| Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers. | Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers.
Mendez-Frausto G, Uresti-Rivera EE, Godina-Gonzalez S, Portales-Perez DP, Gonzalez-Amaro R, Garcia-Hernandez MH. | 12/25/2021 |
| Analyses also revealed that the coiled-coil domain common to all three MBD3 isoforms, but not the MBD domain, plays a crucial role in this activity. | Identification of the Coiled-Coil Domain as an Essential Methyl-CpG-Binding Domain Protein 3 Element for Preserving Lineage Commitment Potential of Embryonic Stem Cells.
Hirasaki M, Ueda A, Asaka MN, Uranishi K, Suzuki A, Kohda M, Mizuno Y, Okazaki Y, Nishimoto M, Sharif J, Koseki H, Okuda A. | 12/7/2019 |
| It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly. | Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.
Mor N, Rais Y, Sheban D, Peles S, Aguilera-Castrejon A, Zviran A, Elinger D, Viukov S, Geula S, Krupalnik V, Zerbib M, Chomsky E, Lasman L, Shani T, Bayerl J, Gafni O, Hanna S, Buenrostro JD, Hagai T, Masika H, Vainorius G, Bergman Y, Greenleaf WJ, Esteban MA, Elling U, Levin Y, Massarwa R, Merbl Y, Novershtern N, Hanna JH., Free PMC Article | 10/5/2019 |
| It has been shown that chromatin localization of Mbd2 and Mbd3 is highly overlapping, and both proteins are interdependent for chromatin association. | DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells.
Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG., Free PMC Article | 11/18/2017 |
| controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program | Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.
Loughran SJ, Comoglio F, Hamey FK, Giustacchini A, Errami Y, Earp E, Göttgens B, Jacobsen SEW, Mead AJ, Hendrich B, Green AR., Free PMC Article | 10/28/2017 |
| Smek/Mbd3 interaction regulates neuronal gene expression and neuronal differentiation during cortical development. | Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis.
Moon BS, Yun HM, Chang WH, Steele BH, Cai M, Choi SH, Lu W., Free PMC Article | 08/26/2017 |
| This work revealed the critical function of miR-134-Mbd3 axis on regulating reprogramming and pluripotency of induced pluripotent stem cells derived from the neural progenitor cells. | MiR-134-Mbd3 axis regulates the induction of pluripotency.
Zhang L, Zheng Y, Sun Y, Zhang Y, Yan J, Chen Z, Jiang H., Free PMC Article | 07/8/2017 |
| Cigarette smoke induces proteosomal-mediated degradation of Mbd-3 in embryonic orofacial cells. | Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells.
Mukhopadhyay P, Greene RM, Pisano MM., Free PMC Article | 10/1/2016 |
| Although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes. | The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex.
Knock E, Pereira J, Lombard PD, Dimond A, Leaford D, Livesey FJ, Hendrich B., Free PMC Article | 01/23/2016 |
| overexpression facilitates NANOG-mediated reprogramming in neural stem cells | MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner.
dos Santos RL, Tosti L, Radzisheuskaya A, Caballero IM, Kaji K, Hendrich B, Silva JC., Free PMC Article | 05/16/2015 |
| Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos. | The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos.
Linke M, May A, Reifenberg K, Haaf T, Zechner U. | 04/6/2013 |
| cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes | A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells.
Kim JJ, Khalid O, Vo S, Sun HH, Wong DT, Kim Y., Free PMC Article | 02/9/2013 |
| Study finds that Mbd3 and Brg1 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 play key roles in the biology of 5-hydroxymethylcytosine. | Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG., Free PMC Article | 02/25/2012 |
| the transactivation domain of c-Jun recruits Mbd3/NuRD to AP-1 target genes to mediate gene repression, and this repression is relieved by JNK-mediated c-Jun N-terminal phosphorylation | c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.
Aguilera C, Nakagawa K, Sancho R, Chakraborty A, Hendrich B, Behrens A. | 02/26/2011 |
| Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells | Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation.
Zhu D, Fang J, Li Y, Zhang J., Free PMC Article | 05/3/2010 |
| Methyl-CpG binding domain 3b (Mbd3b) protein is a novel binding partner of Evi1, i.e., a member of the Mi-2/NuRD histone deacetylase complex. | Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD.
Spensberger D, Vermeulen M, Le Guezennec X, Beekman R, van Hoven A, Bindels E, Stunnenberg H, Delwel R. | 01/21/2010 |
| Chromatin immunoprecipitation shows that MBD3 is bound to the H19 DMD; MBD3-depleted preimplantation embryos have reduced cell numbers, suggesting a role for MBD3 in cell division. | Maintenance of paternal methylation and repression of the imprinted H19 gene requires MBD3.
Reese KJ, Lin S, Verona RI, Schultz RM, Bartolomei MS., Free PMC Article | 01/21/2010 |
| MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing | MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
Jin SG, Jiang CL, Rauch T, Li H, Pfeifer GP. | 01/21/2010 |
| MBD3 protein is differentially expressed in principal neurons of the hippocampus and cortex, and in the adult retina. | Differential expression of methyl CpG-binding domain containing factor MBD3 in the developing and adult rat brain.
Jung BP, Zhang G, Nitsch R, Trogadis J, Nag S, Eubanks JH. | 01/21/2010 |
| These results demonstrate the importance of Mbd3/NuRD for the development of pluripotent cells in vivo. | Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
Kaji K, Nichols J, Hendrich B. | 01/21/2010 |
| A 1072 base pair fragment of the MBD3 promoter is sufficient to drive expression in cell lines and primary cultured neurons. | Identification of a murine methyl cytosine phosphate guanine binding domain-containing factor 3 (MBD3) promoter segment sufficient for driving reporter gene expression in neurons in vitro and in vivo.
Jung BP, Purushotham D, Eubanks JH. | 01/21/2010 |
| Mbd3-deficient embryonic stem cells could be maintained in the absence of leukaemia inhibitory factor (LIF) and could initiate differentiation in embryoid bodies or chimeric embryos, but failed to commit to developmental lineages. | The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.
Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B. | 01/21/2010 |
| Component of Mi-2 chromatin remodelling and histone deacetylation complex in Xenopus laevis oocytes | Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP. | 12/1/2000 |
| Component of Nucleosome Remodelling and Histone Deacetylation (NuRD) co-repressor complex | Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D., Free PMC Article | 12/1/2000 |