| DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling. | DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling.
Li H, Yang Z, Liang W, Nie H, Guan Y, Yang N, Ji T, Liu Y, Huang Y, Zhang L, Yan J, Zhang C., Free PMC Article | 03/20/2024 |
| High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-beta hydroxycholesterol 24 reductase (DHCR24). | High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-β hydroxycholesterol 24 reductase (DHCR24).
Lu Z, Wang H, Zhang X, Huang X, Jiang S, Li Y, Liu T, Lu X, Gao B. | 09/12/2023 |
| Cellular cholesterol loss by DHCR24 knockdown leads to Abeta production by changing APP intracellular localization. | Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization.
Huang Y, Zhang W, Guo X, Zhang Y, Wu J, Zu H., Free PMC Article | 05/28/2023 |
| LncRNA ENST00000370438 promotes cell proliferation by upregulating DHCR24 in breast cancer. | LncRNA ENST00000370438 promotes cell proliferation by upregulating DHCR24 in breast cancer.
Yan L, Wu X, Zhang Y, Tan Q, Xu J, Wang Y, Wang R, Li Y, Zhao J. | 05/13/2023 |
| Anticancer peptide Q7 suppresses the growth and migration of human endometrial cancer by inhibiting DHCR24 expression and modulating the AKT-mediated pathway. | Anticancer peptide Q7 suppresses the growth and migration of human endometrial cancer by inhibiting DHCR24 expression and modulating the AKT-mediated pathway.
Chen CH, Weng TH, Huang KY, Kao HJ, Liao KW, Weng SL., Free PMC Article | 12/17/2022 |
| Hsa_circ_0003221 facilitates the malignant development of bladder cancer cells via resulting in the upregulation of DHCR24 by targeting miR-892b. | Hsa_circ_0003221 facilitates the malignant development of bladder cancer cells via resulting in the upregulation of DHCR24 by targeting miR-892b.
Lu P, Jiang Y, Xia Z., Free PMC Article | 09/17/2022 |
| The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis. | The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis.
Bai X, Mai M, Yao K, Zhang M, Huang Y, Zhang W, Guo X, Xu Y, Zhang Y, Qurban A, Duan L, Bu J, Zhang J, Wu J, Zhao Y, Yuan X, Zu H., Free PMC Article | 07/30/2022 |
| 24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation. | 24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation.
Yao M, Li F, Xu L, Ma L, Zhang S., Free PMC Article | 02/26/2022 |
| Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2+ diffuse large B-cell lymphomas. | Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2+ diffuse large B-cell lymphomas.
Shen Y, Zhou J, Nie K, Cheng S, Chen Z, Wang W, Wei W, Jiang D, Peng Z, Ren Y, Zhang Y, Fan Q, Richards KL, Qi Y, Cheng J, Tam W, Ma J., Free PMC Article | 02/26/2022 |
| A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents. | A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents.
Sliz E, Shin J, Syme C, Patel Y, Parker N, Richer L, Gaudet D, Bennett S, Paus T, Pausova Z., Free PMC Article | 01/29/2022 |
| DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells. | DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
Qi Z, Zhang Y, Yao K, Zhang M, Xu Y, Zhang J, Bai X, Zu H. | 10/23/2021 |
| Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24. | Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24.
Allen LB, Genaro-Mattos TC, Anderson A, Porter NA, Mirnics K, Korade Z., Free PMC Article | 07/31/2021 |
| Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. | Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression.
Kohlhaas J, Jäger MA, Lust L, De La Torre C, Hecker M, Korff T. | 06/12/2021 |
| Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase. | Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase.
Tallorin L, Villareal VA, Hsia CY, Rodgers MA, Burri DJ, Pfeil MP, Llopis PM, Lindenbach BD, Yang PL., Free PMC Article | 01/23/2021 |
| 24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway. | 24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway.
Qiu T, Cao J, Chen W, Wang J, Wang Y, Zhao L, Liu M, He L, Wu G, Li H, Gu H., Free PMC Article | 12/19/2020 |
| the E3 ubiquitin ligase membrane-associated ring-CH-type finger 6 (MARCH6), known to control earlier rate-limiting steps in cholesterol synthesis, also control levels of LDM and the terminal cholesterol synthesis enzyme, 24-dehydrocholesterol reductase. | The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ., Free PMC Article | 07/4/2020 |
| MiR-124 targeting Dhcr24 regulates oxidative stress and hypoxia induced cardiomyocyte apoptosis. | MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24.
Han F, Chen Q, Su J, Zheng A, Chen K, Sun S, Wu H, Jiang L, Xu X, Yang M, Yang F, Zhu J, Zhang L. | 06/27/2020 |
| The crucial role of the insulin/STAT3/DHCR24/PGR axis in the progression of endometrial carcinoma. | Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Dai M, Zhu XL, Liu F, Xu QY, Ge QL, Jiang SH, Yang XM, Li J, Wang YH, Wu QK, Ai ZH, Teng YC, Zhang ZG., Free PMC Article | 10/27/2018 |
| DHCR24 might be a therapeutic target for patients with bladder cancer | DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study.
Liu XP, Yin XH, Meng XY, Yan XH, Cao Y, Zeng XT, Wang XH., Free PMC Article | 10/13/2018 |
| Mutation in DHCR24 gene cause desmosterolosis presenting with multiple congenital anomalies with increased level of the cholesterol precursor desmosterol while disrupting development of cholesterol, impacting embryogenesis. | Desmosterolosis presenting with multiple congenital anomalies.
Rohanizadegan M, Sacharow S., Free PMC Article | 09/22/2018 |
| Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls. | Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study.
Kazmi N, Gaunt TR, Relton C, Micali N., Free PMC Article | 07/14/2018 |
| the expanding database of post-translational modifications will be a valuable resource for mapping the topology of membrane-associated proteins, such as DHCR24, that is, flagging cytosolic residues accessible to modifying enzymes such as kinases and ubiquitin ligases. | DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme.
Zerenturk EJ, Sharpe LJ, Brown AJ., Free PMC Article | 01/13/2018 |
| DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP-negative hepatocellular carcinoma. | Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Ezzikouri S, Kimura K, Sunagozaka H, Kaneko S, Inoue K, Nishimura T, Hishima T, Kohara M, Tsukiyama-Kohara K., Free PMC Article | 08/20/2016 |
| physical and functional interaction between DHCR24 and DHCR7 | The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally.
Luu W, Hart-Smith G, Sharpe LJ, Brown AJ., Free PMC Article | 12/19/2015 |
| In vitro experiments showed that DHCR24 overexpression induced tumor proliferation. | DHCR24 is an independent predictor of progression in patients with non-muscle-invasive urothelial carcinoma, and its functional role is involved in the aggressive properties of urothelial carcinoma cells.
Lee GT, Ha YS, Jung YS, Moon SK, Kang HW, Lee OJ, Joung JY, Choi YH, Yun SJ, Kim WJ, Kim IY. | 10/3/2015 |