| Distribution and Localization of Mahogunin Ring Finger 1 in the Mouse Central Nervous System. | Distribution and Localization of Mahogunin Ring Finger 1 in the Mouse Central Nervous System.
Nakadate K, Kawakami K., Free PMC Article | 09/3/2022 |
| Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells. | Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.
Sirés-Campos J, Lambertos A, Delevoye C, Raposo G, Bennett DC, Sviderskaya E, Jiménez-Cervantes C, Olivares C, García-Borrón JC., Free PMC Article | 01/22/2022 |
| E3 ubiquitin-protein ligase MGRN1 (MGRN1) localizes to mitochondria, and mitochondria in cells from Mgrn1 null mutant mice display fragmentation and depolarization without recruitment of the parkin E3 ubiquitin ligase. The late onset of pathology in the brains of Mgrn1 null mutant mice suggests that a further, age-dependent effect on mitochondrial homeostasis is required to trigger vacuolation. | Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis.
Gunn TM, Silvius D, Lester A, Gibbs B., Free PMC Article | 06/20/2020 |
| Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system. | Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system.
Mukherjee R, Bhattacharya A, Sau A, Basu S, Chakrabarti S, Chakrabarti O. | 08/10/2019 |
| Mgrn1 can negatively regulate signaling through the Hedgehog pathway by reducing cell-surface and ciliary levels of Smoothened, an oncoprotein that transmits the Hedgehog signal across the membrane. | CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R., Free PMC Article | 01/30/2018 |
| With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1. | Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.
Benvegnù S, Mateo MI, Palomer E, Jurado-Arjona J, Dotti CG. | 09/9/2017 |
| Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase inclusions likely through autophagic pathway. | Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model.
Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A. | 10/22/2016 |
| Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. | Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
Srivastava D, Chakrabarti O., Free PMC Article | 10/25/2014 |
| This study indicates the mahogunin deficiency results in the infertility of male mice, disruption of hormones secretion and impaired active progressive motility. | The effect of mahogunin gene mutant on reproduction in male mice: a new sight for infertility?
Cheng D, Xiong C, Li J, Sui C, Wang S, Li H, Jiang X. | 10/4/2014 |
| ATRN also has no effect on prion disease onset or progression and discuss possible mechanisms that could cause vacuolation of the central nervous system in Mgrn1 and Atrn null mutant mice | RML prions act through Mahogunin and Attractin-independent pathways.
Gunn TM, Carlson GA., Free PMC Article | 06/14/2014 |
| pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4. | MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.
Gunn TM, Silvius D, Bagher P, Sun K, Walker KK., Free PMC Article | 09/28/2013 |
| Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. | Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease.
Silvius D, Pitstick R, Ahn M, Meishery D, Oehler A, Barsh GS, DeArmond SJ, Carlson GA, Gunn TM., Free PMC Article | 07/20/2013 |
| the md and mg mutations rescue the A(y) phenotypes by a primarily cAMP-independent mechanism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface. | Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.
Overton JD, Leibel RL., Free PMC Article | 07/30/2011 |
| study shows ASIP-MC1R signaling includes a cAMP-independent pathway through attractin and mahogunin, while the known cAMP-dependent component requires neither attractin nor mahogunin | Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway.
Hida T, Wakamatsu K, Sviderskaya EV, Donkin AJ, Montoliu L, Lynn Lamoreux M, Yu B, Millhauser GL, Ito S, Barsh GS, Jimbow K, Bennett DC., Free PMC Article | 01/21/2010 |
| data show that different Mgrn1 isoforms are not functionally equivalent in vivo and that the presence of only isoform I or III is sufficient for normal development, pigmentation, and neuronal integrity | Transgenic analysis of the physiological functions of Mahogunin Ring Finger-1 isoforms.
Jiao J, Kim HY, Liu RR, Hogan CA, Sun K, Tam LM, Gunn TM., Free PMC Article | 01/21/2010 |
| Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration. | Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.
Chakrabarti O, Hegde RS., Free PMC Article | 01/21/2010 |
| Loss of E3 ubiquitin ligase MGRN1 in mutant mice causes neurodegeneration via accumulation of its substrates. | Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice.
Sun K, Johnson BS, Gunn TM., Free PMC Article | 01/21/2010 |
| Mahoganoid mutation (Mgrn1md) on insulin sensitivity suggests that Mgrn1md may be increasing insulin sensitivity via the hypothalamic melanocortin-3 receptor pathway. | The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity.
Phan LK, Chung WK, Leibel RL. | 01/21/2010 |
| a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion diseases but without accumulation of protease-resistant prion protein | Spongiform degeneration in mahoganoid mutant mice.
He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS, Gunn TM. | 01/21/2010 |
| positional cloning of mahoganoid, encoding a novel 494-amino acid protein containing a C3HC4 RING (really interesting new gene) domain that may function as an E3 ubiquitin ligase | The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.
Phan LK, Lin F, LeDuc CA, Chung WK, Leibel RL., Free PMC Article | 01/21/2010 |
| Mgrn1 mutant embryos show abnormal expression of asymmetrically expressed genes involved in LR patterning. | Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis.
Cota CD, Bagher P, Pelc P, Smith CO, Bodner CR, Gunn TM. | 01/21/2010 |
| Our results indicate that reduced levels of MGRN1 cause the pigmentation phenotypes of Mgrn1 mutant mice and that there are no significant differences in the function of the four MGRN1 isoforms in pigment-type switching. | Characterization of Mahogunin Ring Finger-1 expression in mice.
Bagher P, Jiao J, Owen Smith C, Cota CD, Gunn TM. | 01/21/2010 |