| Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome. | Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome.
Potter AS, Miyake CY, Gonzaga-Jauregui C, Aguilar-Sanchez Y, Hulsurkar MM, Lahiri SK, Moreira LM, Mehta N, Azamian MS, Lupski JR, Reilly S, Lalani SR, Wehrens XHT., | 10/1/2024 |
| The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1. | The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
Nørregaard KS, Jürgensen HJ, Ingvarsen SZ, Heltberg SS, Hagensen CE, Gårdsvoll H, Madsen DH, Jensen ON, Engelholm LH, Behrendt N. | 09/17/2022 |
| Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis. | Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.
Jungwirth U, van Weverwijk A, Evans RJ, Jenkins L, Vicente D, Alexander J, Gao Q, Haider S, Iravani M, Isacke CM., Free PMC Article | 07/3/2021 |
| MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/beta-catenin signaling pathway. | MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/β-catenin signaling pathway.
Li R, Ruan Q, Yin F, Zhao K. | 05/15/2021 |
| Fibroblast-specific expression of uPARAP governed endogenous SP-D levels and overall survival after lung injury. | Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.
Jürgensen HJ, Nørregaard KS, Sibree MM, Santoni-Rugiu E, Madsen DH, Wassilew K, Krustrup D, Garred P, Bugge TH, Engelholm LH, Behrendt N., Free PMC Article | 10/26/2019 |
| uPARAP controlVEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis. | uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
Durré T, Morfoisse F, Erpicum C, Ebroin M, Blacher S, García-Caballero M, Deroanne C, Louis T, Balsat C, Van de Velde M, Kaijalainen S, Kridelka F, Engelholm L, Struman I, Alitalo K, Behrendt N, Paupert J, Noel A., Free PMC Article | 02/9/2019 |
| Findings show that under in vivo conditions, uPARAP does not play a role in the phagocytic uptake of collagen fibrils by fibroblasts. | Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo Is Independent of the uPARAP/Endo180 Receptor.
Sprangers S, Behrendt N, Engelholm L, Cao Y, Everts V. | 12/2/2017 |
| Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma | Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
Engelholm LH, Melander MC, Hald A, Persson M, Madsen DH, Jürgensen HJ, Johansson K, Nielsen C, Nørregaard KS, Ingvarsen SZ, Kjaer A, Trovik CS, Laerum OD, Bugge TH, Eide J, Behrendt N. | 05/28/2016 |
| AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. | AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.
Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J. | 04/18/2015 |
| uPARAP function in cutaneous wound repair | uPARAP function in cutaneous wound repair.
Rohani MG, Chow YH, Razumova MV, Ash S, Hung CF, Schnapp LM., Free PMC Article | 01/17/2015 |
| Both uPARAP and MMP-2 take part in matrix turnover processes important for bone growth. | Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis.
Madsen DH, Jürgensen HJ, Ingvarsen S, Melander MC, Albrechtsen R, Hald A, Holmbeck K, Bugge TH, Behrendt N, Engelholm LH., Free PMC Article | 04/19/2014 |
| Genetic ablation of the Mrc2 impaired the intracellular collagen degradation pathway. | M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.
Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH., Free PMC Article | 11/16/2013 |
| This function of uPARAP/Endo180 defines a novel role of intracellular collagen turnover in fibrosis protection. | Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis.
Madsen DH, Jürgensen HJ, Ingvarsen S, Melander MC, Vainer B, Egerod KL, Hald A, Rønø B, Madsen CA, Bugge TH, Engelholm LH, Behrendt N. | 05/26/2012 |
| uPARAP is highly expressed in the murine lung, and loss of uPARAP leads to differences in lung mechanics, lung permeability, and collagen content after injury | Role of urokinase plasminogen activator receptor-associated protein in mouse lung.
Bundesmann MM, Wagner TE, Chow YH, Altemeier WA, Steinbach T, Schnapp LM., Free PMC Article | 03/31/2012 |
| data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway | Mannose receptor 2 attenuates renal fibrosis.
López-Guisa JM, Cai X, Collins SJ, Yamaguchi I, Okamura DM, Bugge TH, Isacke CM, Emson CL, Turner SM, Shankland SJ, Eddy AA., Free PMC Article | 03/31/2012 |
| A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. | A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
Jürgensen HJ, Madsen DH, Ingvarsen S, Melander MC, Gårdsvoll H, Patthy L, Engelholm LH, Behrendt N., Free PMC Article | 11/26/2011 |
| we demonstrate extensive uPARAP expression in the mesenchyme throughout murine lung development. | uPARAP expression during murine lung development.
Smith L, Wagner TE, Huizar I, Schnapp LM., Free PMC Article | 01/21/2010 |
| fibroblast-mediated collagen degradation proceeds preferentially as a sequential mechanism in which extracellular collagenolysis is followed by uPARAP/Endo180-mediated endocytosis of large collagen fragments. | Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.
Madsen DH, Engelholm LH, Ingvarsen S, Hillig T, Wagenaar-Miller RA, Kjøller L, Gårdsvoll H, Høyer-Hansen G, Holmbeck K, Bugge TH, Behrendt N. | 01/21/2010 |
| targeted deletion of Endo180 exons 2-6 results in cells that have a defect in collagen binding and internalization and an impaired migratory phenotype | A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.
East L, McCarthy A, Wienke D, Sturge J, Ashworth A, Isacke CM., Free PMC Article | 01/21/2010 |
| Deletion of uPARAP/Endo180 impaired collagen turnover critical to tumor expansion, as evidenced by abrogation of collagen uptake, tumor fibrosis, and blunted tumor growth. uPARAP/Endo180 mediates collagen turnover in a pathophysiological context. | Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo AA, Behrendt N, Nielsen BS, Bugge TH., Free PMC Article | 01/21/2010 |
| The mannose receptor is the main candidate for being the endocytic denatured collagen receptor on liver sinusoidal endothelial cells | The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor.
Malovic I, Sørensen KK, Elvevold KH, Nedredal GI, Paulsen S, Erofeev AV, Smedsrød BH, McCourt PA. | 01/21/2010 |