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    DMP1 dentin matrix acidic phosphoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 1758, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets.

    First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets.
    Bastida G, Ramírez F, Exeni G, Costa M, Ávila SA.

    03/27/2023
    Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets.

    Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets.
    Tavana N, Ting TH, Lai K, Kennerson ML, Thilakavathy K., Free PMC Article

    12/31/2022
    Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m(6)A modification.

    Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m(6)A modification.
    He Y, Wang W, Luo P, Wang Y, He Z, Dong W, Jia M, Yu X, Yang B, Wang J.

    10/22/2022
    DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration.

    DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration.
    Suzuki S, Yuan H, Hirata-Tsuchiya S, Yoshida K, Sato A, Nemoto E, Shiba H, Yamada S.

    07/17/2021
    dentin matrix protein 1 was detected in the periodontal ligament co-localized with periostin in the vicinity of the cement

    Periostin, dentin matrix protein 1 and P2rx7 ion channel in human teeth and periodontal ligament.
    Menéndez-Diaz I, Muriel JD, García-Suárez O, Obaya A, Cal S, Cobo J, Vega JA, Cobo T.

    09/1/2018
    The Dentin matrix protein1 (Dmp1) is an acidic phosphoprotein of osteocytes proposed to participate in bone and dentin mineralization.

    In focus in HCB.
    Taatjes DJ, Roth J.

    07/14/2018
    Thus, unspDMP-1 is a novel chromatin-enriched RNA that epigenetically regulates cellular proliferation of SQCC.

    Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.
    Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H.

    02/17/2018
    DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients.

    Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients.
    Yoon CY, Park J, Seo C, Nam BY, Kim S, Kee YK, Lee M, Cha MU, Kim H, Park S, Yun HR, Jung SY, Jhee JH, Kwon YE, Wu M, Um JE, Kang HY, Park JT, Han SH, Kang SW, Kim HC, Park S, Lim SK, Yoo TH.

    12/23/2017
    DMP1 gene seems to be involved in genetic predisposition to Ankylosing spondylitis (AS).

    Association Between Dentin Matrix Protein 1 (rs10019009) Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province.
    Liu JM, Cui YZ, Zhang GL, Zhou XY, Pang JX, Wang XZ, Han JX., Free PMC Article

    02/4/2017
    DMP-1 immunostaining was higher for MTA and PC, confirming the reparative and bioinductive capacity of these materials.

    Immunolocalization of dentin matrix protein-1 in human primary teeth treated with different pulp capping materials.
    Lourenço Neto N, Marques NC, Fernandes AP, Rodini CO, Sakai VT, Abdo RC, Machado MA, Santos CF, Oliveira TM.

    09/24/2016
    This review will focus on the aberrant splicing of tumor suppressor/oncogenes that belong to the DMP1-ARF-MDM2-p53 pathway

    Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer.
    Inoue K, Fry EA., Free PMC Article

    08/27/2016
    Expressions of dentin matrix protein (DMP)-1 and osteopontin (OPN) were observed in both normal dentin and dentin from DGI-I affected patients, without significant differences

    Immunocytochemical detection of dentin matrix proteins in primary teeth from patients with dentinogenesis imperfecta associated with osteogenesis imperfecta.
    Orsini G, Majorana A, Mazzoni A, Putignano A, Falconi M, Polimeni A, Breschi L., Free PMC Article

    09/26/2015
    identify alternative splicing as a mechanism utilized by cancer cells to modulate the DMP1 locus through diminishing DMP1alpha tumour suppressor expression

    DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer.
    Maglic D, Stovall DB, Cline JM, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K., Free PMC Article

    07/25/2015
    The findings indicate that DMP-1 is a useful marker of osteogenic differentiation and mineralisation in soft tissue tumours

    Dentine matrix protein 1 (DMP-1) is a marker of bone formation and mineralisation in soft tissue tumours.
    Inagaki Y, Kashima TG, Hookway ES, Tanaka Y, Hassan AB, Oppermann U, Athanasou NA.

    06/20/2015
    A family of autosomal recessive form of Hypophosphatemic rickets secondary to a DMP1 mutation located in the first coding exon of the gene, is reported.

    Exome sequencing reveals a mutation in DMP1 in a family with familial sclerosing bone dysplasia.
    Gannagé-Yared MH, Makrythanasis P, Chouery E, Sobacchi C, Mehawej C, Santoni FA, Guipponi M, Antonarakis SE, Hamamy H, Mégarbané A.

    06/20/2015
    Results suggest that FAM20C suppresses FGF23 production by enhancing DMP1 expression, and inactivating mutations in FAM20C cause FGF23-related hypophosphatemia by decreasing transcription of DMP1.

    Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia.
    Kinoshita Y, Hori M, Taguchi M, Fukumoto S.

    05/16/2015
    DMP1 may play an important role in maintaining the chondrogenic phenotype and its possible involvement in altered cartilage matrix remodelling and degradation in disease conditions like osteoarthritis.

    Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis.
    Prasadam I, Zhou Y, Shi W, Crawford R, Xiao Y.

    01/31/2015
    DMP1 and DSPP were more abundant in carious than in sound samples.

    Dentin matrix protein 1 and dentin sialophosphoprotein in human sound and carious teeth: an immunohistochemical and colorimetric assay.
    Martini D, Trirè A, Breschi L, Mazzoni A, Teti G, Falconi M, Ruggeri A Jr., Free PMC Article

    10/25/2014
    DMP-1 is a matrix marker expressed around osteocytes in human woven and lamellar bone and is useful in identifying osteosarcoma and other bone-forming tumours.

    Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours.
    Kashima TG, Dongre A, Oppermann U, Athanasou NA.

    06/29/2013
    Mutations in PHEX and DMP1 play a role in causing hypophosphatemic rickets.

    Mutational analysis of PHEX, FGF23, DMP1, SLC34A3 and CLCN5 in patients with hypophosphatemic rickets.
    Beck-Nielsen SS, Brixen K, Gram J, Brusgaard K.

    12/8/2012
    DMP1 is regulated post-transcriptionally by let-7 during odontoblast differentiation.

    DMP1 is a target of let-7 in dental pulp cells.
    Yue J, Wu B, Gao J, Huang X, Li C, Ma D, Fang F.

    10/20/2012
    DMP-1 stimulated production of IL-6/IL-8 from pulp fibroblasts. Inhibition of p38 mitogen-activated protein kinase pathway blocked proinflammatory effect on pulp fibroblasts. DMP-1 might participate in development of inflammatory changes in pulp.

    Dentin matrix protein-1 activates dental pulp fibroblasts.
    Abd-Elmeguid A, Yu DC, Kline LW, Moqbel R, Vliagoftis H.

    06/2/2012
    Simvastatin plus all-trans retinoic acid reduces expression of WT1 and DMP1 in the promyelocytic leukemia cell line NB4.

    [Effects of simvastatin plus all-trans retinoic acid on WT1/hDMP1 gene expression profiles of human promyelocytic leukemia cell line NB4].
    Jiang TX, Gu WY, Qiu GQ, Chen ZX, Wang ZL, Wu HQ, Hua XY, He B, Wu W, Xie XB, Cao XS.

    04/28/2012
    DMP1 is specifically involved in signaling via extracellular matrix-cell surface interaction.

    Dentin matrix protein 1 (DMP1) signals via cell surface integrin.
    Wu H, Teng PN, Jayaraman T, Onishi S, Li J, Bannon L, Huang H, Close J, Sfeir C., Free PMC Article

    10/22/2011
    Data show the wide spectrum of genetic variation that can be seen in PHEX, FGF23 and DMP1 when screening a large cohort with hypophosphatemic rickets.

    Mutational analysis of PHEX, FGF23 and DMP1 in a cohort of patients with hypophosphatemic rickets.
    Ruppe MD, Brosnan PG, Au KS, Tran PX, Dominguez BW, Northrup H., Free PMC Article

    06/18/2011
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