| Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation. | Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation.
Xiong T, Li Y, Yang M, Huo B, Guo X, Liu L, Huang Y, Zhu X, Hu Q, Wei X, Jiang DS, Yi X., Free PMC Article | 10/29/2024 |
| A role of metallothionein-3 in radiation-induced autophagy in glioma cells. | A role of metallothionein-3 in radiation-induced autophagy in glioma cells.
Cho YH, Lee SH, Lee SJ, Kim HN, Koh JY., Free PMC Article | 11/21/2020 |
| MT3 programs the phenotype and metabolic fate of M(IL-4) macrophages. | Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.
Chowdhury D, Alrefai H, Landero Figueroa JA, Candor K, Porollo A, Fecher R, Divanovic S, Deepe GS Jr, Subramanian Vignesh K., Free PMC Article | 08/1/2020 |
| the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization. | Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization.
Lee SJ, Seo BR, Koh JY., Free PMC Article | 07/16/2016 |
| Circadian time and lighting could be involved in the regulation of the expression of melatonin receptors MTNR3 and Rorc. | The expression of MTNR3 and nuclear receptors in murine leucocytes.
Cernysiov V, Bozaite R, Mauricas M, Girkontaite I. | 05/23/2015 |
| Mt3 may act through PDE3a to play a key role in Zinc dyshomeostasis and cell death in streptozotocin-treated islets. | The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice.
Byun HR, Choi JA, Koh JY. | 04/25/2015 |
| Zn released from MT3 may contribute to VEGF induction. | Methallothionein-3 contributes to vascular endothelial growth factor induction in a mouse model of choroidal neovascularization.
Choi JA, Hwang JU, Yoon YH, Koh JY. | 05/24/2014 |
| The entire MT3 peptide shows a high capacity to bind Cu(+) , provided that this occurs in a nonoxidative milieux. This reflects a peculiar property of this MT isoform, which senses different Cu contents in the environment in which it is synthesized. | In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein.
Artells E, Palacios O, Capdevila M, Atrian S. | 05/17/2014 |
| MT-III can help protect against light-induced retinal damage compared to MT-I/II. Some of these effects may be exerted by its antioxidative potency. | Metallothionein-III deficiency exacerbates light-induced retinal degeneration.
Tsuruma K, Shimazaki H, Ohno Y, Inoue Y, Honda A, Imai S, Lee J, Shimazawa M, Satoh M, Hara H. | 01/26/2013 |
| MT-3 is able to alter the Tg2576 phenotype in several aspects such as mortality and behavior in a gender-dependent manner. | Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease.
Manso Y, Carrasco J, Comes G, Meloni G, Adlard PA, Bush AI, Vašák M, Hidalgo J., Free PMC Article | 12/29/2012 |
| ZnMt3 in cultured astrocytes may be a normal component of c-Abl activation in EGF receptor signaling | Role of zinc metallothionein-3 (ZnMt3) in epidermal growth factor (EGF)-induced c-Abl protein activation and actin polymerization in cultured astrocytes.
Lee SJ, Cho KS, Kim HN, Kim HJ, Koh JY., Free PMC Article | 01/21/2012 |
| the level of the leptin receptor in the hypothalamus of metallothionein-3-null mice was significantly reduced | Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice.
Byun HR, Kim DK, Koh JY. | 12/3/2011 |
| Metallothionein-III null mice show attenuation of cadmium-induced severe testicular toxicity, suggesting that lack of MT-III contributes to protection of testis from cadmium. | Attenuation of cadmium-induced testicular injury in metallothionein-III null mice.
Honda A, Komuro H, Shimada A, Hasegawa T, Seko Y, Nagase H, Hozumi I, Inuzuka T, Hara H, Fujiwara Y, Satoh M. | 11/6/2010 |
| results indicate that MT3 may play a key role in normal lysosomal function in cultured astrocytes | Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions.
Lee SJ, Park MH, Kim HJ, Koh JY. | 09/20/2010 |
| findings indicate that abnormalities of psychological behavior were observed in the MT-3 knock-out mice | Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors.
Koumura A, Kakefuda K, Honda A, Ito Y, Tsuruma K, Shimazawa M, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H. | 03/1/2010 |
| These findings indicate that neuronal damage was aggravated by reperfusion injury in the MT-III KO mice compared with the wild-type mice, suggesting that MT-III plays anti-oxidative and neuroprotective roles in transient cerebral ischemia. | Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia.
Koumura A, Hamanaka J, Shimazawa M, Honda A, Tsuruma K, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H. | 01/21/2010 |
| MT-III isoform, which has a limited tissue distribution, especially in the central nervous system, seems to be implicated in tissue repair and/or protection against critical tissue injury | Different patterns in the induction of metallothionein mRNA synthesis among isoforms after acute ethanol administration.
Ono S, Ishizaki Y, Tokuda E, Tabata K, Asami S, Suzuki T. | 01/21/2010 |
| In contrast to MT-I, MT-III mRNA expression was not significantly altered in any of the models examined suggesting that the various MT isoforms may have different roles in these experimental systems, and perhaps also in human AD. | Metallothionein-I and -III expression in animal models of Alzheimer disease.
Carrasco J, Adlard P, Cotman C, Quintana A, Penkowa M, Xu F, Van Nostrand WE, Hidalgo J. | 01/21/2010 |
| engineered protein has neuroinhibitory activity when introduced into metallothionein-1 | Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1.
Romero-Isart N, Jensen LT, Zerbe O, Winge DR, Vasak M. | 01/21/2010 |
| Metallothionein 3 [Mt3]-null mice had increased expression of neurotrophins as well as GAP-43 following cryoinjury. Thus MT-III does not affect the inflammatory response, but it may influence neuronal regeneration during recovery | Role of metallothionein-III following central nervous system damage.
Carrasco J, Penkowa M, Giralt M, Camats J, Molinero A, Campbell IL, Palmiter RD, Hidalgo J. | 01/21/2010 |
| a correct MTs homeostasis is pivotal for brain-endocrine-immune response in order to reach successful ageing. | Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.
Giacconi R, Cipriano C, Muzzioli M, Gasparini N, Orlando F, Mocchegiani E. | 01/21/2010 |