| Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver. | Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
Gericke B, Wienböker I, Brandes G, Löscher W., Free PMC Article | 05/28/2022 |
| Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters. | Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Ganguly S, Finkelstein D, Shaw TI, Michalek RD, Zorn KM, Ekins S, Yasuda K, Fukuda Y, Schuetz JD, Mukherjee K, Schuetz EG., Free PMC Article | 11/22/2021 |
| Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats. | Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
Wang P, Chen Y, Zhang LM, Yuan SQ, Lu SA, Zhang YJ. | 07/3/2021 |
| Galactosemia caused the osmotic stress in lenses; it also markedly leads to the upregulations of aldose reductase, P-glycoprotein, and Clcn3 in lens epithelial cells, together resulting in obvious osmotic expansion in vitro and in vivo. | Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract.
Ji L, Cheng L, Yang Z., Free PMC Article | 09/29/2018 |
| Abcb1a is critical in maintaining blood-testis barrier integrity, while Abcb1b is crucial for junction reassembly at the blood-testis barrier. | Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat.
Su L, Cheng YC, Lee WM, Zhang M, Yang F, Zhao B, Han D, Liu Y, Hu D., Free PMC Article | 06/9/2018 |
| The placenta and maternal/fetal intestine, brain, kidneys and liver were sampled and analysed for Abcb1a, Abcb1b and Abcg2 expression. | Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs.
Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud F. | 10/22/2016 |
| Study demonstrates that P-GP expression and function may be altered in cerebral cortex, hippocampus, liver and kidney of rats under the vitamin A deficiency condition. | The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo.
Wang Y, Qin H, Zhang C, Huan F, Yan T, Zhang L., Free PMC Article | 10/8/2016 |
| The data indicate that Pgp and Bcrp do not play significant roles in drug distribution into peripheral nerve tissues in rats, while working in concert to regulate brain penetration. | Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.
Huang L, Li X, Roberts J, Janosky B, Lin MH. | 04/2/2016 |
| Both relative liver and kidney weights were higher in Mdr1a (and Mrp2)knockout animals. | Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP. | 02/8/2014 |
| Report drug metabolizing phenotype of Mdr1a knockout rats. | Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW. | 01/26/2013 |
| Results show that the presence of Mdr1a, Mdr1b (P-glycoprotein Pgp) and multidrug resistance-associated protein (MRP1) encoding genes in the olfactory mucosa of rat and mouse was confirmed by RT-PCR. | Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.
Molinas A, Sicard G, Jakob I., Free PMC Article | 09/22/2012 |
| In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed. | Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.
Thiebaud N, Menetrier F, Belloir C, Minn AL, Neiers F, Artur Y, Le Bon AM, Heydel JM. | 08/18/2012 |
| Findings show that P-glycoprotein (Abcb1a and Abcb1b) structurally interacted with focal adhesion kinase (FAK), creating the occludin/ZO-1/FAK/P-glycoprotein regulatory complex. | P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).
Su L, Mruk DD, Lui WY, Lee WM, Cheng CY., Free PMC Article | 04/14/2012 |
| Suggest that Lactobacilli or their soluble factors stimulate P-gp expression and function under normal and inflammatory conditions. | Upregulation of P-glycoprotein by probiotics in intestinal epithelial cells and in the dextran sulfate sodium model of colitis in mice.
Saksena S, Goyal S, Raheja G, Singh V, Akhtar M, Nazir TM, Alrefai WA, Gill RK, Dudeja PK., Free PMC Article | 08/20/2011 |
| Frequent seizures, especially status epilepticus resulted in overexpression of mdr1a and mdr1b mRNAs in the hippocampus. TPM could enhance the expression of mdr1a and mdr1b mRNAs in the hippocampus. | [Expression of multidrug resistance gene and topiramate affect expression of multidrug resistance gene in the hippocampus of spontaneous epileptic rats].
Jin RF, Sun RP, Xu XP. | 05/31/2010 |
| Under the conditions of the present study, alterations in Pgp are not critically involved in refractory status epilepticus. | Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Bankstahl JP, Löscher W. | 01/21/2010 |
| Results compare the relative amounts of ABCb1 (Pgp) and ABCc1 (Mrp1)at the blood-brain and blood-cerebrospinal fluid barriers, located respectively at the brain capillary endothelium and the choroid plexus epithelium. | Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces.
Gazzin S, Strazielle N, Schmitt C, Fevre-Montange M, Ostrow JD, Tiribelli C, Ghersi-Egea JF. | 01/21/2010 |
| Results suggest that nitrosative stress leads to the up-regulation of the mRNA for the transporter in the blood-brain barrier of streptozotocin-induced diabetic rats and, ultimately, to enhanced function, probably via a NFkappaB-dependent mechanism. | Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation.
Maeng HJ, Kim MH, Jin HE, Shin SM, Tsuruo T, Kim SG, Kim DD, Shim CK, Chung SJ. | 01/21/2010 |
| HAX-1 binds bile salt export protein (BSEP), cortactin, MDR1, and MDR2. HAX-1 and cortactin regulate BSEP abundance in the apical membrane of cells. | Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.
Ortiz DF, Moseley J, Calderon G, Swift AL, Li S, Arias IM. | 01/21/2010 |