| The amount of UBXN-6 was markedly increased upon starvation, but not with the treatment of tunicamycin and rapamycin. The induction upon starvation is a unique characteristic for UBXN-6 among C-terminal cofactors of CDC-48. | Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans.
Mojumder S, Sawamura R, Murayama Y, Ogura T, Yamanaka K. | 11/2/2019 |
| A novel role for p97/CDC-48, whereby its role in protein degradation is integrated with its role in regulating expression of endoplasmic reticulum stress response genes. | Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.
Marza E, Taouji S, Barroso K, Raymond AA, Guignard L, Bonneu M, Pallares-Lupon N, Dupuy JW, Fernandez-Zapico ME, Rosenbaum J, Palladino F, Dupuy D, Chevet E., Free PMC Article | 12/12/2015 |
| In the presence of ATP, the N-D1 ring repeatedly rotates 23 degrees clockwise and resets relative to the D2 ring. | High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.
Noi K, Yamamoto D, Nishikori S, Arita-Morioka K, Kato T, Ando T, Ogura T. | 06/28/2014 |
| All six UBXN proteins directly interacted with CDC-48.1, and simultaneous knockdown of the expression of three genes, ubxn-1, ubxn-2 and ubxn-3, induced embryonic lethal and sterile phenotypes, but knockdown of either one or two did not. | Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.
Sasagawa Y, Yamanaka K, Saito-Sasagawa Y, Ogura T. | 07/16/2011 |
| Positive cooperativity of the p97 AAA ATPase is critical for essential functions. | Positive cooperativity of the p97 AAA ATPase is critical for essential functions.
Nishikori S, Esaki M, Yamanaka K, Sugimoto S, Ogura T., Free PMC Article | 07/2/2011 |
| The C. elegans p97/CDC-48-UFD-1-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation. | Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.
Sasagawa Y, Otani M, Higashitani N, Higashitani A, Sato K, Ogura T, Yamanaka K. | 01/21/2010 |
| ATX-3 interacts with both VCP/p97 worm homologs, CDC-48.1 and CDC-48.2 and the interaction domains were mapped. | ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
Rodrigues AJ, Neves-Carvalho A, Ferro A, Rokka A, Corthals G, Logarinho E, Maciel P. | 01/21/2010 |
| These findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability. | Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.
Mouysset J, Deichsel A, Moser S, Hoege C, Hyman AA, Gartner A, Hoppe T., Free PMC Article | 01/21/2010 |
| A novel signaling module involving CRP-1 and CDC-48 which may directly link the unfolded protein response to DNA remodeling and transcription control. | GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.
Caruso ME, Jenna S, Bouchecareilh M, Baillie DL, Boismenu D, Halawani D, Latterich M, Chevet E., Free PMC Article | 01/21/2010 |
| These results indicate that both HMG-12 and CAR-1 play important roles in embryonic expression of cdc-48.1. | Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.
Yamauchi S, Higashitani N, Otani M, Higashitani A, Ogura T, Yamanaka K. | 01/21/2010 |
| data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation | Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.
Ramadan K, Bruderer R, Spiga FM, Popp O, Baur T, Gotta M, Meyer HH. | 01/21/2010 |
| C. elegans p97 plays an important role in the progression of meiosis | Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.
Sasagawa Y, Yamanaka K, Nishikori S, Ogura T. | 01/21/2010 |