| Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of beta-thalassemia. | Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia.
Han G, Cao C, Yang X, Zhao GW, Hu XJ, Yu DL, Yang RF, Yang K, Zhang YY, Wang WT, Liu XZ, Xu P, Liu XH, Chen P, Xue Z, Liu DP, Lv X., Free PMC Article | 03/12/2022 |
| eNOS reduced AHSP-bound alpha-globin approximately 6-fold faster than did the major erythrocyte hemoglobin reductases (cytochrome B5 reductase plus cytochrome B5). Our data support a model whereby redox-sensitive shuttling of EC alpha-globin between AHSP and eNOS regulates EC NO degradation and vascular tone. | Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility.
Lechauve C, Butcher JT, Freiwan A, Biwer LA, Keith JM, Good ME, Ackerman H, Tillman HS, Kiger L, Isakson BE, Weiss MJ., Free PMC Article | 09/14/2019 |
| role of alpha-hemoglobin stabilizing protein in hemoglobin assembly | Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ., Free PMC Article | 09/22/2012 |
| Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice. | Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia.
Nasimuzzaman M, Khandros E, Wang X, Kong Y, Zhao H, Weiss D, Rivella S, Weiss MJ, Persons DA., Free PMC Article | 10/23/2010 |
| The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported. | Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL.
Otsuka Y, Ito D, Katsuoka K, Arashiki N, Komatsu T, Inaba M. | 01/21/2010 |
| AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly | An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.
Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, Zhou S, Choi JK, Gell D, Mackay JP, Gow AJ, Weiss MJ., Free PMC Article | 01/21/2010 |
| activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism | Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.
van Eyll JM, Pierreux CE, Lemaigre FP, Rousseau GG. | 01/21/2010 |
| developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription | Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.
Shyu YC, Lee TL, Wen SC, Chen H, Hsiao WY, Chen X, Hwang J, Shen CK., Free PMC Article | 01/21/2010 |
| An abundant erythroid protein that stabilizes free alpha-haemoglobin. | An abundant erythroid protein that stabilizes free alpha-haemoglobin.
Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ. | 01/21/2010 |
| These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes. | Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.
Pilon AM, Nilson DG, Zhou D, Sangerman J, Townes TM, Bodine DM, Gallagher PG., Free PMC Article | 01/21/2010 |
| Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia. | Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.
Kong Y, Zhou S, Kihm AJ, Katein AM, Yu X, Gell DA, Mackay JP, Adachi K, Foster-Brown L, Louden CS, Gow AJ, Weiss MJ., Free PMC Article | 01/21/2010 |