| EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction in lipopolysaccharide-induced tubular epithelial cells. | EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction in lipopolysaccharide-induced tubular epithelial cells.
Hu W., Free PMC Article | 10/25/2024 |
| Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase. | Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase.
Wu Z, Zhang Y, Yang X, Zhao P. | 04/3/2021 |
| Both HDAC5 and p300 are involved in MRTF-A-mediated effect on neuronal apoptosis. | Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats.
Li N, Yuan Q, Cao XL, Zhang Y, Min ZL, Xu SQ, Yu ZJ, Cheng J, Zhang C, Hu XM., Free PMC Article | 11/4/2017 |
| sublytic C5b-9-induced activation of Egr-1/p300-ATF3/Gadd45 axis plays a critical role in glomerular mesangial cells apoptosis in Thy-1N rats. | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation.
He F, Zhou M, Yu T, Zhao D, Zhang J, Qiu W, Lu Y, Liu Y, Wang L, Wang Y. | 09/30/2017 |
| p300 is involved in the protective effect of SIRT6 against phenylephrine-induced cardiomyocyte hypertrophy | SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.
Shen P, Feng X, Zhang X, Huang X, Liu S, Lu X, Li J, You J, Lu J, Li Z, Ye J, Liu P. | 05/20/2017 |
| p300 phosphorylation at Ser-89 enhances p300/beta-catenin interaction, concurrent with alveolar epithelial cell differentiation. | p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).
Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z., Free PMC Article | 08/13/2016 |
| P300-dependent STAT3 acetylation is necessary for Ang II-induced STAT3 phosphorylation. | P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells.
Ni J, Shen Y, Wang Z, Shao DC, Liu J, Kong YL, Fu LJ, Zhou L, Xue H, Huang Y, Zhang W, Yu C, Lu LM., Free PMC Article | 09/5/2015 |
| These data implicate that sublytic C5b-9 induces the expression of both p300 and IRF-1, as well as p300-dependent IRF-1 acetylation that may contribute to XAF1 gene activation and subsequent glomerular mesangial cells apoptosis. | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via XAF1 gene activation mediated by p300-dependent IRF-1 acetylation.
Qiu W, Zhou J, Zhu G, Zhao D, He F, Zhang J, Lu Y, Yu T, Liu L, Wang Y., Free PMC Article | 05/23/2015 |
| Downregulation of p300 gene expression during the early canalicular stage may disrupt epithelial-mesenchymal signaling interactions, contributing to the development of hypoplastic lungs | Downregulation of p300 gene expression in airway mesenchyme of nitrofen-induced hypoplastic lungs.
Takahashi H, Friedmacher F, Fujiwara N, Hofmann A, Takahashi T, Puri P. | 12/6/2014 |
| High glucose increases the activity of the transcriptional co-regulator p300 which contributes to cardiac fibrosis and hypertrophy. | High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy.
Bugyei-Twum A, Advani A, Advani SL, Zhang Y, Thai K, Kelly DJ, Connelly KA., Free PMC Article | 11/8/2014 |
| Histone acetylation mediated by p300 is essential for regulation of GATA4 and myocyte enhancer factor (MEF)2C by bone morphogenetic protein (BMP)2 in cardiac myocytes. | p300-mediated histone acetylation is essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.
Zheng M, Zhu J, Lu T, Liu L, Sun H, Liu Z, Tian J. | 08/16/2014 |
| p300 and CBP are probably involved in the maintenance of neuropathic pain on spinal cord level. | Temporal distribution of p300/CBP immunoreactivity in the adult rat spinal dorsal horn following chronic constriction injury (CCI).
Zhu XY, Huang CS, Li Q, Guo QL, Wang Y, He X, Liao J. | 08/10/2013 |
| p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury. | p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI).
Zhu XY, Huang CS, Li Q, Chang RM, Song ZB, Zou WY, Guo QL., Free PMC Article | 06/8/2013 |
| Adenosine monophosphate-activated protein kinase (AMPK) inhibits transforming growth factor (TGF)-beta-induced fibrogenic property of hepatic stellate cells by regulating transcriptional coactivator p300. | AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300.
Lim JY, Oh MA, Kim WH, Sohn HY, Park SI. | 04/28/2012 |
| ATRA induces KLF4 acetylation by p300 and increases the ability of KLF4 to transactivate the mfn-2 promoter in VSMCs. | Krüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs.
Zhang R, Han M, Zheng B, Li YJ, Shu YN, Wen JK., Free PMC Article | 02/26/2011 |
| CBP/p300 and P/CAF are key players in neuronal outgrowth, acetylate histone H3 at K9-14 and the transcription factor p53, thereby initiating a pro-neuronal outgrowth transcriptional program. | HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation.
Gaub P, Tedeschi A, Puttagunta R, Nguyen T, Schmandke A, Di Giovanni S. | 01/15/2011 |
| PCAF cooperates with p300 and Runx2 to mediate PTH activation of MMP-13 transcription. | Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF.
Lee M, Partridge NC., Free PMC Article | 01/1/2011 |
| Sepsis-induced muscle wasting may be regulated by glucocorticoid-dependent hyperacetylation caused by increased p300 and reduced HDAC6 expression and activity. | Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle.
Alamdari N, Smith IJ, Aversa Z, Hasselgren PO., Free PMC Article | 09/13/2010 |
| findings define a novel SnoN-Ccd1 link that promotes axonal growth in the mammalian brain, with important implications for axonal development and regeneration | A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain.
Ikeuchi Y, Stegmüller J, Netherton S, Huynh MA, Masu M, Frank D, Bonni S, Bonni A., Free PMC Article | 08/27/2010 |
| p300 is dynamically associated with the dor gene. | Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation.
Chen YL, Monteith N, Law PY, Loh HH. | 07/12/2010 |
| The aldosterone/mineralocorticoid receptor system associates with the p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes. | Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes.
Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K. | 05/3/2010 |
| Cdk9 forms a functional complex with the p300/GATA4 and is required for p300/GATA4- transcriptional pathway during cardiomyocyte hypertrophy | Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K., Free PMC Article | 05/3/2010 |
| without altering the gross chromatin structure, PTH stimulates acetylation of histones H3 and H4 via recruitment of p300 to Runx2 bound to the MMP-13 promoter, resulting in gene activation | Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene.
Boumah CE, Lee M, Selvamurugan N, Shimizu E, Partridge NC., Free PMC Article | 01/21/2010 |
| Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. | Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3.
Pradeepa MM, Nikhil G, Hari Kishore A, Bharath GN, Kundu TK, Rao MR., Free PMC Article | 01/21/2010 |
| Dox reciprocally regulates p300 and p53 through ubiquitin-dependent pathways and that p300, by its ubiquitin ligase activity, is partially involved in the ubiquitin-dependent degradation of p53 in cardiac myocytes. | Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways.
Morimoto T, Fujita M, Kawamura T, Sunagawa Y, Takaya T, Wada H, Shimatsu A, Kita T, Hasegawa K. | 01/21/2010 |