| Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1. | Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
Li T, Fei J, Yu H, Wang X, Li D, Yin Z. | 06/15/2023 |
| Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier. | Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier.
Kanda H, Noguchi K, Dai Y., Free PMC Article | 01/21/2023 |
| The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders. | The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders.
Ulkumen B, Artunc Ulkumen B, Batir MB, Cam S, Vatansever S. | 04/9/2022 |
| PKC- and PKA-dependent phosphorylation modulates TREK-1 function in naive and neuropathic rats. | PKC- and PKA-dependent phosphorylation modulates TREK-1 function in naïve and neuropathic rats.
García G, Méndez-Reséndiz KA, Oviedo N, Murbartián J. | 08/28/2021 |
| The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2. | The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2.
Li R, Zhao K, Ruan Q, Meng C, Yin F., Free PMC Article | 07/3/2021 |
| we show that TREK-1 and TRAAK are clustered at nodes of Ranvier of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas | TREK-1 and TRAAK Are Principal K(+) Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
Kanda H, Ling J, Tonomura S, Noguchi K, Matalon S, Gu JG., Free PMC Article | 03/28/2020 |
| The authors show that TREK-1 activity is involved in the bupivacaine (BPV)-induced cytotoxicity and the antagonistic effect of lipid emulsion (LE) in H9c2 rat cardiomyoblasts and suggest that TREK-1 could be a target for action of BPV and LE. | Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion.
Yang JH, Siregar AS, Kim EJ, Nyiramana MM, Shin EJ, Han J, Sohn JT, Kim JW, Kang D., Free PMC Article | 01/4/2020 |
| that miR-183-5P participated in the regulation of chronic constriction sciatic nerve injury-induced neuropathic pain through inhibiting the expression of TREK-1 | MiR-183-5p Alleviates Chronic Constriction Injury-Induced Neuropathic Pain Through Inhibition of TREK-1.
Shi DN, Yuan YT, Ye D, Kang LM, Wen J, Chen HP. | 04/20/2019 |
| strong immunoreactivity of TRAAK, TREK-1 and TREK-2 channels was present mainly in small-sized dorsal root ganglion (DRG) neurons of rats. | Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats.
Viatchenko-Karpinski V, Ling J, Gu JG., Free PMC Article | 10/27/2018 |
| TREK-1 channel was upregulated in the DRG of DO rats after chronic partial bladder outlet obstruction, which might suppress neuronal excitability and play a protective role in bladder overactivity in PBOO. | Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction.
Zhang J, Cao M, Chen Y, Wan Z, Wang H, Lin H, Liang W, Liang Y., Free PMC Article | 09/1/2018 |
| During sympathetic stimulation, inhibition of TREK-1 channels via PKA is expected to prolong the action potential primarily in subendocardial myocytes | The potassium current carried by TREK-1 channels in rat cardiac ventricular muscle.
Bodnár M, Schlichthörl G, Daut J. | 02/20/2016 |
| The expressions of TREK-1 mRNA and protein were significantly increased in hippocampus and Prefrontal cortex in Poststroke Depression rats | The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression.
Lin DH, Zhang XR, Ye DQ, Xi GJ, Hui JJ, Liu SS, Li LJ, Zhang ZJ., Free PMC Article | 02/6/2016 |
| We conclude that Trek1 is critical to maintain the nasal epithelial barrier function. | Trek1 contributes to maintaining nasal epithelial barrier integrity.
Jiang J, Liu JQ, Li J, Li M, Chen HB, Yan H, Mo LH, Qiu SQ, Liu ZG, Yang PC., Free PMC Article | 12/5/2015 |
| TREK-1 plays an important role in neonatal rat heart development and downregulation of TREK-1 may provide protection against ischemic injury. | Functional study of TREK-1 potassium channels during rat heart development and cardiac ischemia using RNAi techniques.
Yang X, Guo P, Li J, Wang W, Xu S, Wang L, Wang X. | 04/4/2015 |
| results suggest that the TREK-1e splice variant may interfere with the vesicular traffic of full-length TREK-1 channels from the ER to the plasma membrane. | A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.
Rinné S, Renigunta V, Schlichthörl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Müller R. | 02/28/2015 |
| Electrophysiology and pharmacology of tandem domain potassium channel TREK-1 related BDNF synthesis in rat astrocytes | Electrophysiology and pharmacology of tandem domain potassium channel TREK-1 related BDNF synthesis in rat astrocytes.
Lu L, Wang W, Peng Y, Li J, Wang L, Wang X. | 11/29/2014 |
| Down-regulation of TREK-1 in astrocytes contributed to the proliferation of astrocytes. | Small RNA interference-mediated gene silencing of TREK-1 potassium channel in cultured astrocytes.
Wu X, Tang R, Liu Y, Song J, Yu Z, Wang W, Xie M. | 09/13/2014 |
| Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning. | Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning.
Tong L, Cai M, Huang Y, Zhang H, Su B, Li Z, Dong H., Free PMC Article | 08/16/2014 |
| in hypertrophic rats, TREK-1 protein expression in endocardium was specifically increased and the ratio of TREK-1 channel current in cardiac outward currents was also enhanced. | An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy.
Wang W, Zhang M, Li P, Yuan H, Feng N, Peng Y, Wang L, Wang X. | 11/16/2013 |
| TREK-1 was up-regulated after hypoxia. Suppression of TREK-1 inhibited the glutamate clearance capability, enhanced the inflammatory secretion of astrocytes derived s100beta & led to increased neuronal apoptosis after ischemic insult. | Involvement of TREK-1 activity in astrocyte function and neuroprotection under simulated ischemia conditions.
Wu X, Liu Y, Chen X, Sun Q, Tang R, Wang W, Yu Z, Xie M. | 07/27/2013 |
| We find that TREK1, typically considered to be a leak channel, contributes to the hippocampal GABA(B) response. | Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling.
Sandoz G, Levitz J, Kramer RH, Isacoff EY., Free PMC Article | 09/15/2012 |
| TREK-1 was broadly expressed on astrocytes & neurons in the cortex & CA1 & cultured cells. After middle cerebral artery occlusion, expression increased after reperfusion during reactive astrogliosis. | Changes in lipid-sensitive two-pore domain potassium channel TREK-1 expression and its involvement in astrogliosis following cerebral ischemia in rats.
Wang M, Song J, Xiao W, Yang L, Yuan J, Wang W, Yu Z, Xie M. | 09/15/2012 |
| TREK-1 may participate in pathophysiologic alteration and electrical remodelling of left ventricular myocardium after MI | Regional differential expression of TREK-1 at left ventricle in myocardial infarction.
Zhao LN, Fu L, Gao QP, Xie RS, Cao JX. | 01/21/2012 |
| These results demonstrate that the primary activation mechanisms in TREK-1 reside close to, or within the selectivity filter and do not involve gating at the cytoplasmic bundle crossing. | The pore structure and gating mechanism of K2P channels.
Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T., Free PMC Article | 11/5/2011 |
| Mechanical stretching could up-regulate the expression of TREK-1 in the left ventricle. | Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle.
Zhao F, Dong L, Cheng L, Zeng Q, Su F. | 10/30/2010 |