| The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus. | The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus.
L'Estrange-Stranieri E, Gottschalk TA, Wright MD, Hibbs ML., Free PMC Article | 08/4/2024 |
| Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model. | Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model.
Tornillo G, Warrington L, Kendrick H, Higgins AT, Hay T, Beck S, Smalley MJ., Free PMC Article | 02/5/2024 |
| Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain. | Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.
Chu E, Mychasiuk R, Tsantikos E, Raftery AL, L'Estrange-Stranieri E, Dill LK, Semple BD, Hibbs ML., Free PMC Article | 11/2/2023 |
| STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN. | STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
Kashiwakura JI, Kawahara S, Inagaki I, Inui K, Saitoh K, Kagohashi K, Sasaki Y, Kobayashi F, Kitai Y, Muromoto R, Oritani K, Matsuda T. | 10/11/2023 |
| T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn[-/-] mice. | T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn(-/-) mice.
Ottens K, Schneider J, Satterthwaite AB., Free PMC Article | 08/14/2023 |
| Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. | Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis.
Li N, Lin G, Zhang H, Sun J, Gui M, Liu Y, Li W, Zhan Z, Li Y, Pan S, Liu J, Tang J. | 04/26/2023 |
| Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons. | Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons.
Li X, Yuan RR, Wang Q, Chai S, Zhang Z, Wang Y, Huang SH., Free PMC Article | 07/2/2022 |
| Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan. | Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan.
Roberts ME, Barvalia M, Silva JAFD, Cederberg RA, Chu W, Wong A, Tai DC, Chen S, Matos I, Priatel JJ, Cullis PR, Harder KW. | 02/27/2021 |
| Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells. | Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.
Kuga T, Yamane Y, Hayashi S, Taniguchi M, Yamaguchi N, Yamagishi N., Free PMC Article | 12/5/2020 |
| CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases. | CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.
Ma J, Abram CL, Hu Y, Lowell CA., Free PMC Article | 08/15/2020 |
| Data suggest that cell-specific E3 ubiquitin ligase c-Cbl (c-Cbl) expression builds cell specificity into the LYN proto-oncogene Src family tyrosine kinase tyrosine-protein kinase (LynA) checkpoint. | Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
Brian BF 4th, Jolicoeur AS, Guerrero CR, Nunez MG, Sychev ZE, Hegre SA, Sætrom P, Habib N, Drake JM, Schwertfeger KL, Freedman TS., Free PMC Article | 03/7/2020 |
| A loss of a single Src family kinase, Fgr or Lyn, reduced platelet-mediated monocyte recruitment in vitro and a significant reduction in the burden of atherosclerotic disease in Fgr(-/-) /ApoE(-/-) or Lyn(-/-) /ApoE(-/-) animals. | Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.
Harrison MJ, Chimen M, Hussain M, Iqbal AJ, Senis YA, Nash GB, Watson SP, Rainger GE., Free PMC Article | 11/2/2019 |
| data establish the LYN/FcgammaRIIB/SHIP1 signalosome in the context of FcepsilonRI activation, particularly at supra-optimal Ag concentrations. The fact that SHIP1 tyrosine phosphorylation/activation not only depends on FcgammaRIIB, highlights the necessity for its tight backup control. | IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells.
Gast M, Preisinger C, Nimmerjahn F, Huber M., Free PMC Article | 09/21/2019 |
| ABCG1-overexpressing EPCs showed increased migration and tube formation and differentiation via the Lck/Yes-related novel protein tyrosine kinase /Akt/endothelial NO synthase pathway. | Elevating ATP-binding cassette transporter G1 improves re-endothelialization function of endothelial progenitor cells via Lyn/Akt/eNOS in diabetic mice.
Shi Y, Lv X, Liu Y, Li B, Liu M, Yan M, Liu Y, Li Q, Zhang X, He S, Zhu M, He J, Zhu Y, Zhu Y, Ai D. | 05/18/2019 |
| Fyn and Lyn as important factors that promote Plasmacytoid dendritic cell responses. | Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.
Dallari S, Macal M, Loureiro ME, Jo Y, Swanson L, Hesser C, Ghosh P, Zuniga EI., Free PMC Article | 11/10/2018 |
| these findings demonstrated that Lyn overexpression ameliorated airway mucus hypersecretion by down-regulating STAT6 and its binding to the MUC5AC promoter. | Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation.
Wang X, Li Y, Luo D, Wang X, Zhang Y, Liu Z, Zhong N, Wu M, Li G., Free PMC Article | 11/3/2018 |
| A novel pancancer mechanism of Lyn-dependent control of epithelial-mesenchymal transition and role of this kinase in tumor progression. | Targeting Lyn regulates Snail family shuttling and inhibits metastasis.
Thaper D, Vahid S, Nip KM, Moskalev I, Shan X, Frees S, Roberts ME, Ketola K, Harder KW, Gregory-Evans C, Bishop JL, Zoubeidi A. | 09/30/2017 |
| these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis | Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.
Ban T, Sato GR, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T. | 09/23/2017 |
| These findings reveal that the function and regulation of Lyn during B1 cell B cell receptor signaling is distinct from other B cell subsets. | Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.
Skrzypczynska KM, Zhu JW, Weiss A., Free PMC Article | 09/16/2017 |
| A mutation in LYN, an inhibitory protein tyrosine kinase that is implicated in systemic autoimmunity, combines with an Aire mutation to provoke organ-specific autoimmunity. | LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL., Free PMC Article | 09/16/2017 |
| the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake. | The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ., Free PMC Article | 08/5/2017 |
| the Lyn mutation in NOD neutrophils is likely responsible for dysregulation of neutrophil adhesion and directed migration. | -NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis.
Wu Y, Hannigan M, Zhan L, Madri JA, Huang CK. | 05/20/2017 |
| Our studies indicate not only a concept of mucus hypersecretion in asthma that involves Lyn kinase but also an important therapeutic candidate for asthma. | Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma.
Wang X, Yang X, Li Y, Wang X, Zhang Y, Dai X, Niu B, Wu J, Yuan X, Xiong A, Liu Z, Zhong N, Wu M, Li G., Free PMC Article | 02/18/2017 |
| Together, the basal-state signaling checkpoint regulated by LynA expression and degradation and the signaling reorganization initiated by receptor clustering allow cells to discriminate optimally between pathogens and nonpathogens. | LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A., Free PMC Article | 07/2/2016 |
| Oxidized LDL-bound CD36 recruits an Na/K-ATPase-Lyn complex in macrophages that promotes atherosclerosis. | Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.
Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL., Free PMC Article | 06/11/2016 |