| C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release. | C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release.
Krout M, Oh KH, Xiong A, Frankel EB, Kurshan PT, Kim H, Richmond JE., Free PMC Article | 05/25/2023 |
| The M domain in UNC-13 regulates the probability of neurotransmitter release. | The M domain in UNC-13 regulates the probability of neurotransmitter release.
Liu H, Li L, Sheoran S, Yu Y, Richmond JE, Xia J, Tang J, Liu J, Hu Z., Free PMC Article | 01/29/2022 |
| A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming. | A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.
Padmanarayana M, Liu H, Michelassi F, Li L, Betensky D, Dominguez MJ, Sutton RB, Hu Z, Dittman JS., Free PMC Article | 09/25/2021 |
| A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans. | A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans.
Li L, Liu H, Hall Q, Wang W, Yu Y, Kaplan JM, Hu Z., Free PMC Article | 09/19/2020 |
| Here the authors show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: forming C2A/C2A homodimers, or forming a heterodimer with the zinc finger domain of UNC-10/RIM (C2A/RIM). | Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans.
Liu H, Li L, Nedelcu D, Hall Q, Zhou L, Wang W, Yu Y, Kaplan JM, Hu Z., Free PMC Article | 04/4/2020 |
| cell-nonautonomous contributions of neuronal KGB-1 (and also in muscle) were effective in driving intestinal gene induction, age-dependent regulation of intestinal DAF-16, and stress resistance, and did not require KGB-1 expression in the target tissue. Additional genetic analyses revealed requirement for UNC-13 in mediating neuronal contributions, indicating involvement of neurotransmission. | Integration of Stress Signaling in Caenorhabditis elegans Through Cell-Nonautonomous Contributions of the JNK Homolog KGB-1.
Liu L, Ruediger C, Shapira M., Free PMC Article | 03/2/2019 |
| Thus, our study provides novel mechanistic insights into how Munc18/UNC-18 primes synaptic vesicle release and how this protein interacts functionally with Munc13/UNC-13 and Tomosyn/TOM-1. | UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.
Park S, Bin NR, Yu B, Wong R, Sitarska E, Sugita K, Ma K, Xu J, Tien CW, Algouneh A, Turlova E, Wang S, Siriya P, Shahid W, Kalia L, Feng ZP, Monnier PP, Sun HS, Zhen M, Gao S, Rizo J, Sugita S., Free PMC Article | 09/30/2017 |
| C1-C2B exerts a basal inhibition on Munc13 in the primed state, permitting calcium- and lipid-dependent control of C1-C2B to modulate synaptic strength | A C1-C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release.
Michelassi F, Liu H, Hu Z, Dittman JS., Free PMC Article | 09/16/2017 |
| Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder | Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.
Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I, van Teeseling HC, Evelein AM, Vorstman JA, Thoms S, Jahn O, Duran KJ, Monroe GR, Ryan TA, Taschenberger H, Dittman JS, Rhee JS, Visser G, Jans JJ, Brose N., Free PMC Article | 09/9/2017 |
| results suggest that UNC-13L, UNC-13S, and Tomosyn form a molecular code that dictates the timing of neurotransmitter release | UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans.
Hu Z, Tong XJ, Kaplan JM., Free PMC Article | 04/4/2015 |
| data reveal multiple roles of UNC-13 C2A domain, and suggest that spontaneous release and the fast phase of evoked release may involve a common pool of SVs at the active zone | Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics.
Zhou K, Stawicki TM, Goncharov A, Jin Y., Free PMC Article | 03/7/2015 |
| The regulation of aging by unc-13 and sbt-1 is temperature-dependent. And the alterations in reproduction capability and stress response may be associated with the formation of this temperature-dependent property | Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent.
He KW, Shen LL, Zhou WW, Wang DY., Free PMC Article | 03/8/2010 |
| Results support a model for docking in which UNC-13 converts syntaxin from the closed to the open state, and open syntaxin acts directly in docking vesicles to the plasma membrane. | Open syntaxin docks synaptic vesicles.
Hammarlund M, Palfreyman MT, Watanabe S, Olsen S, Jorgensen EM., Free PMC Article | 01/21/2010 |
| UNC-13 may regulate multiple steps of the synaptic-vesicle cycle, and its interaction with syntaxin is required for synaptic transmission. | UNC-13 interaction with syntaxin is required for synaptic transmission.
Madison JM, Nurrish S, Kaplan JM. | 01/21/2010 |
| Calcium activated protein for secretion (CAPS)/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system. | UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.
Speese S, Petrie M, Schuske K, Ailion M, Ann K, Iwasaki K, Jorgensen EM, Martin TF., Free PMC Article | 01/21/2010 |
| Even when inhibited synaptic vesicle priming is restored, synaptic transmission remains defective in unc-13 mutants, suggesting that UNC-13 is also required for other aspects of secretion. | Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.
McEwen JM, Madison JM, Dybbs M, Kaplan JM. | 01/21/2010 |
| This study investigates a role for UNC-13 in RNAi through analysis of RNAi penetrance in unc-13 and eri-1 mutant strains. UNC-13 functions in conjunction with ERI-1 in RNAi. | Synaptic neurotransmission protein UNC-13 affects RNA interference in neurons.
Chapin A, Correa P, Maguire M, Kohn R. | 01/21/2010 |