| Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction. | Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.
Lee M, Won Y, Shin Y, Kim JH, Chun JS. | 10/1/2016 |
| MTF1 mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus. | Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.
van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ., Free PMC Article | 05/14/2016 |
| the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element | Expression and characterization of SUMO-conjugated metal-responsive transcription factor 1: SIM-dependent cross-interaction and distinct DNA binding activity.
Lin CY, Liu YC, Lin MC, Thi Nguyen T, Tam MF, Chein CY, Lin MT, Lin LY. | 09/21/2013 |
| nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1. | Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.
Zhang Y, Andrews GK, Wang L., Free PMC Article | 08/18/2012 |
| MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc. | Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1).
Dubé A, Harrisson JF, Saint-Gelais G, Séguin C., Free PMC Article | 03/10/2012 |
| PTEN associates with MTF-1 in cells in response to oxidative stress and in zinc homeostasis. | PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity.
Lin MC, Liu YC, Tam MF, Lu YJ, Hsieh YT, Lin LY. | 02/18/2012 |
| Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription. | MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.
Lichten LA, Ryu MS, Guo L, Embury J, Cousins RJ., Free PMC Article | 12/3/2011 |
| Data show that disruption of nucleosome structure at the MT-I promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex. | The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter.
Okumura F, Li Y, Itoh N, Nakanishi T, Isobe M, Andrews GK, Kimura T. | 03/5/2011 |
| Zinc and cadmium can activate FPN1 transcription through the MTF-1. | Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.
Troadec MB, Ward DM, Lo E, Kaplan J, De Domenico I., Free PMC Article | 01/15/2011 |
| identify the major determinant for the nuclear import of MTF-1 to be a nonconventional nuclear localization signal in the region spanning zinc fingers 1 to 3. | Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain.
Lindert U, Cramer M, Meuli M, Georgiev O, Schaffner W., Free PMC Article | 01/21/2010 |
| The mechanisms of transactivation of gene expression by mouse metal response element-binding transcription factor 1 (MTF-1) were investigated. | Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1.
Li Y, Kimura T, Huyck RW, Laity JH, Andrews GK., Free PMC Article | 01/21/2010 |
| HIF-1alpha functions as a coactivator of the metallothionein gene transcription by interacting with MTF-1 during hypoxia. | Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha.
Murphy BJ, Kimura T, Sato BG, Shi Y, Andrews GK. | 01/21/2010 |
| Nuclear factor-1 acts synergistically with MTF-1 to activate the mouse metallothionein-1 promoter in response to metal ions | Nuclear factor-1 and metal transcription factor-1 synergistically activate the mouse metallothionein-1 gene in response to metal ions.
LaRochelle O, Labbé S, Harrisson JF, Simard C, Tremblay V, St-Gelais G, Govindan MV, Séguin C. | 01/21/2010 |
| Highly inducible strains having Mtf-1 of proline type are refractory to radiation effects and hence are resistant to lymphoma development. | Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1).
Tamura Y, Maruyama M, Mishima Y, Fujisawa H, Obata M, Kodama Y, Yoshikai Y, Aoyagi Y, Niwa O, Schaffner W, Kominami R. | 01/21/2010 |
| mouse MTF-1 is polymorphic | Putative zinc-sensing zinc fingers of metal-response element-binding transcription factor-1 stabilize a metal-dependent chromatin complex on the endogenous metallothionein-I promoter.
Jiang H, Daniels PJ, Andrews GK. | 01/21/2010 |
| Zinc sensing by MTF-1 in eukaryotic cells involves multiple zinc fingers and occurs over a 100-fold or less range of accessible Zn(II) concentration. | The six zinc fingers of metal-responsive element binding transcription factor-1 form stable and quasi-ordered structures with relatively small differences in zinc affinities.
Potter BM, Feng LS, Parasuram P, Matskevich VA, Wilson JA, Andrews GK, Laity JH. | 01/21/2010 |
| Together, these novel findings define a role for MTF-1 in the regulation of HIF-1 activity. | The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress.
Murphy BJ, Sato BG, Dalton TP, Laderoute KR. | 01/21/2010 |
| MTF1 plays a critical role in embryonic liver formation, heavy metal toxicity, and hematopoiesis. | Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver.
Wang Y, Wimmer U, Lichtlen P, Inderbitzin D, Stieger B, Meier PJ, Hunziker L, Stallmach T, Forrer R, Rülicke T, Georgiev O, Schaffner W. | 01/21/2010 |
| We also show that large thymocytes with higher ROS levels and a proliferation capacity were more numerous in the Mtf-1 susceptible mice than the resistant mice when examined at 7 days after irradiation. | Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after gamma-irradiation.
Maruyama M, Yamamoto T, Kohara Y, Katsuragi Y, Mishima Y, Aoyagi Y, Kominami R. | 01/21/2010 |
| New MTF-1 target genes with metal response elements motifs in the promoter region were identified. | Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione.
Wimmer U, Wang Y, Georgiev O, Schaffner W., Free PMC Article | 01/21/2010 |
| Zinc finger domains 1, 3, and 6 of MTF1, in particular domains 1 and 6, show lower metal ion affinities and remain as the most likely candidates if the Cys2His2 metal ion-binding sites of MTF1 are, indeed, responsible for zinc sensing in vivo. | Metal ion affinities of the zinc finger domains of the metal responsive element-binding transcription factor-1 (MTF1).
Guerrerio AL, Berg JM. | 01/21/2010 |
| Results suggest a mechanism by which physiological concentrations of accessible cellular zinc affect MTF-1 activity. | The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers.
Li Y, Kimura T, Laity JH, Andrews GK., Free PMC Article | 01/21/2010 |
| MTF-1 enhances the ability of the developing tumor mass to evade fibrosis and scarring of the tumor, a critical step in tumor cell proliferation. | Loss of metal transcription factor-1 suppresses tumor growth through enhanced matrix deposition.
Haroon ZA, Amin K, Lichtlen P, Sato B, Huynh NT, Wang Z, Schaffner W, Murphy BJ. | 01/21/2010 |