| Low-intensity noise exposure takes an essential part in the mechanism of late-onset hereditary hearing loss caused by Abcc1 mutation. | Low-intensity noise exposure takes an essential part in the mechanism of late-onset hereditary hearing loss caused by Abcc1 mutation.
Jiang M, Zhang S, Liu J, Pang B, Bai Y, Chen Y, Huang H, Ling J, Mei L. | 09/5/2024 |
| ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet in male mice. | ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet in male mice.
Villalobos E, Miguelez-Crespo A, Morgan RA, Ivatt L, Paul M, Simpson JP, Homer NZM, Kurian D, Aguilar J, Kline RA, Wishart TM, Morton NM, Stimson RH, Andrew R, Walker BR, Nixon M., Free PMC Article | 07/29/2024 |
| [Study on Down-regulation of Interleukin-1beta Secretion by Inhibiting ABCC1/MRP1 Transporter]. | [Study on Down-regulation of Interleukin-1β Secretion by Inhibiting ABCC1/MRP1 Transporter].
Chen YY, Ying PT, Weng WW, Fang MX, Li J, Luo ZB, Jia M, Guo XP, Zhang LY, Xu XJ, Tang YM. | 07/16/2024 |
| ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity. | ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity.
Liu J, Bai Y, Feng Y, Liu X, Pang B, Zhang S, Jiang M, Chen A, Huang H, Chen Y, Ling J, Mei L., Free PMC Article | 07/2/2024 |
| ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. | ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Maltbaek JH, Cambier S, Snyder JM, Stetson DB., Free PMC Article | 10/22/2022 |
| Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione. | Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
Gallman AE, Wolfreys FD, Nguyen DN, Sandy M, Xu Y, An J, Li Z, Marson A, Lu E, Cyster JG., Free PMC Article | 02/26/2022 |
| ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression. | ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression.
Chen L, Chen H, Xing Y, Li J. | 01/29/2022 |
| Infected Mrp1 knockout mice show decreased iNKT cell responses to antigens from Streptococcus pneumoniae and were associated with increased mortality. | Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
Chandra S, Gray J, Kiosses WB, Khurana A, Hitomi K, Crosby CM, Chawla A, Fu Z, Zhao M, Veerapen N, Richardson SK, Porcelli SA, Besra G, Howell AR, Sharma S, Peters B, Kronenberg M., Free PMC Article | 01/5/2019 |
| The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity. | Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.
Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA., Free PMC Article | 11/24/2018 |
| Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states. | Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts.
Zhang W, St Clair D, Butterfield A, Vore M., Free PMC Article | 01/27/2018 |
| Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia. | Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.
Bockor L, Bortolussi G, Vodret S, Iaconcig A, Jašprová J, Zelenka J, Vitek L, Tiribelli C, Muro AF. | 09/30/2017 |
| Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia. | Multidrug resistance associated protein-1 (MRP1) deficiency attenuates endothelial dysfunction in diabetes.
Neuser J, Fraccarollo D, Wick M, Bauersachs J, Widder JD. | 01/28/2017 |
| Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics. | Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells.
Gordillo GM, Biswas A, Khanna S, Spieldenner JM, Pan X, Sen CK., Free PMC Article | 11/12/2016 |
| P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier | Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.
Chapy H, Saubaméa B, Tournier N, Bourasset F, Behar-Cohen F, Declèves X, Scherrmann JM, Cisternino S., Free PMC Article | 11/5/2016 |
| Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 sertoli cell line. | Establishment of stable MRP1 knockdown by lentivirus-delivered shRNA in the mouse testis Sertoli TM4 cell line.
Li Z, Wang H, Huang S, Zhou L, Wang L, Du C, Wang C. | 01/16/2016 |
| neprilysin x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes | Accumulation of murine amyloid-β mimics early Alzheimer's disease.
Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen Und Halbach O, Pahnke J. | 10/17/2015 |
| Expression of apoA-I or ABCA1 can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis | Apolipoprotein A-I and adenosine triphosphate-binding cassette transporter A1 expression alleviates lipid accumulation in hepatocytes.
Liu W, Qin L, Yu H, Lv F, Wang Y. | 11/8/2014 |
| Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner. | LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner.
Sivils JC, Ancrum TM, Bain LJ., Free PMC Article | 02/8/2014 |
| Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells. | Metallothionein blocks oxidative DNA damage in vitro.
Qu W, Pi J, Waalkes MP., Free PMC Article | 07/6/2013 |
| These results identify Mrp1 as the transporter essential for S1P efflux from the endothelial cells and thus for inside-out S1P signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers. | Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers.
Cartwright TA, Campos CR, Cannon RE, Miller DS., Free PMC Article | 04/20/2013 |
| investigated changes in the expression and activity of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in highly purified lung dendritic cells during aging | Expression and function of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells from aging mice.
Inui N, Hasegawa H, Suda T, Nakamura Y, Watanabe H, Chida K. | 11/17/2012 |
| Data suggest glutathione offers neuroprotection against methylmercury toxicity in a manner dependent on MRP1-mediated efflux. | Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1.
Rush T, Liu X, Nowakowski AB, Petering DH, Lobner D. | 09/22/2012 |
| Results show that the presence of Mdr1a, Mdr1b (P-glycoprotein Pgp) and multidrug resistance-associated protein (MRP1) encoding genes in the olfactory mucosa of rat and mouse was confirmed by RT-PCR. | Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.
Molinas A, Sicard G, Jakob I., Free PMC Article | 09/22/2012 |
| Assessment of activity, exploratory behavior, and anxiety levels revealed behavioral alterations in Abcb1(0/0) and Abcc1 (0/0) mice, whereas Abcg2(0/0) mice were mostly unaffected. | ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.
Schumacher T, Krohn M, Hofrichter J, Lange C, Stenzel J, Steffen J, Dunkelmann T, Paarmann K, Fröhlich C, Uecker A, Plath AS, Sommer A, Brüning T, Heinze HJ, Pahnke J., Free PMC Article | 09/1/2012 |
| Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.( | Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.
ElAli A, Urrutia A, Rubio-Araiz A, Hernandez-Jimenez M, Colado MI, Doeppner TR, Hermann DM. | 08/18/2012 |