| Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy. | Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy.
Thapa K, Ghimire B, Pokharel K, Cai M, Savontaus E, Rinne P., Free PMC Article | 10/25/2024 |
| LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion. | LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion.
Liu Y, Liu F, Li Y, Li Y, Feng Y, Zhao J, Zhou C, Li C, Shen J, Zhang Y., Free PMC Article | 03/5/2024 |
| Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease. | Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease.
Srivastava P, Nishiyama S, Zhou F, Lin SH, Srivastava A, Su C, Xu Y, Peng W, Levy M, Schwarzschild M, Chen X., Free PMC Article | 01/11/2024 |
| Genealogical characterization of regional populations and dorsal coat color variation in the house mouse Mus musculus from Asia based on haplotype structure analysis of a gene-rich region harboring Mc1r. | Genealogical characterization of regional populations and dorsal coat color variation in the house mouse Mus musculus from Asia based on haplotype structure analysis of a gene-rich region harboring Mc1r.
Zakoh K, Fujiwara K, Takada T, Osada N, Suzuki H. | 09/12/2023 |
| Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy. | Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy.
Guan X, Chen B, Malhotra DK, Gohara AF, Dworkin LD, Gong R., Free PMC Article | 01/28/2023 |
| Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. | Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.
Cai W, Srivastava P, Feng D, Lin Y, Vanderburg CR, Xu Y, Mclean P, Frosch MP, Fisher DE, Schwarzschild MA, Chen X., Free PMC Article | 04/16/2022 |
| Melanocortin 1 Receptor Deficiency in Hematopoietic Cells Promotes the Expansion of Inflammatory Leukocytes in Atherosclerotic Mice. | Melanocortin 1 Receptor Deficiency in Hematopoietic Cells Promotes the Expansion of Inflammatory Leukocytes in Atherosclerotic Mice.
Kadiri JJ, Tadayon S, Thapa K, Suominen A, Hollmén M, Rinne P., Free PMC Article | 02/12/2022 |
| Mouse Hair Significantly Lightened Through Replacement of the Cysteine Residue in the N-Terminal Domain of Mc1r Using the CRISPR/Cas9 System. | Mouse Hair Significantly Lightened Through Replacement of the Cysteine Residue in the N-Terminal Domain of Mc1r Using the CRISPR/Cas9 System.
Suzuki H, Kinoshita G, Tsunoi T, Noju K, Araki K. | 10/16/2021 |
| Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice. | Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice.
Fu S, Luo X, Wu X, Zhang T, Gu L, Wang Y, Gao M, Cheng Y, Xie Z., Free PMC Article | 05/22/2021 |
| Deficiency in MC1-R signaling exacerbates atherosclerosis by disturbing cholesterol handling and by increasing arterial monocyte accumulation. | Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E(-/-) Mice.
Rinne P, Kadiri JJ, Velasco-Delgado M, Nuutinen S, Viitala M, Hollmén M, Rami M, Savontaus E, Steffens S., Free PMC Article | 01/19/2019 |
| These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth. | Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.
Thomas AC, Heux P, Santos C, Arulvasan W, Solanky N, Carey ME, Gerrelli D, Kinsler VA, Etchevers HC., Free PMC Article | 09/1/2018 |
| Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms. | MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy.
Qiao Y, Berg AL, Wang P, Ge Y, Quan S, Zhou S, Wang H, Liu Z, Gong R., Free PMC Article | 04/28/2018 |
| results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma | Palmitoylation-dependent activation of MC1R prevents melanomagenesis.
Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R., Free PMC Article | 03/3/2018 |
| We conclude that MC1R plays an important role in regulating melanoma growth and morphology | Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival.
Kansal RG, McCravy MS, Basham JH, Earl JA, McMurray SL, Starner CJ, Whitt MA, Albritton LM., Free PMC Article | 01/13/2018 |
| Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation. | Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.
Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki T, Weber C, Steffens S., Free PMC Article | 09/2/2017 |
| MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours. | Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.
Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ, Gavins FN., Free PMC Article | 11/21/2015 |
| MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins | Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus.
Silva MA, Cau SB, Lopes RA, Manzato CP, Neves KB, Bruder-Nascimento T, Mestriner FL, Montezano AC, Nguyen Dinh Cat A, Touyz RM, Tostes RC. | 10/10/2015 |
| MC1 has an endogenous regulatory function in collagen synthesis and controls the extent of fibrotic stress responses of the skin. | Bleomycin-induced fibrosis in MC1 signalling-deficient C57BL/6J-Mc1r(e/e) mice further supports a modulating role for melanocortins in collagen synthesis of the skin.
Böhm M, Stegemann A. | 04/4/2015 |
| A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor-dependent melanoma. | A melanin-independent interaction between Mc1r and Met signaling pathways is required for HGF-dependent melanoma.
Wolnicka-Glubisz A, Strickland FM, Wielgus A, Anver M, Merlino G, De Fabo EC, Noonan FP., Free PMC Article | 02/21/2015 |
| In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE cell damage, and might minimize the risk of developing AMD. | Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling.
Cheng LB, Cheng L, Bi HE, Zhang ZQ, Yao J, Zhou XZ, Jiang Q. | 03/15/2014 |
| Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression. | Functional melanocortin 1 receptor Mc1r is not necessary for an inflammatory response to UV radiation in adult mouse skin.
Wolnicka-Glubisz A, De Fabo E, Noonan F., Free PMC Article | 09/28/2013 |
| MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases. | The melanocortin 1 receptor (MC1R) inhibits the inflammatory response in Raw 264.7 cells and atopic dermatitis (AD) mouse model.
Chen W, Li J, Qu H, Song Z, Yang Z, Huo J, Jiang H, Huang Q, Huo M, Liu B, Zhang Q. | 06/22/2013 |
| Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice. | Melanocortin receptors 1 and 5 might mediate inhibitory effects of α-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Etori M, Yonekubo K, Sato E, Mizukami K, Hirahara K, Karasuyama H, Maeda H, Yamashita M. | 08/25/2012 |
| MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression. | Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression.
Chung H, Lee JH, Jeong D, Han IO, Oh ES., Free PMC Article | 08/25/2012 |
| Spatiotemporal localization of MC1R and alpha-MSH in cutaneous wounds warrants future investigation into the role of MC1R/alpha-MSH signaling in the inflammatory and fibroproliferative responses to cutaneous injury. | Spatial and temporal localization of the melanocortin 1 receptor and its ligand α-melanocyte-stimulating hormone during cutaneous wound repair.
Muffley LA, Zhu KQ, Engrav LH, Gibran NS, Hocking AM., Free PMC Article | 04/30/2011 |