| Cited2 is a key regulator of placental development and plasticity. | Cited2 is a key regulator of placental development and plasticity.
Kuna M, Soares MJ., | 08/22/2024 |
| Gut microbiota-induced microRNA-206-3p increases anxiety-like behaviors by inhibiting expression of Cited2 and STK39. | Gut microbiota-induced microRNA-206-3p increases anxiety-like behaviors by inhibiting expression of Cited2 and STK39.
Li Q, Zhang J, Gao Z, Zhang Y, Gu J. | 03/3/2023 |
| Pathophysiological Role of Variants of the Promoter Region of CITED2 Gene in Sporadic Tetralogy of Fallot Patients with Cellular Function Verification. | Pathophysiological Role of Variants of the Promoter Region of CITED2 Gene in Sporadic Tetralogy of Fallot Patients with Cellular Function Verification.
Chen Z, Chen HX, Hou HT, Yin XY, Yang Q, He GW., Free PMC Article | 11/19/2022 |
| CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation. | CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation.
Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C, Georges E, Martins-Costa C, Sepulveda C, Allen L, Campos J, Campbell KJ, O'Carroll D, Göttgens B, Cory S, Rodrigues NP, Guitart AV, Kranc KR., Free PMC Article | 03/19/2022 |
| The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells. | The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells.
Kunkemoeller B, Chen K, Lockhart SM, Wang X, Rask-Madsen C., Free PMC Article | 09/25/2021 |
| CITED2 inhibits STAT1-IRF1 signaling and atherogenesis. | CITED2 inhibits STAT1-IRF1 signaling and atherogenesis.
Zafar A, Pong Ng H, Diamond-Zaluski R, Kim GD, Ricky Chan E, Dunwoodie SL, Smith JD, Mahabeleshwar GH., Free PMC Article | 08/28/2021 |
| Atypical Neocortical Development in the Cited2 Conditional Knockout Leads to Behavioral Deficits Associated with Neurodevelopmental Disorders. | Atypical Neocortical Development in the Cited2 Conditional Knockout Leads to Behavioral Deficits Associated with Neurodevelopmental Disorders.
Wagner NR, MacDonald JL. | 05/15/2021 |
| CITED2 limits pathogenic inflammatory gene programs in myeloid cells. | CITED2 limits pathogenic inflammatory gene programs in myeloid cells.
Pong Ng H, Kim GD, Ricky Chan E, Dunwoodie SL, Mahabeleshwar GH., Free PMC Article | 03/13/2021 |
| Cited2 plays an important role in cell cycle progression and in maintaining the balance between cardiac stem cells proliferation and apoptosis in the process of aging without influencing cell fate decisions. | Cited2 regulates proliferation and survival in young and old mouse cardiac stem cells.
Wu Q, Liu Q, Zhan J, Wang Q, Zhang D, He S, Pu S, Zhou Z., Free PMC Article | 03/14/2020 |
| These findings illustrate that combined PU.1/CITED2 deregulation induces a transcriptional program that promotes HSPC maintenance, which might be a prerequisite for malignant transformation. | Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells.
Mattes K, Geugien M, Korthuis PM, Brouwers-Vos AZ, Fehrmann RSN, Todorova TI, Steidl U, Vellenga E, Schepers H. | 02/22/2020 |
| current data suggest that CITED2 is a critical regulator in physiologic loading-induced chondroprotection in the context of a hight fat diet and PGC-1alpha is required for the inhibitory effects of CITED2 on the expression of adipokines such as adipsin and adiponectin in the infrapatellar fat pad | CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad.
Liu L, He Z, Xu L, Lu L, Feng H, Leong DJ, Kim SJ, Hirsh DM, Majeska RJ, Goldring MB, Cobelli NJ, Sun HB. | 02/15/2020 |
| E2F1 and E2F4 regulated Cited2 expression in neurons after stroke-related insults. Taken together, these results indicate that the E2F-Cited2 regulatory pathway is critically involved in stroke injury. | The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors.
Huang T, González YR, Qu D, Huang E, Safarpour F, Wang E, Joselin A, Im DS, Callaghan SM, Boonying W, Julian L, Dunwoodie SL, Slack RS, Park DS., Free PMC Article | 12/14/2019 |
| Observations identify CITED2 as a novel negative regulator of macrophage proinflammatory activation that protects the host from inflammatory insults. | CITED2 Restrains Proinflammatory Macrophage Activation and Response.
Kim GD, Das R, Rao X, Zhong J, Deiuliis JA, Ramirez-Bergeron DL, Rajagopalan S, Mahabeleshwar GH., Free PMC Article | 04/6/2019 |
| Knockdown of CITED2 led to a decreased interaction of p53 with its inhibitor MDM2, which results in increased amounts of total p53 protein. Data indicate that CITED2 functions in pathways regulating p53 activity. | CITED2 affects leukemic cell survival by interfering with p53 activation.
Mattes K, Berger G, Geugien M, Vellenga E, Schepers H., Free PMC Article | 07/7/2018 |
| Data suggest that tumor suppressor gene Cited2 is direct target of microRNA-182-5p; here, carcinogenic solvent trichloroethylene (TCE) up-regulates expression of microRNA-182-5p in liver; TCE-induced hepatocyte cell proliferation is mediated by microRNA-182-5p overexpression and down-regulation of Cited2 expression. | The Role of miR-182-5p in Hepatocarcinogenesis of Trichloroethylene in Mice.
Jiang Y, Chen J, Yue C, Zhang H, Tong J, Li J, Chen T. | 03/10/2018 |
| CITED2 and ISL1 proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes. | CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells.
Pacheco-Leyva I, Matias AC, Oliveira DV, Santos JM, Nascimento R, Guerreiro E, Michell AC, van De Vrugt AM, Machado-Oliveira G, Ferreira G, Domian I, Bragança J., Free PMC Article | 11/18/2017 |
| ectopic CITED2 expression at the onset of the reprogramming process in combination with the reprogramming factors promotes a complete and homogeneous conversion of somatic cells into induced pluripotent stem cells | Ectopic expression of CITED2 prior to reprogramming, promotes and homogenises the conversion of somatic cells into induced pluripotent stem cells.
Charneca J, Matias AC, Escapa AL, Fernandes C, Alves A, Santos JMA, Nascimento R, Bragança J. | 10/21/2017 |
| This study demonstrated that Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity in mice. | Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.
Fame RM, MacDonald JL, Dunwoodie SL, Takahashi E, Macklis JD., Free PMC Article | 07/15/2017 |
| Study showed a novel function of miR-200b and CITED2 in high glucose-induced unfolded protein response and ER stress, suggesting that miR-200b and CITED2 are critical for ER homeostasis and neural tube defect formation in the developing embryo. | High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress.
Gu H, Yu J, Dong D, Zhou Q, Wang JY, Fang S, Yang P., Free PMC Article | 04/30/2016 |
| MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2. | MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.
Clark AL, Naya FJ., Free PMC Article | 12/19/2015 |
| Cited2 is required for and enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. | Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells.
Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Catarina Matias A, Luisa Escapa A, Subramani C, Wheadon H, Trindade M, Nichols J, Kaji K, Enver T, Bragança J., Free PMC Article | 12/5/2015 |
| Cited2 is required for the maintenance of adult hematopoietic stem cell glycolytic metabolism likely through regulating Pdk2, Pdk4, lactate dehydrogenases B and D, and Akt activity. | Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells.
Du J, Li Q, Tang F, Puchowitz MA, Fujioka H, Dunwoodie SL, Danielpour D, Yang YC., Free PMC Article | 08/30/2014 |
| Cited2 in sinusoidal trophoblast giant cells and syncytiotrophoblasts is likely to have a non-cell autonomous role in patterning of the pericytes associated with the embryonic capillaries. | Cited2 is required in trophoblasts for correct placental capillary patterning.
Moreau JL, Artap ST, Shi H, Chapman G, Leone G, Sparrow DB, Dunwoodie SL. | 08/16/2014 |
| a deletion of Cited2 in mESCs results in abnormal mitochondrial morphology and impaired glucose metabolism, which correlates with a defective cell fate decision. | Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells.
Li Q, Hakimi P, Liu X, Yu WM, Ye F, Fujioka H, Raza S, Shankar E, Tang F, Dunwoodie SL, Danielpour D, Hoppel CL, Ramírez-Bergeron DL, Qu CK, Hanson RW, Yang YC., Free PMC Article | 03/22/2014 |
| CITED2 is phosphorylated by MAPK1 in vitro at T166, and that MAPK1 activation enhances the coactivation function of CITED2 but not of CITED2-T166N. | Functional significance of SRJ domain mutations in CITED2.
Chen CM, Bentham J, Cosgrove C, Braganca J, Cuenda A, Bamforth SD, Schneider JE, Watkins H, Keavney B, Davies B, Bhattacharya S., Free PMC Article | 04/13/2013 |