| A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. | A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
Stabach PR, Sims D, Gomez-Bañuelos E, Zehentmeier S, Dammen-Brower K, Bernhisel A, Kujawski S, Lopez SG, Petri M, Goldman DW, Lester ER, Le Q, Ishaq T, Kim H, Srivastava S, Kumar D, Pereira JP, Yarema KJ, Koumpouras F, Andrade F, Braddock DT., Free PMC Article | 09/20/2024 |
| The protective effect of DNase I in retinal vein occlusion. | The protective effect of DNase I in retinal vein occlusion.
Deng G, Zou X, Liu Z, Ren H, Li Y, Chen B, Zhang J., Free PMC Article | 03/15/2024 |
| Significant Association of DNASE1 Variable Number Tandem Repeats and Single Nucleotide Polymorphisms With Gastric Cancer. | Significant Association of DNASE1 Variable Number Tandem Repeats and Single Nucleotide Polymorphisms With Gastric Cancer.
Kafil A, Mohamadynejad P, Moghanibashi M., Free PMC Article | 08/27/2022 |
| Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction. | Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction.
Hofbauer TM, Mangold A, Ondracek AS, Panzenböck A, Scherz T, Müller J, Distelmaier K, Seidl V, Kastl S, Müller-Nurasyid M, Peters A, Strauch K, Winker R, Wohlschläger-Krenn E, Nistler S, Lang IM., Free PMC Article | 12/11/2021 |
| AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response. | AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response.
Xia Y, He J, Zhang H, Wang H, Tetz G, Maguire CA, Wang Y, Onuma A, Genkin D, Tetz V, Stepanov A, Terekhov S, Ukrainskaya V, Huang H, Tsung A., Free PMC Article | 11/13/2021 |
| The Nexus of cfDNA and Nuclease Biology. | The Nexus of cfDNA and Nuclease Biology.
Han DSC, Lo YMD. | 09/11/2021 |
| Evaluation of the functional effects of genetic variantsmissense and nonsense SNPs, indels and copy number variationsin the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity. | Evaluation of the functional effects of genetic variants‒missense and nonsense SNPs, indels and copy number variations‒in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity.
Ueki M, Kimura-Kataoka K, Fujihara J, Iida R, Kawai Y, Kusaka A, Sasaki T, Takeshita H, Yasuda T., Free PMC Article | 10/31/2020 |
| Human deoxyribonuclease I (DNaseI) is overexpressed and encapsidated in hepatitis B virus (HBV) particles in vitro in hypoxic environments and in vivo in cirrhotic patient livers as well as in the serum of infected patients. DNase I induces genome-free hepatitis B virions and is incorporated into hepatitis B viral capsids. A hypoxic environment enhances DNASE1 and restricts HBV. | Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.
Hallez C, Li X, Suspène R, Thiers V, Bouzidi MS, M Dorobantu C, Lucansky V, Wain-Hobson S, Gaudin R, Vartanian JP. | 09/14/2019 |
| Cigarette smoke significantly increases the expression of neutrophil and macrophage extracellular traps with coexpression of the pathogenic proteases, neutrophil elastase and matrix metalloproteinases 9 and 12. This response to cigarette smoke was significantly reduced by the addition of DNase 1, which also significantly decreased macrophage numbers and lung proteolysis. | Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung.
King PT, Sharma R, O'Sullivan KM, Callaghan J, Dousha L, Thomas B, Ruwanpura S, Lim S, Farmer MW, Jennings BR, Finsterbusch M, Brooks G, Selemidis S, Anderson GP, Holdsworth SR, Bardin PG., Free PMC Article | 07/20/2019 |
| EndoG is an endonuclease with the unique ability to inactivate another endonuclease, DNase I, and to modulate the development of apoptosis. | Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4(+) T lymphocytes and prevents the progression of apoptosis.
Zhdanov DD, Gladilina YA, Pokrovsky VS, Grishin DV, Grachev VA, Orlova VS, Pokrovskaya MV, Alexandrova SS, Plyasova AA, Sokolov NN. | 03/2/2019 |
| Genetic variants in DNase I hypersensitive sites play an important role in carcinogenesis. two novel single nucleotide polymorphisms rs12309362 (odds ratio = 0.64, P = 5.61 x 10(-6) ) and rs9970827 (odds ratio = 0.73, P = 7.23 x 10(-6) ) significantly associated with decreased risk of HCC. | Systematical analyses of variants in DNase I hypersensitive sites to identify hepatocellular carcinoma susceptibility loci in a Chinese population.
Jiang T, Du F, Qin N, Lu Q, Dai J, Shen H, Hu Z. | 03/3/2018 |
| Serum DNase1-activity is significantly decreased in ALD patients, indicating its potential implication in their pathogenesis. Furthermore, DNase1-activity could be used as a new surrogate biomarker for predicting response to AIH treatment. | Decreased serum DNase1-activity in patients with autoimmune liver diseases.
Gatselis NK, Vakrakou AG, Zachou K, Androutsakos T, Azariadis K, Hatzis G, Manoussakis MN, Dalekos GN. | 12/23/2017 |
| Although no significant association between Q222R polymorphism in DNAse I gene and the risk of systemic lupus erythematosus was found, the presence of the A allele was associated with an increased risk for the development of nephropathy | Association between severe disease course and nephritis with Q222R polymorphism in DNAse I gene among lupus patients: An Argentine multicenter study.
Camicia G, Muñoz SA, Allievi A, Orden AO, Perés Wingeyer S, Trobo R, Eimon A, Barreira JC, Schneeberger E, Sarano J, Hofman J, de Larrañaga G, Aranda F. | 09/16/2017 |
| DNase I activity was observed to be increased in type 2 diabetes, and high glucose combined with increased DNase I is suggested to aggravate beta-cell apoptosis. | DNase I aggravates islet β-cell apoptosis in type 2 diabetes.
Zhu B, Zhang L, Zhang YY, Wang L, Li XG, Liu T, Fu YK, Zheng YF, Li P, Zhao ZG., Free PMC Article | 04/8/2017 |
| Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed. | Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.
Fujihara J, Ueki M, Kimura-Kataoka K, Iida R, Takeshita H, Yasuda T. | 04/1/2017 |
| in Iranians the 3/6 genotype frequency was significantly higher in systemic lupus erythematosus patients than in healthy controls which implies the possible role of this genotype in SLE susceptibility; the 3/4 and 4/6 genotype frequencies were remarkably high in the control group which indicated the protective role of these genotypes against the disease | Deoxyribonuclease I gene polymorphism and susceptibility to systemic lupus erythematosus.
Mohammadoo-Khorasani M, Musavi M, Mousavi M, Moossavi M, Khoddamian M, Sandoughi M, Zakeri Z. | 10/8/2016 |
| TNF-alpha amplifies DNaseI expression in renal tubular cells while IL-1beta promotes nuclear DNaseI translocation in inactive form in lupus nephritis. | TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form.
Thiyagarajan D, Rekvig OP, Seredkina N., Free PMC Article | 05/14/2016 |
| HumDN1 polymorphisms were examined in blood of 11 worldwide populations by polymerase chain reaction. 15 genotypes were found leading to the conclusion that HumDN1 variable no. tandem repeats are ethnic group specific. | Global analysis of genetic variations in a 56-bp variable number of tandem repeat polymorphisms within the human deoxyribonuclease I gene.
Fujihara J, Yasuda T, Iida R, Ueki M, Sano R, Kominato Y, Inoue K, Kimura-Kataoka K, Takeshita H. | 03/26/2016 |
| Val66Met in the BDNF gene and two SNPs, Fokl and Apal, in the VDR gene may potentially be associated with DED. Additionally, the association between DED and Val66Met may vary by depression status. | Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study.
Hallak JA, Tibrewal S, Mohindra N, Gao X, Jain S., Free PMC Article | 01/16/2016 |
| In conclusion, elevated DNase I in diabetes may be related to pancreatic injury and could be one of the causes that induce diabetes. | Increased DNase I activity in diabetes might be associated with injury of pancreas.
Zhu B, Gong Y, Chen P, Zhang H, Zhao T, Li P. | 02/14/2015 |
| Our results indicate that increased DNASE1 expression is common to both SLE and RA, while DNase1 reduction activity is specific to SLE. | Influence of HumDN1 VNTR polymorphism on DNASE1 expression in systemic lupus erythematosus and rheumatoid arthritis.
AlFadhli S, Ghanem AA. | 01/10/2015 |
| Characterization of the nonsynonymous single-nucleotide polymorphism variants of human DNASE1. | Identification of the functional alleles of the nonsynonymous single-nucleotide polymorphisms potentially implicated in systemic lupus erythematosus in the human deoxyribonuclease I gene.
Kimura-Kataoka K, Ueki M, Takeshita H, Fujihara J, Iida R, Kawai Y, Yasuda T., Free PMC Article | 09/27/2014 |
| DNase I activity in systemic lupus erythematosus patients was lower than in healthy controls | Serum DNase I activity in systemic lupus erythematosus: correlation with immunoserological markers, the disease activity and organ involvement.
Skiljevic D, Jeremic I, Nikolic M, Andrejevic S, Sefik-Bukilica M, Stojimirovic B, Bonaci-Nikolic B. | 05/3/2014 |
| DNAse I Q222R polymorphism is a potential genetic risk factor for systemic lupus erythematosus in South Indian Tamils. In addition, the mutant allele confers a significant risk for lupus nephritis. | Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patients.
Panneer D, Antony PT, Negi VS. | 04/26/2014 |
| Single nucleotide polymorphisms in the DNASE1 is associated with autoimmune diseases. | Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity.
Ueki M, Kimura-Kataoka K, Takeshita H, Fujihara J, Iida R, Sano R, Nakajima T, Kominato Y, Kawai Y, Yasuda T. | 03/8/2014 |