| NLRP6 negatively regulates host defense against polymicrobial sepsis. | NLRP6 negatively regulates host defense against polymicrobial sepsis.
Ghimire L, Paudel S, Le J, Jin L, Cai S, Bhattarai D, Jeyaseelan S., Free PMC Article | 06/10/2024 |
| Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes. | Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes.
Frühbeck G, Gómez-Ambrosi J, Ramírez B, Becerril S, Rodríguez A, Mentxaka A, Valentí V, Moncada R, Reina G, Baixauli J, Casado M, Silva C, Escalada J, Catalán V., Free PMC Article | 03/8/2024 |
| NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment. | NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment.
Chang L, Xu L, Tian Y, Liu Z, Song M, Li S, Zhang X, Chen Y, Hao Q, Lu Y, Zhen Y. | 02/21/2024 |
| NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85alpha to drive tumorigenesis. | NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis.
Zhi F, Li B, Zhang C, Xia F, Wang R, Xie W, Cai S, Zhang D, Kong R, Hu Y, Yang Y, Peng Y, Cui J., Free PMC Article | 10/2/2023 |
| A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients. | A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients.
Gao X, Wang WX, Zhang XL., Free PMC Article | 01/28/2023 |
| NLRP3 and NLRP6 expression in pterygium and normal conjunctiva and their relationship with pterygium formation and recurrence. | NLRP3 and NLRP6 expression in pterygium and normal conjunctiva and their relationship with pterygium formation and recurrence.
Guo Z, Wang Y, Wang L, Li Q, Yuan X, Hua X. | 08/20/2022 |
| Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles. | Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles.
Angosto-Bazarra D, Molina-López C, Pelegrín P., Free PMC Article | 06/11/2022 |
| Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia. | Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.
Bruce JK, Burns GL, Sinn Soh W, Nair PM, Sherwin S, Fan K, Dowling LR, Goggins BJ, Koloski N, Potter M, Bollipo S, Foster R, Gan LT, Veysey M, Philpott DJ, Girardin SE, Holtmann G, Kaiko GE, Walker MM, Talley NJ, Keely S. | 05/7/2022 |
| A detrimental role of NLRP6 in host iron metabolism during Salmonella infection. | A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
Deng Q, Yang S, Sun L, Huang K, Dong K, Zhu Y, Cao Y, Li Y, Wu S, Huang R., Free PMC Article | 03/12/2022 |
| Candida albicans SC5314 inhibits NLRP3/NLRP6 inflammasome expression and dampens human intestinal barrier activity in Caco-2 cell monolayer model. | Candida albicans SC5314 inhibits NLRP3/NLRP6 inflammasome expression and dampens human intestinal barrier activity in Caco-2 cell monolayer model.
Mao X, Qiu X, Jiao C, Lu M, Zhao X, Li X, Li J, Ma J, Zhang H. | 07/31/2021 |
| NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation. | NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.
Tian XX, Li R, Liu C, Liu F, Yang LJ, Wang SP, Wang CL. | 05/15/2021 |
| NLRP6 suppresses gastric cancer growth via GRP78 ubiquitination. | NLRP6 suppresses gastric cancer growth via GRP78 ubiquitination.
Wang X, Wu X, Wang Q, Zhang Y, Wang C, Chen J. | 03/6/2021 |
| Long noncoding RNA OIP5-AS1 aggravates cell proliferation, migration in gastric cancer by epigenetically silencing NLRP6 expression via binding EZH2. | Long noncoding RNA OIP5-AS1 aggravates cell proliferation, migration in gastric cancer by epigenetically silencing NLRP6 expression via binding EZH2.
Bai Y, Li S. | 02/27/2021 |
| Expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 in human dental pulp tissues and cells. | Expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 in human dental pulp tissues and cells.
Zhao Y, Chen L, Shen Z, Li J, Huang S, Wang R, Lin Z, Song Z. | 11/28/2020 |
| Loss of NLRP6 expression increases the severity of acute kidney injury. | Loss of NLRP6 expression increases the severity of acute kidney injury.
Valiño-Rivas L, Cuarental L, Nuñez G, Sanz AB, Ortiz A, Sanchez-Niño MD. | 10/31/2020 |
| Overexpression of NLRP6 in Caco-2 and IEC-6cells suppress the increase apoptosis induced by miR-650 overexpression. | microRNA-650 promotes inflammation induced apoptosis of intestinal epithelioid cells by targeting NLRP6.
Xu X, Zhu X, Wang C, Li Y, Fan C, Kao X. | 06/20/2020 |
| Differential expression pattern of various of NLRP3, NLRC4 and NLRP6 inflammasomes were observed in primary immune thrombocytopenia patients. | Aberrant expression of NLRP3, NLRC4 and NLRP6 inflammasomes in patients with primary immune thrombocytopenia.
Lv Y, Ruan G, Liu Y, Cui D, Zhao Y, Yan C, Lv M, Xu D, Mao Y, Cao J, Jin J, Xie J. | 12/14/2019 |
| Studied expression of NLR family pyrin domain containing 6 (NLRP6) in colon of patients with Hirschsprung's disease (HSCR) and found decreased expression of NLRP6 may contribute to colonic microbiome changes and increase the susceptibility to develop Hirschsprung's associated enterocolitis. | Reduced expression of the NLRP6 inflammasome in the colon of patients with Hirschsprung's disease.
Tomuschat C, Virbel CR, O'Donnell AM, Puri P. | 11/23/2019 |
| that NLRP6 exerts anti-fibrotic effects in LX-2 cells via regulating PPM1A/Smad2/3 and that NLRP6 may be an effective target in the treatment of liver fibrosis | Effects of NLRP6 on the proliferation and activation of human hepatic stellate cells.
Zhu Y, Ni T, Deng W, Lin J, Zheng L, Zhang C, Luo M. | 10/5/2019 |
| NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, participates in the progression of intestinal inflammation and enteric pathogen infections. [review] | The protective roles of NLRP6 in intestinal epithelial cells.
Yin J, Sheng B, Yang K, Sun L, Xiao W, Yang H., Free PMC Article | 04/20/2019 |
| this review discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease | NLRP6: A Multifaceted Innate Immune Sensor.
Levy M, Shapiro H, Thaiss CA, Elinav E. | 09/16/2017 |
| Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38) | NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes.
Lin Y, Luo Z. | 08/12/2017 |
| Our results revealed an association between NLRP6/AVR and ADM loci with male essential hypertension, suggesting the existence of sex-specific NLRP6/AVR and ADM variants affecting male susceptibility to essential hypertension. | Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population.
Glorioso N, Herrera VL, Didishvili T, Ortu MF, Zaninello R, Fresu G, Argiolas G, Troffa C, Ruiz-Opazo N., Free PMC Article | 08/9/2014 |
| We will focus on NLRP6 and NLRP12. | Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis.
Chen GY., Free PMC Article | 04/26/2014 |
| NLRP6 is a newly characterized member of this family that inhibits NF-kappaB and MAP-kinase dependent immune signaling to hamper anti-microbial defense. | NLRP6 in infection and inflammation.
Anand PK, Kanneganti TD., Free PMC Article | 03/29/2014 |