| PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate. | PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate.
Xu J, Jiang Y, Sherrard R, Ikegami K, Conradt B., Free PMC Article | 10/10/2023 |
| Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 in Caenorhabditis elegans. | Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 in Caenorhabditis elegans.
Park Y, Gaddy M, Hyun M, Jones ME, Aslam HM, Lee MH., Free PMC Article | 02/15/2023 |
| Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans. | Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.
Xu Z, Zhao J, Hong M, Zeng C, Guang S, Shi Y., Free PMC Article | 12/25/2021 |
| A PUF-8/PUM2-mediated layer of post-transcriptional regulation links altered Mff translation to mitochondrial dynamics and mitophagy, thereby mediating age-related mitochondrial dysfunctions. | The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J., Free PMC Article | 06/29/2019 |
| Results reveal a role for the proteasome in chromosome tethering and identify PUF-8 as a regulator of proteasome activity during early meiosis. | PUF-8 facilitates homologous chromosome pairing by promoting proteasome activity during meiotic entry in C. elegans.
Kumar GA, Subramaniam K. | 05/26/2018 |
| Gld-1; puf-8 double-mutant germ cells begin to express the meiotic marker HIM-3, lose P granules, and form the sperm-specific membranous organelle, which are characteristics of developing spermatocytes. | PUF-8 Functions Redundantly with GLD-1 to Promote the Meiotic Progression of Spermatocytes in Caenorhabditis elegans.
Priti A, Subramaniam K., Free PMC Article | 05/14/2016 |
| PUF-8 negatively regulates RAS/MAPK signalling to promote differentiation of C. elegans germ cells. | PUF-8 negatively regulates RAS/MAPK signalling to promote differentiation of C. elegans germ cells.
Vaid S, Ariz M, Chaturbedi A, Kumar GA, Subramaniam K., Free PMC Article | 06/8/2013 |
| PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline.PUF proteins, in addition to their known cytoplasmic roles, participate in nuclear processing and/or export of mRNAs. | PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline.
Pushpa K, Kumar GA, Subramaniam K., Free PMC Article | 05/4/2013 |
| puf-8 likely inhibits the proliferative fate through negatively regulating GLP-1/Notch signaling or by functioning parallel to it. | PUF-8, a Pumilio homolog, inhibits the proliferative fate in the Caenorhabditis elegans germline.
Racher H, Hansen D., Free PMC Article | 03/23/2013 |
| PUF-8 binds in vitro to specific sequences within pal-1 3' UTR that are critical for post-transcriptional suppression in germline stem cells. | PUF-8 suppresses the somatic transcription factor PAL-1 expression in C. elegans germline stem cells.
Mainpal R, Priti A, Subramaniam K., Free PMC Article | 01/7/2012 |
| Results suggest that PUF-8 and MEX-3 contribute to germline stem cell maintenance by promoting mitotic proliferation rather than by blocking meiotic entry. | C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis.
Ariz M, Mainpal R, Subramaniam K., Free PMC Article | 01/21/2010 |
| PUF-8 is critical for the hermaphrodite sperm/oocyte switch. | Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins.
Bachorik JL, Kimble J., Free PMC Article | 01/21/2010 |
| in primary spermatocytes, puf-8 is required to maintain meiosis and prevent the return to mitosis | Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8.
Subramaniam K, Seydoux G. | 01/21/2010 |
| Puf-8 is a negative regulator of vulval development | Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development.
Walser CB, Battu G, Hoier EF, Hajnal A. | 01/21/2010 |