| Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis. | Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.
Bisikirska B, Labella R, Cuesta-Dominguez A, Luo N, De Angelis J, Mosialou I, Lin CS, Beck D, Lata S, Shyu PT, McMahon DJ, Guo E, Hagen J, Chung WK, Shane E, Cohen A, Kousteni S. | 10/23/2024 |
| The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. | The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC. | 09/18/2021 |
| Changes in melatonin receptor expression in a murine model of glaucoma. | Changes in melatonin receptor expression in a murine model of glaucoma.
Martínez-Águila A, Fonseca B, Pérez de Lara MJ, Miras-Portugal MT, Gómez-Villafuertes R, Carracedo G, Pintor J., Free PMC Article | 07/3/2021 |
| found in The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and endolymphatic sac epithelial cells | Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.
Takumida M, Anniko M. | 03/7/2020 |
| MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations. | MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
Klosen P, Lapmanee S, Schuster C, Guardiola B, Hicks D, Pevet P, Felder-Schmittbuhl MP. | 12/21/2019 |
| study presents the first direct evidence that the MT2 subtype, but not MT1, is a novel endogenous cardiac protective receptor against MI/R injury. Medications specifically targeting MT2 may hold promise in fighting ischemic heart disease. | Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury.
Han D, Wang Y, Chen J, Zhang J, Yu P, Zhang R, Li S, Tao B, Wang Y, Qiu Y, Xu M, Gao E, Cao F. | 12/21/2019 |
| MT1/MT2 receptors activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. | Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J. | 12/21/2019 |
| These results suggested that the melatonin receptors MTNR1A and MTNR1B are essential to repress hCG-induced endoplasmic reticulum stress and cell apoptosis. | Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
Gao Y, Wu X, Zhao S, Zhang Y, Ma H, Yang Z, Yang W, Zhao C, Wang L, Zhang Q., Free PMC Article | 05/18/2019 |
| Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum. | Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.
Benleulmi-Chaachoua A, Hegron A, Le Boulch M, Karamitri A, Wierzbicka M, Wong V, Stagljar I, Delagrange P, Ahmad R, Jockers R., Free PMC Article | 11/10/2018 |
| our data demonstrate that the activation of MT1 signaling at night modulates insulin sensitivity during the day via the regulation of the PI3K transcription and activity | Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.
Owino S, Sánchez-Bretaño A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G., Free PMC Article | 09/1/2018 |
| knockdown of melatonin receptor leads to interference in the normal physiological function of the ovary by enhancing follicular apoptosis, inhibiting proliferation, and influencing hormonal signaling | Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function.
Talpur HS, Worku T, Rehman ZU, Dad R, Bhattarai D, Bano I, Farmanullah, Liang A, He C, Yang L. | 07/28/2018 |
| the present study shows that MT1 receptor deficiency alters the temporal feeding pattern but not the amount of food ingested, and melatonin signaling mediated through the MT1 receptor stimulates Pro-Opiomelanocortin expression in both the ARC and PD of mice. | Melatonin Receptor 1 Deficiency Affects Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice.
Fischer C, Mueller T, Pfeffer M, Wicht H, von Gall C, Korf HW. | 03/24/2018 |
| Taken together, these data suggest that melatonin-MT1 receptor complexes represent a potential target for the treatment of glioma. | The melatonin-MT1 receptor axis modulates tumor growth in PTEN-mutated gliomas.
Ma H, Wang Z, Hu L, Zhang S, Zhao C, Yang H, Wang H, Fang Z, Wu L, Chen X. | 03/17/2018 |
| Ecto-5'-nucleotidase mRNA levels were found to be diminished in both MT1 and MT1/2 knockout mice. | Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon.
Homola M, Pfeffer M, Robson SC, Fischer C, Zimmermann H, Korf HW. | 05/6/2017 |
| The removal of MT1R or MT2R in mice abolished the daily rhythm in blood glucose levels, but produced small effects on the rhythmic expression patterns of clock genes within skeletal muscle, liver, and adipose tissue. | Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks.
Owino S, Contreras-Alcantara S, Baba K, Tosini G., Free PMC Article | 07/16/2016 |
| We have shown that melatonin receptors are expressed in embryonic salivary glands, specifically during salivary gland branching morphogenesis. Melatonin inhibits branching morphogenesis independent of both apoptosis and cell proliferation. | Melatonin inhibits embryonic salivary gland branching morphogenesis by regulating both epithelial cell adhesion and morphology.
Obana-Koshino A, Ono H, Miura J, Sakai M, Uchida H, Nakamura W, Nohara K, Maruyama Y, Hattori A, Sakai T., Free PMC Article | 01/16/2016 |
| MT1 melatonin receptors are involved in neural pathways modulating diurnal rhythms of spontaneous behavior in the homecage as well as pathways regulating depressive and anxiolytic-like behaviors. | Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice.
Adamah-Biassi EB, Hudson RL, Dubocovich ML., Free PMC Article | 11/21/2015 |
| These data demonstrate that melatonin MT1 receptor knockout mice recapitulate several behavioral and neurobiological circadian changes. | Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.
Comai S, Ochoa-Sanchez R, Dominguez-Lopez S, Bambico FR, Gobbi G., Free PMC Article | 10/31/2015 |
| The effect of miR-29b on endothelial permeability and apoptosis is mediated through the down-regulation of melatonin receptor 1. | MicroRNA-29b promotes high-fat diet-stimulated endothelial permeability and apoptosis in apoE knock-out mice by down-regulating MT1 expression.
Zhu HQ, li Q, Dong LY, Zhou Q, Wang H, Wang Y. | 07/25/2015 |
| there is an an increased proinflammatory status of mice deficient in both membrane-bound melatonin receptors reflected by altered activation of MAPK cascades and transcriptional activation of proinflammatory mediators | Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.
Kleber A, Altmeyer S, Wolf B, Wolf A, Volk T, Fink T, Kubulus D. | 07/25/2015 |
| This study demonistrated that METH-induced CPP is dependent on time of day and the presence of the MT1 receptor, suggesting a role for melatonin in METH-induced reward. | Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice.
Clough SJ, Hutchinson AJ, Hudson RL, Dubocovich ML., Free PMC Article | 01/24/2015 |
| Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. | Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
Baba K, Benleulmi-Chaachoua A, Journé AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G., Free PMC Article | 05/3/2014 |
| These data suggest that melatonin, by acting on MT1 receptors, affects NeuroD expression in the gastrointestinal tract and thus might contribute to circadian regulation in metabolic functions. | Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice.
Shalabi A, Fischer C, Korf HW, von Gall C. | 03/22/2014 |
| MT1R signaling and BMP-4 actions are mutually augmented, leading to fine-tuning of ACTH production by corticotrope cells. | Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells.
Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H. | 02/8/2014 |
| Deletion of the MT1 and MT2 melatonin receptors decreases the development and expression of methamphetamine-induced locomotor sensitization during the light period. | Genetic deletion of MT(1) and MT(2) melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice.
Hutchinson AJ, Hudson RL, Dubocovich ML., Free PMC Article | 03/23/2013 |