| Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway. | Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H. | 02/29/2024 |
| Long non-coding RNA KCNQ10T1/miR-19a-3p/SMAD5 axis promotes osteogenic differentiation of mouse bone mesenchymal stem cells. | Long non-coding RNA KCNQ10T1/miR-19a-3p/SMAD5 axis promotes osteogenic differentiation of mouse bone mesenchymal stem cells.
Lin H, Nie L, Lu G, Wu H, Xu T., Free PMC Article | 12/18/2023 |
| BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy. | BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy.
Tang S, Cope DI, Vasquez YM, Monsivais D., Free PMC Article | 05/7/2022 |
| BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling. | BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.
Chai P, Yu J, Wang X, Ge S, Jia R., Free PMC Article | 12/4/2021 |
| Silencing of miR-330-5p stimulates osteogenesis in bone marrow mesenchymal stem cells and inhibits bone loss in osteoporosis by activating Bgn-mediated BMP/Smad pathway. | Silencing of miR-330-5p stimulates osteogenesis in bone marrow mesenchymal stem cells and inhibits bone loss in osteoporosis by activating Bgn-mediated BMP/Smad pathway.
Jin SL, Bai YM, Zhao BY, Wang QH, Zhang HS. | 04/3/2021 |
| BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development. | BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.
Benn A, Alonso F, Mangelschots J, Génot E, Lox M, Zwijsen A., Free PMC Article | 03/20/2021 |
| Maternal high protein-diet programs impairment of offspring's bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts. | Maternal high protein-diet programs impairment of offspring's bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts.
Ellur G, Sukhdeo SV, Khan MT, Sharan K., Free PMC Article | 03/6/2021 |
| a pathogenic role for both iron loading and SMAD1/5/8 deficiency in liver injury and fibrosis. | Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.
Wang CY, Xiao X, Bayer A, Xu Y, Dev S, Canali S, Nair AV, Masia R, Babitt JL., Free PMC Article | 07/4/2020 |
| The luciferase reporter assay confirmed a direct interaction between miR-132-3p and Smad5. Thus, miR-132-3p maybe regulates osteoblast differentiation via Smad5 in response to cyclic tensile stress. | MicroRNA-132-3p represses Smad5 in MC3T3-E1 osteoblastic cells under cyclic tensile stress.
Liu M, Sun F, Feng Y, Sun X, Li J, Fan Q, Liu M. | 07/20/2019 |
| SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors. | SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors.
Tasca A, Astleford K, Blixt NC, Jensen ED, Gopalakrishnan R, Mansky KC., Free PMC Article | 02/23/2019 |
| SMAD5 is crucial for expanding amniotic ectoderm rapidly into a stretchable squamous sheet to accommodate exocoelom expansion, axial growth and folding morphogenesis. | Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling.
Dobreva MP, Abon Escalona V, Lawson KA, Sanchez MN, Ponomarev LC, Pereira PNG, Stryjewska A, Criem N, Huylebroeck D, Chuva de Sousa Lopes SM, Aerts S, Zwijsen A., Free PMC Article | 08/4/2018 |
| miR-155 inhibited osteoblast differentiation by downregulating the translation of SMAD5 in mouse preosteoblast cells. Inhibition of miR-155 promoted osteogenic potential and thus it can be used as a potential target in the treatment of bone defects. | miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression.
Gu Y, Ma L, Song L, Li X, Chen D, Bai X., Free PMC Article | 02/17/2018 |
| Up-regulation of miR-93 may contribute to the progression of morphine tolerance by targeting Smad5 in mouse model of bone cancer pain | MicroRNA-93-5p may participate in the formation of morphine tolerance in bone cancer pain mouse model by targeting Smad5.
Xiao WF, Li YS, Lou W, Cai T, Zhang S, Hu XY, Zhang XW, Luo W., Free PMC Article | 01/13/2018 |
| Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2/RhoA/ROCK/Smad1/5/8 signaling. | Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.
Higashi K, Matsuzaki E, Hashimoto Y, Takahashi-Yanaga F, Takano A, Anan H, Hirata M, Nishimura F. | 12/23/2017 |
| We discovered that Smad1/5/4-Amhr2-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation. | SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice.
Rodriguez A, Tripurani SK, Burton JC, Clementi C, Larina I, Pangas SA., Free PMC Article | 10/21/2017 |
| these studies characterize an accessory TGF-beta-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung. | Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1.
Zhang H, Du L, Zhong Y, Flanders KC, Roberts JD Jr., Free PMC Article | 09/23/2017 |
| Thyroid-specific Smad1 and Smad5 double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture. | Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.
Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE., Free PMC Article | 09/2/2017 |
| Smad1 and Smad5 have overlapping functions to govern hepcidin transcription. Moreover, erythropoietin and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin expression. | Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.
Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL., Free PMC Article | 08/19/2017 |
| miR-106b-5p and miR-17-5p are novel Smad5 regulators. | miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation.
Fang T, Wu Q, Zhou L, Mu S, Fu Q. | 05/20/2017 |
| BetA can enhance in vivo osteogenic potentials of BMP2, possibly via stimulating Smad 1/5/8 and p38 pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases. | Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.
Choi H, Jeong BC, Kook MS, Koh JT., Free PMC Article | 02/4/2017 |
| Data show that in R-Smad proteins Smad1;Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD signaling is dispensable for self-renewal. | BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.
Gomes Fernandes M, Dries R, Roost MS, Semrau S, de Melo Bernardo A, Davis RP, Ramakrishnan R, Szuhai K, Maas E, Umans L, Abon Escalona V, Salvatori D, Deforce D, Van Criekinge W, Huylebroeck D, Mummery C, Zwijsen A, de Sousa Lopes SM., Free PMC Article | 11/5/2016 |
| Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs). | BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.
Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K., Free PMC Article | 11/5/2016 |
| The crystal structure of Smad5-MH1 domain in complex with a composite DNA sequence demonstrates that the MH1 domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 assembly. | Structural basis for the Smad5 MH1 domain to recognize different DNA sequences.
Chai N, Li WX, Wang J, Wang ZX, Yang SM, Wu JW., Free PMC Article | 05/14/2016 |
| The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2/Smad1/5/8 and Wnt/beta-catenin pathways. | KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.
Liou SF, Hsu JH, Chu HC, Lin HH, Chen IJ, Yeh JL. | 08/8/2015 |
| FLI1 and GATA2 are upstream regulators of SMAD1 and SMAD5 expression in endothelial cells. | SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.
Marks-Bluth J, Khanna A, Chandrakanthan V, Thoms J, Bee T, Eich C, Kang YC, Knezevic K, Qiao Q, Fitch S, Oxburgh L, Ottersbach K, Dzierzak E, de Bruijn MF, Pimanda JE., Free PMC Article | 08/8/2015 |