| A Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity, and Inflammation. | A Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity, and Inflammation.
Anbazhagan AN, Ge Y, Priyamvada S, Kumar A, Jayawardena D, Palani ARV, Husain N, Kulkarni N, Kapoor S, Kaur P, Majumder A, Lin YD, Maletta L, Gill RK, Alrefai WA, Saksena S, Zadeh K, Hong S, Mohamadzadeh M, Dudeja PK. | 09/3/2024 |
| A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts. | A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.
Su S, Wahl A, Rugis J, Suresh V, Yule DI, Sneyd J., | 05/6/2024 |
| Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells. | Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
Shin S, Awuah Boadi E, Bandyopadhyay BC., Free PMC Article | 02/14/2023 |
| A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes. | A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes.
Borgo GM, Burke TP, Tran CJ, Lo NTN, Engström P, Welch MD., Free PMC Article | 07/2/2022 |
| The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine. | The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine.
Whittamore JM, Hatch M., Free PMC Article | 12/4/2021 |
| Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease. | Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.
Neumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F., Free PMC Article | 03/6/2021 |
| Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6. | Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.
Hatch M., Free PMC Article | 11/21/2020 |
| Slc26a6 is an apical membrane anion exchanger that drives HCO3(-)-dependent fluid secretion in murine pancreatic acinar cells. | Slc26a6 is an apical membrane anion exchanger that drives HCO(3)(-)-dependent fluid secretion in murine pancreatic acinar cells.
Munemasa T, Mukaibo T, Melvin JE., Free PMC Article | 04/11/2020 |
| these data suggest that PAT1 is a new actor in transferrin early endocytosis. Whether this new function of PAT1 may have consequences in pathology remains to be determined. | Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis.
Dilsizoglu Senol A, Tagliafierro L, Gorisse-Hussonnois L, Rebeillard F, Huguet L, Geny D, Contremoulins V, Corlier F, Potier MC, Chasseigneaux S, Darmon M, Allinquant B., Free PMC Article | 12/14/2019 |
| SLC26A6 is dispensable for renal NaCl homeostasis, but it is required for net renal secretion of oxalate. | Characterization of renal NaCl and oxalate transport in Slc26a6(-/-) mice.
Knauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS., Free PMC Article | 11/30/2019 |
| findings indicate that Slc26a6 is located at the apical membrane of salivary gland acinar cells, where it mediates Cl(-)/oxalate exchange and plays a critical role in the secretion of oxalate into saliva. | The apical anion exchanger Slc26a6 promotes oxalate secretion by murine submandibular gland acinar cells.
Mukaibo T, Munemasa T, George AT, Tran DT, Gao X, Herche JL, Masaki C, Shull GE, Soleimani M, Melvin JE., Free PMC Article | 12/29/2018 |
| Slc26a6 is a unique cardiac electrogenic Cl(-)/HCO3(-) transporter in ventricular myocytes, which has roles in regulating pHi, excitability, and contractility. | Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6.
Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD., Free PMC Article | 10/28/2017 |
| This study showed that transepithelial sulfate fluxes across the mouse distal ileum demonstrating that DRA (and to a lesser extent, PAT1) secretes sulfate with significant implications for intestinal sulfate absorption and overall homeostasis. | Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.
Whittamore JM, Hatch M., Free PMC Article | 09/23/2017 |
| Enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity. | N-glycosylation critically regulates function of oxalate transporter SLC26A6.
Thomson RB, Thomson CL, Aronson PS., Free PMC Article | 06/10/2017 |
| Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation. | SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
Yin K, Lei Y, Wen X, Lacruz RS, Soleimani M, Kurtz I, Snead ML, White SN, Paine ML., Free PMC Article | 07/2/2016 |
| expressed in ameloblasts but not alone critical for formation of dental enamel | Slc26a3/Dra and Slc26a6 in Murine Ameloblasts.
Jalali R, Zandieh-Doulabi B, DenBesten PK, Seidler U, Riederer B, Wedenoja S, Micha D, Bronckers AL., Free PMC Article | 04/16/2016 |
| Results suggest that PAT1 slows down APP trafficking to the cell surface in primary cortical neurons | PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons.
Dilsizoglu Senol A, Tagliafierro L, Huguet L, Gorisse-Hussonnois L, Chasseigneaux S, Allinquant B., Free PMC Article | 01/16/2016 |
| Both PAT-1 and DRA significantly contribute to intestinal fluid absorption and enterocyte acid/base balance but are activated by different ion gradients. | The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.
Xia W, Yu Q, Riederer B, Singh AK, Engelhardt R, Yeruva S, Song P, Tian DA, Soleiman M, Seidler U., Free PMC Article | 02/28/2015 |
| Cardiac myocytes express different isoforms of Slc26a6, which encode electrogenic Cl(-)/HCO3(-) and Cl(-)/oxalate exchangers. | Slc26a6 functions as an electrogenic Cl-/HCO3- exchanger in cardiac myocytes.
Kim HJ, Myers R, Sihn CR, Rafizadeh S, Zhang XD. | 07/5/2014 |
| Slc26a6-null mice exhibited increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1. | SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis.
Ohana E, Shcheynikov N, Moe OW, Muallem S., Free PMC Article | 11/30/2013 |
| NMR and CE were used to characterize the urinary metabolome in slc26a6 null mice. Clear metabolic differentiation between the urinary profiles of the slc26a6 null and the wild type mice were observed using both methods. | Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model.
Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E., Free PMC Article | 03/30/2013 |
| SLC26A6 mediates 1:2 Cl-/HCO3- exchange, and the exchanger most probably upregulates SLC26A3 in its absence, therefore mediating 2:1 exchange. | Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.
Song Y, Yamamoto A, Steward MC, Ko SB, Stewart AK, Soleimani M, Liu BC, Kondo T, Jin CX, Ishiguro H., Free PMC Article | 01/5/2013 |
| Data demonstrate functional Pat-1 Cl)/HCO3) exchange activity in the lower villus epithelium of the murine duodenum which, in previous studies, had been obscured by the inclusion of luminal glucose as a metabolic substrate. | Functional activity of Pat-1 (Slc26a6) Cl(−)/HCO₃(−) exchange in the lower villus epithelium of murine duodenum.
Walker NM, Simpson JE, Hoover EE, Brazill JM, Schweinfest CW, Soleimani M, Clarke LL., Free PMC Article | 04/16/2011 |
| This study showed a functionally active CFTR is an absolute requirement for Slc26-mediated duodenal bicarbonate secretion, but not for Slc26-mediated fluid absorption. | The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.
Singh AK, Riederer B, Chen M, Xiao F, Krabbenhöft A, Engelhardt R, Nylander O, Soleimani M, Seidler U., Free PMC Article | 05/31/2010 |
| study concludes Pat-1 Cl(-)/HCO(3)(-) exchange contributes to pH(i) regulation in the duodenal villous epithelium during H(+)-dipeptide absorption, possibly by providing a HCO(3)(-) import pathway | Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.
Simpson JE, Walker NM, Supuran CT, Soleimani M, Clarke LL., Free PMC Article | 05/10/2010 |