurology and psychiatry. | The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
Connelly WM, Shenton FC, Lethbridge N, Leurs R, Waldvogel HJ, Faull RL, Lees G, Chazot PL., Free PMC Article | 01/21/2010 |
| H(4) mRNA was detected in cortex, cerebellum, brainstem, amygdala, thalamus & striatum; low levels were detected in hypothalamus, & none was detected in the hippocampus; strong expression of H(4) mRNA was detected in dorsal root ganglion & spinal cord | Localization of histamine H4 receptors in the central nervous system of human and rat.
Strakhova MI, Nikkel AL, Manelli AM, Hsieh GC, Esbenshade TA, Brioni JD, Bitner RS. | 01/21/2010 |
| analysis of how quinazolines can act as histamine H4 receptor inverse agonists | Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
Smits RA, de Esch IJ, Zuiderveld OP, Broeker J, Sansuk K, Guaita E, Coruzzi G, Adami M, Haaksma E, Leurs R. | 01/21/2010 |
| Data show that histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa. | Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa.
Morini G, Becchi G, Shenton FC, Chazot PL, Grandi D. | 01/21/2010 |