| Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog. | Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog.
Wong CYY, Tsui HN, Wang Y, Yuen KWY., Free PMC Article | 09/25/2024 |
| A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3' processing. | A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3' processing.
Waddell BM, Wu CW., Free PMC Article | 09/13/2024 |
| Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. | Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.
Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM., Free PMC Article | 09/11/2021 |
| Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1. | Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1.
Nguyen DAH, Phillips CM., Free PMC Article | 07/24/2021 |
| Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis. | Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis.
Singh M, Cornes E, Li B, Quarato P, Bourdon L, Dingli F, Loew D, Proccacia S, Cecere G., Free PMC Article | 06/26/2021 |
| most highly expressed genes produce 22G-RNAs through a distinct pathway that presumably involves the Argonaute CSR-1. | Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans.
Reed KJ, Svendsen JM, Brown KC, Montgomery BE, Marks TN, Vijayasarathy T, Parker DM, Nishimura EO, Updike DL, Montgomery TA., Free PMC Article | 03/21/2020 |
| targeting by the CSR-1 Argonaute correlates with reduced piRNA binding density and suppression of piRNA-associated secondary small RNAs. | Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline.
Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC., Free PMC Article | 01/26/2019 |
| CSR1 role in accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans. | The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
Fassnacht C, Tocchini C, Kumari P, Gaidatzis D, Stadler MB, Ciosk R., Free PMC Article | 07/14/2018 |
| Disruption of CSR-1 results in differential dauer-deficient phenotypes that are dependent upon the experienced environmental stress. CSR-1 is required for expression of a subset of G proteins with functions in the detection of pheromone components. | Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans.
Bharadwaj PS, Hall SE., Free PMC Article | 05/20/2017 |
| The CSR-1 pathway helps maintain the directionality of active transcription, thereby propagating the distinction between transcriptionally active and silent genomic regions. | Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.
Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A., Free PMC Article | 06/21/2014 |
| Study shows that the CSR-1 Argonaute functions with ALG-3/4 to positively regulate target genes required for spermiogenesis; these findings are consistent with a model in which ALG-3/4 and CSR-1 and their associated small RNAs provide an epigenetic memory of paternal gene expression, thereby ensuring the transgenerational continuity of a robust spermiogenic program. | Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.
Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC., Free PMC Article | 03/1/2014 |
| It was shown that CSR-1 directly binds to histone mRNA in an ego-1-dependent manner. Increasing the dosage of histone genes rescued the lethality associated with depletion of CSR-1 and EGO-1. | CSR-1 RNAi pathway positively regulates histone expression in C. elegans.
Avgousti DC, Palani S, Sherman Y, Grishok A., Free PMC Article | 01/12/2013 |
| The cde-1 gene, K10D2.3, encodes the TRF-like nucleotidyltransferases CDE-1, study found that CDE-1 is required for the uridylation of CSR-1 bound siRNAs and chromosome segregation. | CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs.
van Wolfswinkel JC, Claycomb JM, Batista PJ, Mello CC, Berezikov E, Ketting RF. | 01/21/2010 |
| Study shows that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicase DRH-3, and the Tudor-domain protein EKL-1 localize to chromosomes and are required for proper chromosome segregation. | The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.
Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D Jr, Mello CC., Free PMC Article | 01/21/2010 |