| Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2. | Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
Liu XH, Zhang LY, Liu XY, Zhang JG, Hu YY, Zhao CG, Xian XH, Li WB, Zhang M. | 06/7/2024 |
| N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats. | N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats.
Zhao J, Zhao Q, Mao S. | 01/15/2022 |
| MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. | MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.
Su X, Zhang H, Wang H, Sun P. | 09/25/2021 |
| Astrocytic NDRG2 is critical in the maintenance of neuropathic pain. | Astrocytic NDRG2 is critical in the maintenance of neuropathic pain.
Cheng H, Zhang L, Xia F, Jin L, Liu S, Ren H, Zhu C, Ji Q, Tang J. | 05/8/2021 |
| Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats. | Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
Wang Y, Zhai WL, Yang YW. | 04/3/2021 |
| Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats. | Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
Pu LJ, Chen W, Liu QH, Huang AP, Zhao Q, Gu HH. | 03/20/2021 |
| Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death. | The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
Rong XF, Sun YN, Liu DM, Yin HJ, Peng Y, Xu SF, Wang L, Wang XL., Free PMC Article | 06/9/2018 |
| 2-arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation. | 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.
Wang F, Li M, Li X, Kinden R, Zhou H, Guo F, Wang Q, Xiong L. | 03/18/2017 |
| Our results demonstrated that NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage. | NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
Tang LL, Wu YB, Fang CQ, Qu P, Gao ZL. | 05/28/2016 |
| We further showed that the localized delivery of NDRG2 improved the dysfunction of Na(+) and Cl(-) reabsorption | Retrograde ductal administration of the adenovirus-mediated NDRG2 gene leads to improved sialaden hypofunction in estrogen-deficient rats.
Li Y, Liu C, Hou W, Li Y, Ma J, Lin K, Situ Z, Xiong L, Li S, Yao L., Free PMC Article | 02/28/2015 |
| Our results indicated that NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats | NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats.
Wang F, Gao Z, Li X, Li Y, Li X, Zhong H, Xu N, Cao F, Wang Q, Xiong L. | 09/28/2013 |
| Results suggest a novel role of PI3K/Akt/NDRG2 signaling in the cardioprotective effect of insulin. | NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury.
Sun Z, Tong G, Ma N, Li J, Li X, Li S, Zhou J, Xiong L, Cao F, Yao L, Wang H, Shen L. | 08/31/2013 |
| Western blot analysis showed that the chronic stress downregulated GFAP but upregulated NDRG2 protein | Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus.
Araya-Callís C, Hiemke C, Abumaria N, Flugge G., Free PMC Article | 03/9/2013 |
| NDRG2 contributed to an increase in the ratio of matrix metalloproteinase 2 (MMP2) to tissue inhibitor of matrix metalloproteinase 2 | NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats.
Yang J, Zheng J, Wu L, Shi M, Zhang H, Wang X, Xia N, Wang D, Liu X, Yao L, Li Y, Dou K., Free PMC Article | 03/31/2012 |
| NDRG2 expression is up-regulated in ischemic penumbra following transient focal cerebral ischemia; NDRG2 expression in astrocytes may play an important pathological role in cell apoptosis after stroke. | Spatial-temporal expression of NDRG2 in rat brain after focal cerebral ischemia and reperfusion.
Li Y, Shen L, Cai L, Wang Q, Hou W, Wang F, Zeng Y, Zhao G, Yao L, Xiong L. | 11/19/2011 |
| A low level of NDRG2 was observed as the C-Myc expression increased during regeneration. Moreover, a dramatic cell cycle arrest was found in normal rat liver-derived BRL cells 48 hours after being infected by adenoviral vectors expressing rat NDRG2. | NDRG2 in rat liver regeneration: role in proliferation and apoptosis.
Yang J, Li Y, Wu L, Zhang Z, Han T, Guo H, Jiang N, Tao K, Ti Z, Liu X, Yao L, Dou K. | 03/5/2011 |
| These findings suggest that NDRG2 regulates testicular development and spermatogenesis in rats and is involved in the physiological and pathological apoptosis of germ cells. | Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development.
Hou WG, Zhao Y, Shen L, Zhao J, Liu XW, Li Z, Liu XP, Yao LB, Zhang YQ. | 01/21/2010 |
| NDRG2 is a likely candidate to contribute to aldosterone-mediated ENaC regulation | (NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells.
Wielpütz MO, Lee IH, Dinudom A, Boulkroun S, Farman N, Cook DI, Korbmacher C, Rauh R. | 01/21/2010 |
| Review concludes that the study of Ndrg2 regulation and function in glia could contribute to understanding the pathogenesis and treatment of depression. | Ndrg2, a novel gene regulated by adrenal steroids and antidepressants, is highly expressed in astrocytes.
Nichols NR. | 01/21/2010 |
| results indicate that NDRG2 regulation by aldosterone is an early mineralocorticoid-specific effect | Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene.
Boulkroun S, Fay M, Zennaro MC, Escoubet B, Jaisser F, Blot-Chabaud M, Farman N, Courtois-Coutry N. | 01/21/2010 |