| Intraocular pressure across the lifespan of Tg-MYOC[Y437H] mice. | Intraocular pressure across the lifespan of Tg-MYOC(Y437H) mice.
Zhang X, Xi G, Feng P, Li C, Kuehn MH, Zhu W. | 03/28/2024 |
| MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer. | MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Judge SM, Deyhle MR, Neyroud D, Nosacka RL, D'Lugos AC, Cameron ME, Vohra RS, Smuder AJ, Roberts BM, Callaway CS, Underwood PW, Chrzanowski SM, Batra A, Murphy ME, Heaven JD, Walter GA, Trevino JG, Judge AR., Free PMC Article | 10/24/2020 |
| Phenotypic differences observed in mouse and human studies of mutant myocilin could be a function of aggregation kinetics rates, which would alter the lifetime of putatively toxic protofibrillar intermediates. | Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice.
Patterson-Orazem AC, Hill SE, Wang Y, Dominic IM, Hall CK, Lieberman RL., Free PMC Article | 01/18/2020 |
| For this study, we utilized a transgenic mouse expressing human mutant MYOC Y437H protein and we examined its skeletal (gastrocnemius) muscle phenotype. Electron micrographs showed that sarcomeres in the skeletal muscle of mutant CMV-MYOC-Y437H mice had multiple M-bands. | Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle.
Lynch JM, Dolman AJ, Guo C, Dolan K, Xiang C, Reda S, Li B, Prasanna G., Free PMC Article | 04/27/2019 |
| chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates. | Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Lynch JM, Li B, Katoli P, Xiang C, Leehy B, Rangaswamy N, Saenz-Vash V, Wang YK, Lei H, Nicholson TB, Meredith E, Rice DS, Prasanna G, Chen A., Free PMC Article | 04/13/2019 |
| mutant myocilin induces abnormal ECM accumulation in the ER of TM cells, which may be responsible for reduced outflow facility and IOP elevation in myocilin-associated glaucoma. | Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.
Kasetti RB, Phan TN, Millar JC, Zode GS., Free PMC Article | 05/27/2017 |
| Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma | Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.
Joe MK, Nakaya N, Abu-Asab M, Tomarev SI., Free PMC Article | 02/6/2016 |
| myocilin promotes cell proliferation and resistance to apoptosis via the ERK1/2 MAPK signaling pathway. | Myocilin regulates cell proliferation and survival.
Joe MK, Kwon HS, Cojocaru R, Tomarev SI., Free PMC Article | 05/31/2014 |
| Myocilin binds to ErbB2/ErbB3, activates these receptors, and affects the downstream PI3K-AKT signaling pathway | Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.
Kwon HS, Johnson TV, Joe MK, Abu-Asab M, Zhang J, Chan CC, Tomarev SI., Free PMC Article | 12/21/2013 |
| Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38, Erk1/2, and JNK MAP kinase signaling pathways | Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling.
Kwon HS, Johnson TV, Tomarev SI., Free PMC Article | 08/31/2013 |
| We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin associated protein complex. | Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
Joe MK, Kee C, Tomarev SI., Free PMC Article | 06/23/2012 |
| Results suggest that expression of mutated myocilins may have a sensitization effect to oxidative stress, which can lead to a severe open-angle glaucoma phenotype in combination with oxidative stress. | Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis.
Joe MK, Tomarev SI., Free PMC Article | 10/23/2010 |
| The TIGR is implicated in resistance to oxidative stress. Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity. | A novel giant peroxisomal superoxide dismutase motif-containing protein.
Toutzaris D, Lewerenz J, Albrecht P, Jensen LT, Letz J, Geerts A, Golz S, Methner A. | 07/5/2010 |
| myocilin induced the formation of stress fibers; myocilin modulates Wnt signaling by interacting with components of signaling pathwaysin the eye | Myocilin is a modulator of Wnt signaling.
Kwon HS, Lee HS, Ji Y, Rubin JS, Tomarev SI., Free PMC Article | 01/21/2010 |
| Expression of equivalent levels of mutated human or mouse myocilin in the eyes of transgenic mice produce comparable pathologic changes that are similar to those observed in patients with glaucoma. | Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.
Zhou Y, Grinchuk O, Tomarev SI., Free PMC Article | 01/21/2010 |
| TIGR is a newly identified component of the CNS glial scar that is likely to contribute to neuronal regenerative failure characteristic of the mammalian CNS. | TIGR is upregulated in the chronic glial scar in response to central nervous system injury and inhibits neurite outgrowth.
Jurynec MJ, Riley CP, Gupta DK, Nguyen TD, McKeon RJ, Buck CR. | 01/21/2010 |
| Tg animals expressed Myoc in tissues of the irido-corneal angle and the sclera. Expression of mutated Myoc induced the accumulation of Myoc in cell cytoplasm and prevented its secretion into the extracellular space. | Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.
Senatorov V, Malyukova I, Fariss R, Wawrousek EF, Swaminathan S, Sharan SK, Tomarev S., Free PMC Article | 01/21/2010 |
| Results do not support a causative role for increased MYOC levels or the MYOC gene in steroid-induced glaucoma. | Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma.
Gould DB, Miceli-Libby L, Savinova OV, Torrado M, Tomarev SI, Smith RS, John SW., Free PMC Article | 01/21/2010 |
| Results show that myocilin and gamma-synuclein interact and as a result, myocilin's properties are changed. | Interaction of myocilin with gamma-synuclein affects its secretion and aggregation.
Surgucheva I, Park BC, Yue BY, Tomarev S, Surguchov A. | 01/21/2010 |
| These data suggest that production, apparent misfolding, and nonsecretion of mutant MYOC are not, by themselves, sufficient to cause glaucoma in vivo. | Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
Gould DB, Reedy M, Wilson LA, Smith RS, Johnson RL, John SW., Free PMC Article | 01/21/2010 |