| Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation. | Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Huang N, Winans T, Wyman B, Oaks Z, Faludi T, Choudhary G, Lai ZW, Lewis J, Beckford M, Duarte M, Krakko D, Patel A, Park J, Caza T, Sadeghzadeh M, Morel L, Haas M, Middleton F, Banki K, Perl A., Free PMC Article | 03/28/2024 |
| Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE[-/-]mice. | Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE(-/-)mice.
Xiang P, Chen Q, Chen L, Lei J, Yuan Z, Hu H, Lu Y, Wang X, Wang T, Yu R, Zhang W, Zhang J, Yu C, Ma L., Free PMC Article | 10/2/2023 |
| Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation. | Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.
Chen Q, Liu L, Ni S., Free PMC Article | 02/14/2023 |
| Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease. | Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
Puris E, Saveleva L, de Sousa Maciel I, Kanninen KM, Auriola S, Fricker G., Free PMC Article | 01/28/2023 |
| SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation. | SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Eom J, Choi J, Suh SS, Seo JB., Free PMC Article | 01/11/2023 |
| Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling. | Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
Cheng WL, Chen YC, Li SJ, Lee TI, Lee TW, Higa S, Chung CC, Kao YH, Chen SA, Chen YJ. | 07/30/2022 |
| CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis. | CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.
Geng J, Chen R, Yang FF, Lin P, Zhu YM, Fu X, Wang K, Feng Z, Wu J, Zhang H, Li QJ, Chen ZN, Zhu P., Free PMC Article | 04/9/2022 |
| SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway. | SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway.
Wu F, Xiong G, Chen Z, Lei C, Liu Q, Bai Y., Free PMC Article | 01/29/2022 |
| Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2. | Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
Fitzgerald E, Roberts J, Tennant DA, Boardman JP, Drake AJ., Free PMC Article | 10/30/2021 |
| Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice. | Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.
Wuggenig P, Kaya B, Melhem H, Ayata CK, Swiss IBD Cohort Investigators, Hruz P, Sayan AE, Tsumura H, Ito M, Roux J, Niess JH., Free PMC Article | 06/19/2021 |
| This study reports the crystal structure of the murine CD98hc extracellular domain and a comprehensive comparison with its human ortholog, revealing only one conserved surface patch that is neither shielded by glycosylation nor by the cell membrane with an accessible surface area typical for an antibody epitope. | Structural differences between the ectodomains of murine and human CD98hc.
Deuschle FC, Schiefner A, Skerra A. | 05/23/2020 |
| Inhibition of the amino acid transporter CD98/LAT1 abrogated the leucine-driven mTORC1 activation and reduced natural killer cell effector function | Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells.
Almutairi SM, Ali AK, He W, Yang DS, Ghorbani P, Wang L, Fullerton MD, Lee SH., Free PMC Article | 12/14/2019 |
| SLC3A2 dermal fibroblast deletion induced major skin phenotypes resembling premature aging | Dermal Fibroblast SLC3A2 Deficiency Leads to Premature Aging and Loss of Epithelial Homeostasis.
Tissot FS, Estrach S, Boulter E, Cailleteau L, Tosello L, Seguin L, Pisano S, Audebert S, Croce O, Féral CC. | 09/14/2019 |
| Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway. | Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway.
Boulter E, Estrach S, Tissot FS, Hennrich ML, Tosello L, Cailleteau L, de la Ballina LR, Pisano S, Gavin AC, Féral CC., Free PMC Article | 12/22/2018 |
| Slc3a2 is required for branched-chain amino-acid-dependent maintenance of Treg cells. | Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.
Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K. | 06/23/2018 |
| CD98hc expression in vascular smooth muscle cells contributes to the formation of plaques that are morphologically more stable, and thereby protects against atherothrombosis. | CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis.
Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg MH, Boisvert WA., Free PMC Article | 11/4/2017 |
| These results demonstrate a novel fundamental role of LAT1 to support the protein expression of 4F2hc via a chaperone-like function in chorionic trophoblasts. | Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc.
Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y., Free PMC Article | 09/16/2017 |
| CD98 is required for endothelial cell growth. CD98-specific reagents could have a dual anticancer effect: directly by inhibiting tumor cell proliferation and indirectly by preventing tumor angiogenesis | Endothelial Cells Require CD98 for Efficient Angiogenesis-Brief Report.
Liao Z, Cantor JM., Free PMC Article | 06/24/2017 |
| Taken together, our data indicate that T cell-specific deletion of CD98hc can contribute to the prevention of GvHD development due to the attenuation of lymphocyte migration and by increasing the generation of Treg cells. | Impaired CD98 signaling protects against graft-versus-host disease by increasing regulatory T cells.
Nishio Y, Fujino M, Cai S, Kitajima Y, Saito T, Tsumura H, Ito M, Ito Y, Nagahara Y, Li XK. | 12/17/2016 |
| data establish CD98hc as a master protective gene at the cross-road of redox control and AA availability, making it a relevant therapeutic target in cancer. | Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability.
de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg MH, Palacín M, Féral CC., Free PMC Article | 11/12/2016 |
| ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion. | Ubiquitylation of CD98 limits cell proliferation and clonal expansion.
Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH., Free PMC Article | 09/10/2016 |
| CD98hc mediated this stiffness sensing by increasing Rho kinase (ROCK) activity. | CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction.
Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg MH, Féral CC., Free PMC Article | 03/7/2015 |
| Mice lacking CD98hc in B cells are protected from experimental autoimmune encephalomyelitis. | CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis.
Cantor JM., Free PMC Article | 11/22/2014 |
| CD98 heavy chain is crucial for T cell-mediated autoimmune colitis. CD98 heavy chain deficiency in T cells is involved in increasing induced regulatory T cells. | CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells.
Bhuyan ZA, Arimochi H, Nishida J, Kataoka K, Kurihara T, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Yasutomo K. | 04/26/2014 |
| The role of SLC3A2 in keratinocytes is not in cell adhesion but, instead, in cell proliferation and migration through modulating integrin signaling by the Src-RhoA pathway. | CD98hc (SLC3A2) regulation of skin homeostasis wanes with age.
Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, Féral CC., Free PMC Article | 04/13/2013 |