| A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging. | A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.
Ancel S, Michaud J, Sizzano F, Tauzin L, Oliveira M, Migliavacca E, Schüler SC, Raja S, Dammone G, Karaz S, Sánchez-García JL, Metairon S, Jacot G, Bentzinger CF, Feige JN, Stuelsatz P., Free PMC Article | 08/6/2024 |
| Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice. | Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Wang S, Cao Q, Cui X, Jing J, Li F, Shi H, Xue B, Shi H., Free PMC Article | 10/30/2021 |
| PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism. | PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
Risha MA, Siengdee P, Dannenberger D, Wimmers K, Ponsuksili S., Free PMC Article | 07/24/2021 |
| MLL1 facilitates proliferation of myoblasts and Pax7-positive satellite cells by epigenetically regulating Myf5. | MLL1 promotes myogenesis by epigenetically regulating Myf5.
Cai S, Zhu Q, Guo C, Yuan R, Zhang X, Nie Y, Chen L, Fang Y, Chen K, Zhang J, Mo D, Chen Y., Free PMC Article | 03/7/2020 |
| The induction phase of primary Myf5+ brown adipogenesis. | STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis.
Cantwell MT, Farrar JS, Lownik JC, Meier JA, Hyun M, Raje V, Waters MR, Celi FS, Conrad DH, Harris TE, Larner AC., Free PMC Article | 11/16/2019 |
| Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. | The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
Chang NC, Sincennes MC, Chevalier FP, Brun CE, Lacaria M, Segalés J, Muñoz-Cánoves P, Ming H, Rudnicki MA., Free PMC Article | 09/7/2019 |
| An absolute requirement for either MyoD or Myf5 in muscle regeneration. | Loss of MyoD and Myf5 in Skeletal Muscle Stem Cells Results in Altered Myogenic Programming and Failed Regeneration.
Yamamoto M, Legendre NP, Biswas AA, Lawton A, Yamamoto S, Tajbakhsh S, Kardon G, Goldhamer DJ., Free PMC Article | 02/16/2019 |
| Novel RNA-binding activity of MYF5 enhances Ccnd1 mRNA translation during myogenesis. | Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.
Panda AC, Abdelmohsen K, Martindale JL, Di Germanio C, Yang X, Grammatikakis I, Noh JH, Zhang Y, Lehrmann E, Dudekula DB, De S, Becker KG, White EJ, Wilson GM, de Cabo R, Gorospe M., Free PMC Article | 08/13/2016 |
| Transcription of the skeletal muscle program is achieved by the expression of MyoD, which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites | Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation.
Conerly ML, Yao Z, Zhong JW, Groudine M, Tapscott SJ., Free PMC Article | 07/30/2016 |
| The Myf5- and Myogenin-deficient mice showed a partial or complete, respectively, loss of TMC in an otherwise regularly structured thymus. | Myf5 and Myogenin in the development of thymic myoid cells - Implications for a murine in vivo model of myasthenia gravis.
Hu B, Simon-Keller K, Küffer S, Ströbel P, Braun T, Marx A, Porubsky S. | 07/2/2016 |
| Elimination of Myf5(Cre)-DTA cells on a Myod null background did not result in the total absence of skeletal muscles | Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations.
Comai G, Sambasivan R, Gopalakrishnan S, Tajbakhsh S. | 02/28/2015 |
| A muscle-specific regulatory element of p57(kip2) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch targets Hes1/Hey1 in progenitor cells, is identified. | Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest.
Zalc A, Hayashi S, Auradé F, Bröhl D, Chang T, Mademtzoglou D, Mourikis P, Yao Z, Cao Y, Birchmeier C, Relaix F. | 09/6/2014 |
| lineage tracing based on multiple reporter lines has demonstrated that regardless of common ancestral expression of Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages | Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin.
Stuelsatz P, Shearer A, Yablonka-Reuveni Z., Free PMC Article | 03/8/2014 |
| The results demonstrate the heterogeneity and functional differences of the Myf5- and non-Myf5-lineage cells in the white adipose tissue. | Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues.
Shan T, Liang X, Bi P, Zhang P, Liu W, Kuang S., Free PMC Article | 03/1/2014 |
| Adult satellite cells derive from progenitors that first express the myogenic determination gene Myf5 during fetal stages of myogenesis. | Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells.
Biressi S, Bjornson CR, Carlig PM, Nishijo K, Keller C, Rando TA., Free PMC Article | 08/31/2013 |
| Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer | Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer.
Daubas P, Buckingham ME. | 05/18/2013 |
| The observations provide a mechanism linking Myf5 levels to muscle stem cell heterogeneity and fate by exposing two distinct and opposing phenotypes associated with Myf5 haploinsufficiency. | Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells.
Gayraud-Morel B, Chrétien F, Jory A, Sambasivan R, Negroni E, Flamant P, Soubigou G, Coppée JY, Di Santo J, Cumano A, Mouly V, Tajbakhsh S. | 02/9/2013 |
| Mesenchymal precursors expressing Myf5--which are thought to give rise only to brown adipocytes and skeletal muscle--also give rise to a subset of white adipocytes. | PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.
Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA., Free PMC Article | 01/12/2013 |
| Myf5 mRNA, together with microRNA-31, which regulates its translation. | Muscle satellite cells are primed for myogenesis but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules.
Crist CG, Montarras D, Buckingham M. | 11/17/2012 |
| Data show that correct levels of expression of Myf5 and MyoD during mouse craniofacial development result from activation by musculin and TCF21 through direct binding to specific enhancers. | Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development.
Moncaut N, Cross JW, Siligan C, Keith A, Taylor K, Rigby PW, Carvajal JJ., Free PMC Article | 05/12/2012 |
| follistatin stimulated myoblasts to express MyoD, Myf5, and myogenin, which are myogenic transcription factors that promote myogenic differentiation | Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis.
Zhu J, Li Y, Lu A, Gharaibeh B, Ma J, Kobayashi T, Quintero AJ, Huard J., Free PMC Article | 04/14/2012 |
| Upregulation of myf5 mRNA and a decrease of myoD protein level during leucine starvation. | Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation.
Averous J, Gabillard JC, Seiliez I, Dardevet D. | 03/17/2012 |
| Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. | Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.
Ribas R, Moncaut N, Siligan C, Taylor K, Cross JW, Rigby PW, Carvajal JJ., Free PMC Article | 09/10/2011 |
| Myf5-dependent myogenesis is insensitive to genotoxins | An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis.
Innocenzi A, Latella L, Messina G, Simonatto M, Marullo F, Berghella L, Poizat C, Shu CW, Wang JY, Puri PL, Cossu G., Free PMC Article | 05/28/2011 |
| Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation | A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.
Pan H, Gustafsson MK, Aruga J, Tiedken JJ, Chen JC, Emerson CP Jr., Free PMC Article | 04/9/2011 |