| Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess. | Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.
Gudekar N, Shanbhag V, Wang Y, Ralle M, Weisman GA, Petris MJ., Free PMC Article | 12/5/2020 |
| Cardiac-specific overexpression of metallothionein attenuates L-NAME-induced myocardial contractile anomalies and apoptosis. | Cardiac-specific overexpression of metallothionein attenuates L-NAME-induced myocardial contractile anomalies and apoptosis.
Yang L, Ma J, Tan Y, Zheng Q, Dong M, Guo W, Xiong L, Yang J, Ren J., Free PMC Article | 08/13/2020 |
| Cuprizone-induced demyelination is followed by high upregulation of MT-I/II and megalin immunoreactivity in astrocytes and epithelial and endothelial cells located in cerebral and cerebellar white and gray matter, as well as in choroid plexus and in numerous constituents of the neurogenic niches in subgranular zone (SGZ) of DG and in SVZ of lateral ventricles. | Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination.
Jakovac H, Grubić Kezele T, Radošević-Stašić B. | 03/30/2019 |
| these results demonstrate that MT2 plays a role in CD4+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function | Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation.
Rice JM, Zweifach A, Lynes MA., Free PMC Article | 10/14/2017 |
| blockade of metallothioneins 1 and 2 constitutes a promising approach for the treatment of conditions which result in muscle atrophy. | Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.
Summermatter S, Bouzan A, Pierrel E, Melly S, Stauffer D, Gutzwiller S, Nolin E, Dornelas C, Fryer C, Leighton-Davies J, Glass DJ, Fournier B., Free PMC Article | 07/15/2017 |
| Cardioprotective effects of MT1/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling. | Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice.
Duerr GD, Dewald D, Schmitz EJ, Verfuerth L, Keppel K, Peigney C, Ghanem A, Welz A, Dewald O., Free PMC Article | 05/20/2017 |
| Metallothioneins may have a protective role against post-burn inflammation and inflammatory organ damage, at least partly through inhibiting the p38 MAPK signaling. | Role of Metallothionein in Post-Burn Inflammation.
Zhang W, Xie Y, Liu W, Xu X, Chen X, Liu H, Liu Y. | 01/14/2017 |
| Enhanced senescence due to absence of metallothionein genes may shorten lifespan. | Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain.
Kadota Y, Aki Y, Toriuchi Y, Mizuno Y, Kawakami T, Sato M, Suzuki S. | 01/23/2016 |
| The MT2 receptor activates Akt/GSK-3beta/CRMP-2 signaling and is necessary and sufficient to mediate functional axonogenesis and synaptic formation in central neurons. | The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling.
Liu D, Wei N, Man HY, Lu Y, Zhu LQ, Wang JZ., Free PMC Article | 11/28/2015 |
| MT1/2 deficiency aggravated depleted uruanium-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression. | Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity.
Hao Y, Huang J, Gu Y, Liu C, Li H, Liu J, Ren J, Yang Z, Peng S, Wang W, Li R. | 11/21/2015 |
| Zinc-binding MT1 and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4. | Zinc-binding metallothioneins are key modulators of IL-4 production by basophils.
Ugajin T, Nishida K, Yamasaki S, Suzuki J, Mita M, Kubo M, Yokozeki H, Hirano T. | 08/15/2015 |
| Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure | Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure.
Qu W, Waalkes MP., Free PMC Article | 03/21/2015 |
| the metal binding abilities of mouse MT2 (mMT2) with divalent (Zn(II) and Cd(II)) and monovalent (Cu(I)) ions were analyzed and compared to those of the mouse MT1 (mMT1) isoform. | Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities.
Artells E, Palacios Ò, Capdevila M, Atrian S. | 05/24/2014 |
| The results of this study suggest that metallothioneins may play a key role in protecting the kidney against high glucose-induced ROS and subsequent inflammation in diabetic nephropathy. | Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice.
Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horiguchi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H. | 03/1/2014 |
| these results demonstrate that MT-I/II knockout mice are more vulnerable to cadmium-induced fetal growth retardation. | Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction.
Selvaratnam J, Guan H, Koropatnick J, Yang K. | 11/16/2013 |
| These data indicate that metallothioneins play an important role in the prevention of colonic mucosal inflammation in a mouse model of dextran sulfate sodium-induced colitis. | Role of metallothionein in murine experimental colitis.
Tsuji T, Naito Y, Takagi T, Kugai M, Yoriki H, Horie R, Fukui A, Mizushima K, Hirai Y, Katada K, Kamada K, Uchiyama K, Handa O, Konishi H, Yagi N, Ichikawa H, Yanagisawa R, Suzuki JS, Takano H, Satoh M, Yoshikawa T. | 11/2/2013 |
| Metallothioneins act as negative regulators for IL-27-induced Tr1 cells. | Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.
Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK., Free PMC Article | 07/20/2013 |
| Zn deficiency in utero induces fetal epigenetic alterations of Mt2 gene and these changes are being stored as an epigenetic memory until adulthood. | Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.
Kurita H, Ohsako S, Hashimoto S, Yoshinaga J, Tohyama C. | 05/25/2013 |
| MT1 + 2 effectively alters the amyloid cascade, survival, body weight, and behavior in a complex manner | Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease.
Manso Y, Carrasco J, Comes G, Adlard PA, Bush AI, Hidalgo J., Free PMC Article | 12/29/2012 |
| Down-regulation of MT1 and MT2 after electromagnetic fields in mouse testis might be followed by some consequences that result in infertility. | Down-regulation of metallothionein 1 and 2 after exposure to electromagnetic field in mouse testis.
Ebrahimi-Kalan A, Roudkenar MH, Halabian R, Milan PB, Zarrintan A, Roushandeh AM., Free PMC Article | 09/29/2012 |
| MT-I/II is up-regulated in the liver after brain injury and modulates the amount of zinc that is sequestered to the liver. | Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.
Pankhurst MW, Gell DA, Butler CW, Kirkcaldie MT, West AK, Chung RS., Free PMC Article | 06/30/2012 |
| the absence of MT1 and MT2 has no unfavorable effect on ischemic brain injury | Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia.
Kilic U, Yilmaz B, Ugur M, Yüksel A, Reiter RJ, Hermann DM, Kilic E. | 05/26/2012 |
| Data suggest that metallothionein (MT)-I/II(-/-) mice have altered immune function and provide a new hypothesis that this alteration is partly responsible for the differences observed in MT-I/II(-/-) mice after brain injury relative to wild type mice. | Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT)-I/II null mutant mice.
Pankhurst MW, Bennett W, Kirkcaldie MT, West AK, Chung RS., Free PMC Article | 04/21/2012 |
| Knockdown of metallothionein 2 does not affect atrophy or oxidant activity in skeletal myotubes subject to serum reduction. | Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model.
Hyldahl RD, O'Fallon KS, Schwartz LM, Clarkson PM. | 02/26/2011 |
| Induction of metallothionein-I and -II occurs in the retinitis pigmentosa models studied and correlates with glial activation | Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration.
Wunderlich KA, Leveillard T, Penkowa M, Zrenner E, Perez MT. | 10/23/2010 |