| Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival. | Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival.
Sabeh F, Li XY, Olson AW, Botvinick E, Kurup A, Gimenez LE, Cho JS, Weiss SJ., | 08/7/2024 |
| Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy. | Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy.
Li X, Cao Q, Xu C, Wang J, Pan T, Liu Q, Xie P, Hu Z. | 05/28/2024 |
| Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts. | Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts.
Yeung CC, Garva R, Pickard A, Lu Y, Mallikarjun V, Swift J, Taylor SH, Rai J, Eyre DR, Chaturvedi M, Itoh Y, Meng QJ, Mauch C, Zigrino P, Kadler KE. | 12/21/2023 |
| Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis. | Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis.
Xia XD, Gill G, Lin H, Roth DM, Gu HM, Wang XJ, Su FY, Alabi A, Alexiou M, Zhang Z, Wang GQ, Graf D, Zhang DW. | 09/20/2023 |
| MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism. | MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism.
Chu TL, Chen P, Yu AX, Kong M, Tan Z, Tsang KY, Zhou Z, Cheah KSE., Free PMC Article | 03/28/2023 |
| Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair. | Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair.
Kümper M, Zamek J, Steinkamp J, Pach E, Mauch C, Zigrino P. | 01/11/2023 |
| Loss of Endothelial Cell Matrix Metalloproteinase 14 Reduces Melanoma Growth and Metastasis by Increasing Tumor Vessel Stability. | Loss of Endothelial Cell Matrix Metalloproteinase 14 Reduces Melanoma Growth and Metastasis by Increasing Tumor Vessel Stability.
Kümper M, Hessenthaler S, Zamek J, Niland S, Pach E, Mauch C, Zigrino P. | 06/25/2022 |
| Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition. | Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
Hayun H, Arkadash V, Sananes A, Arbely E, Stepensky D, Papo N. | 05/28/2022 |
| Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension. | Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension.
Hanna A, Shinde AV, Li R, Alex L, Humeres C, Balasubramanian P, Frangogiannis NG., Free PMC Article | 01/22/2022 |
| Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth. | Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth.
Pach E, Kümper M, Fromme JE, Zamek J, Metzen F, Koch M, Mauch C, Zigrino P., Free PMC Article | 12/25/2021 |
| Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers. | Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
Matsuzaki T, Keene DR, Nishimoto E, Noda M., Free PMC Article | 09/18/2021 |
| Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis. | Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.
Esteban S, Clemente C, Koziol A, Gonzalo P, Rius C, Martínez F, Linares PM, Chaparro M, Urzainqui A, Andrés V, Seiki M, Gisbert JP, Arroyo AG., Free PMC Article | 07/31/2021 |
| MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus. | MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus.
Jiang Z, Zhou J, Qin X, Zheng H, Gao B, Liu X, Jin G, Zhou Z., Free PMC Article | 07/10/2021 |
| Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFbeta1 after myocardial infarction. | Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.
Alonso-Herranz L, Sahún-Español Á, Paredes A, Gonzalo P, Gkontra P, Núñez V, Clemente C, Cedenilla M, Villalba-Orero M, Inserte J, García-Dorado D, Arroyo AG, Ricote M., Free PMC Article | 05/15/2021 |
| Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis. | Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis.
Placido L, Romero Y, Maldonado M, Toscano-Marquez F, Ramírez R, Calyeca J, Mora AL, Selman M, Pardo A., Free PMC Article | 04/24/2021 |
| Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs. | Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs.
Chan ZC, Kwan HR, Wong YS, Jiang Z, Zhou Z, Tam KW, Chan YS, Chan CB, Lee CW., Free PMC Article | 04/3/2021 |
| mir-22-3p/KLF6/MMP14 axis in fibro-adipogenic progenitors regulates fatty infiltration in muscle degeneration. | mir-22-3p/KLF6/MMP14 axis in fibro-adipogenic progenitors regulates fatty infiltration in muscle degeneration.
Lin Y, Wen-Jie Z, Chang-Qing L, Sheng-Xiang A, Yue Z. | 03/13/2021 |
| Proteomics-Based Characterization of the Effects of MMP14 on the Protein Content of Exosomes from Corneal Fibroblasts. | Proteomics-Based Characterization of the Effects of MMP14 on the Protein Content of Exosomes from Corneal Fibroblasts.
Han KY, Chang JH, Azar DT. | 02/2/2021 |
| Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity. | Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity.
Li X, Zhao Y, Chen C, Yang L, Lee HH, Wang Z, Zhang N, Kolonin MG, An Z, Ge X, Scherer PE, Sun K., Free PMC Article | 08/22/2020 |
| In activated macrophages MT1-MMP is trafficked from the Golgi complex to the surface via late endosomes/lysosomes in a pathway regulated by VAMP7 and VAMP8. | Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface.
Röhl J, West ZE, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey DK, Semmler ABT, Murray RZ. | 07/18/2020 |
| Expression profiling revealed partial and dynamically changing EMT states, as well as a significantly up-regulated proteolytic signature, including many Mmp14. | MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.
Hillebrand LE, Wickberg SM, Gomez-Auli A, Follo M, Maurer J, Busch H, Boerries M, Reinheckel T. | 05/9/2020 |
| In adipose tissues of diabetic mice, the mRNA and protein expression of MMP14 increased while the mRNA and protein expression of CSE decreased. In CSE knockout mice, the mRNA and protein expression of MMP14 in adipose tissues increased. High glucose increased the expression of MMP14 in adipocytes and visceral adipose tissues through inhibiting the expression of CSE. | Reduced cystathionine-γ-lyase (CSE) expression is involved in high glucose induced MMP14 expression in adipocytes and adipose tissues.
Hu TX, Si YL, Ruan Y, Wang XJ, Yao JQ, Wang HL, Xu Y, Ni X, Tan QY, Wang J. | 04/25/2020 |
| It demonstrate that CRN2 increased the secretion of TIMP4 as well as the catalytic activity of MMP14. | CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Solga R, Behrens J, Ziemann A, Riou A, Berwanger C, Becker L, Garrett L, de Angelis MH, Fischer L, Coras R, Barkovits K, Marcus K, Mahabir E, Eichinger L, Schröder R, Noegel AA, Clemen CS, German Mouse Clinic Consortium. | 04/4/2020 |
| PROX1 is a transcriptional regulator of MMP14 | PROX1 is a transcriptional regulator of MMP14.
Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM., Free PMC Article | 10/19/2019 |
| cells other than osteoclasts can cause focal bone destruction in inflammatory bone disease and suggest that MMP14 is a key mediator conferring pathological bone-resorbing capacity on c-Fos-deficient Sh3bp2(knock in (KI)/KI) macrophages. | Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts.
Kittaka M, Mayahara K, Mukai T, Yoshimoto T, Yoshitaka T, Gorski JP, Ueki Y., Free PMC Article | 09/28/2019 |